Ammonium 1-pyrrolidinedithiocarbamate
- Product Name
- Ammonium 1-pyrrolidinedithiocarbamate
- CAS No.
- 5108-96-3
- Chemical Name
- Ammonium 1-pyrrolidinedithiocarbamate
- Synonyms
- APDTC;APDC;AMMONIUM PYRROLIDINEDITHIOCARBAMATE;PYRROLIDINEDITHIOCARBAMATE;APCD;PYRROLIDINEDITHIOCARBAMATE AMMONIUM;AMMONIUM 1-PYRROLIDINECARBODITHIOATE;ammonium pyrrolidine-1-carbodithioate;PDTC, NH4;APDC, PDTC
- CBNumber
- CB8216948
- Molecular Formula
- C5H9NS2.H3N
- Formula Weight
- 164.3
- MOL File
- 5108-96-3.mol
Ammonium 1-pyrrolidinedithiocarbamate Property
- Melting point:
- 153-155 °C(lit.)
- Density
- 1.117 (estimate)
- refractive index
- 1.5300 (estimate)
- storage temp.
- Store at +2°C to +8°C.
- solubility
- 190g/l
- form
- Powder/Solid
- color
- White to off-white
- PH
- 6-7 (50g/l, H2O, 20℃)
- Water Solubility
- 50 g/L (20 ºC)
- Sensitive
- Hygroscopic
- BRN
- 3730472
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 5108-96-3(CAS DataBase Reference)
- EPA Substance Registry System
- 1-Pyrrolidinecarbodithioic acid, ammonium salt (5108-96-3)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- F
- 3
- TSCA
- Yes
- HS Code
- 29339990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 09935
- Product name
- Ammonium pyrrolidinedithiocarbamate
- Purity
- purum p.a., ≥98.0% (NT)
- Packaging
- 25g
- Price
- $72.8
- Updated
- 2024/03/01
- Product number
- 09935
- Product name
- Ammonium pyrrolidinedithiocarbamate
- Purity
- purum p.a., ≥98.0% (NT)
- Packaging
- 1kg
- Price
- $1360
- Updated
- 2024/03/01
- Product number
- 8.21100
- Product name
- Pyrrolidine-1-dithiocarboxylic acid ammonium salt
- Purity
- for synthesis
- Packaging
- 25G
- Price
- $53.3
- Updated
- 2023/06/20
- Product number
- 8.21100
- Product name
- Pyrrolidine-1-dithiocarboxylic acid ammonium salt
- Purity
- for synthesis
- Packaging
- 100G
- Price
- $194
- Updated
- 2023/06/20
- Product number
- 1.07495
- Product name
- Pyrrolidine-1-dithiocarboxylic acid ammonium salt
- Purity
- GR for analysis
- Packaging
- 10g
- Price
- $77.5
- Updated
- 2022/05/15
Ammonium 1-pyrrolidinedithiocarbamate Chemical Properties,Usage,Production
Description
Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-κB activation in vitro (100 μM). At 300 μM, it prevents TNF-α gene expression and protein production in human monocytes after LPS application. In vascular smooth muscle cells, PDTC (10 μM) arrests the cell cycle at the G1 phase with upregulation of p21Cip1 through the p38 MAPK pathway. PDTC (100 μM) also has antioxidant properties.
Chemical Properties
pale yellow crystalline solid
Uses
Ammonium pyrrolidinedithiocarbamate has been used:
- to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
- to reduce neutrophil activity in rats
- to prevent Ca2+ influx in adriamycin (ADR)-treated podocytes
to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells
Uses
1-Pyrrolidinecarbodithioic Acid induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. It also prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA;
General Description
Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells.
Biochem/physiol Actions
Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.
Purification Methods
Purify the salt by recrystallising twice by dissolving in MeOH and adding Et2O. It has also been purified by recrystallisation from EtOH. It is used for the precipitation of As, Bi, Cd, Co, Cu, Fe, Mn, Ni, Pb, Sb, Su, V and Zn from acidic solutions [Kinrade & van Loon Anal Chem 46 1894 1974]. The ethyl ester has b 87-89o/0.01mm. [Synthesis and Polarography: Kitagawa & Taku Bull Chem Soc Jpn 64 2151 1973, Malissa & Sch.ffmann Mikrochim Acta 187 1955, Beilstein 20 III/IV 195, 20/1 V 331.]
Ammonium 1-pyrrolidinedithiocarbamate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ammonium 1-pyrrolidinedithiocarbamate manufacturers
- Product
- Ammonium 1-pyrrolidinedithiocarbamate 5108-96-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-04-15
- Product
- Ammonium 1-pyrrolidinedithiocarbamate 5108-96-3
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2024-04-07
- Product
- Ammonium 1-pyrrolidinedithiocarbamate 5108-96-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-10-13