ChemicalBook > CAS DataBase List > Ammonium 1-pyrrolidinedithiocarbamate

Ammonium 1-pyrrolidinedithiocarbamate

Product Name
Ammonium 1-pyrrolidinedithiocarbamate
CAS No.
5108-96-3
Chemical Name
Ammonium 1-pyrrolidinedithiocarbamate
Synonyms
APDTC;APDC;AMMONIUM PYRROLIDINEDITHIOCARBAMATE;PYRROLIDINEDITHIOCARBAMATE;APCD;PYRROLIDINEDITHIOCARBAMATE AMMONIUM;AMMONIUM 1-PYRROLIDINECARBODITHIOATE;ammonium pyrrolidine-1-carbodithioate;PDTC, NH4;APDC, PDTC
CBNumber
CB8216948
Molecular Formula
C5H9NS2.H3N
Formula Weight
164.3
MOL File
5108-96-3.mol
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Ammonium 1-pyrrolidinedithiocarbamate Property

Melting point:
153-155 °C(lit.)
Density 
1.117 (estimate)
refractive index 
1.5300 (estimate)
storage temp. 
Store at +2°C to +8°C.
solubility 
190g/l
form 
Powder/Solid
color 
White to off-white
PH
6-7 (50g/l, H2O, 20℃)
Water Solubility 
50 g/L (20 ºC)
Sensitive 
Hygroscopic
BRN 
3730472
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
5108-96-3(CAS DataBase Reference)
EPA Substance Registry System
1-Pyrrolidinecarbodithioic acid, ammonium salt (5108-96-3)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-37/39
WGK Germany 
3
F 
3
TSCA 
Yes
HS Code 
29339990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
09935
Product name
Ammonium pyrrolidinedithiocarbamate
Purity
purum p.a., ≥98.0% (NT)
Packaging
25g
Price
$72.8
Updated
2024/03/01
Sigma-Aldrich
Product number
09935
Product name
Ammonium pyrrolidinedithiocarbamate
Purity
purum p.a., ≥98.0% (NT)
Packaging
1kg
Price
$1360
Updated
2024/03/01
Sigma-Aldrich
Product number
8.21100
Product name
Pyrrolidine-1-dithiocarboxylic acid ammonium salt
Purity
for synthesis
Packaging
25G
Price
$53.3
Updated
2023/06/20
Sigma-Aldrich
Product number
8.21100
Product name
Pyrrolidine-1-dithiocarboxylic acid ammonium salt
Purity
for synthesis
Packaging
100G
Price
$194
Updated
2023/06/20
Sigma-Aldrich
Product number
1.07495
Product name
Pyrrolidine-1-dithiocarboxylic acid ammonium salt
Purity
GR for analysis
Packaging
10g
Price
$77.5
Updated
2022/05/15
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Ammonium 1-pyrrolidinedithiocarbamate Chemical Properties,Usage,Production

Description

Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-κB activation in vitro (100 μM). At 300 μM, it prevents TNF-α gene expression and protein production in human monocytes after LPS application. In vascular smooth muscle cells, PDTC (10 μM) arrests the cell cycle at the G1 phase with upregulation of p21Cip1 through the p38 MAPK pathway. PDTC (100 μM) also has antioxidant properties.

Chemical Properties

pale yellow crystalline solid

Uses

Ammonium pyrrolidinedithiocarbamate has been used:

  • to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
  • to reduce neutrophil activity in rats
  • to prevent Ca2+ influx in adriamycin (ADR)-treated podocytes

to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells

Uses

1-Pyrrolidinecarbodithioic Acid induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. It also prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA;

General Description

Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells.

Biochem/physiol Actions

Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.

Purification Methods

Purify the salt by recrystallising twice by dissolving in MeOH and adding Et2O. It has also been purified by recrystallisation from EtOH. It is used for the precipitation of As, Bi, Cd, Co, Cu, Fe, Mn, Ni, Pb, Sb, Su, V and Zn from acidic solutions [Kinrade & van Loon Anal Chem 46 1894 1974]. The ethyl ester has b 87-89o/0.01mm. [Synthesis and Polarography: Kitagawa & Taku Bull Chem Soc Jpn 64 2151 1973, Malissa & Sch.ffmann Mikrochim Acta 187 1955, Beilstein 20 III/IV 195, 20/1 V 331.]

Ammonium 1-pyrrolidinedithiocarbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ammonium 1-pyrrolidinedithiocarbamate Suppliers

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View Lastest Price from Ammonium 1-pyrrolidinedithiocarbamate manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Ammonium 1-pyrrolidinedithiocarbamate 5108-96-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-04-15
airuikechemical co., ltd.
Product
Ammonium 1-pyrrolidinedithiocarbamate 5108-96-3
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
20 tons
Release date
2024-04-07
Hebei Mojin Biotechnology Co., Ltd
Product
Ammonium 1-pyrrolidinedithiocarbamate 5108-96-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-13

5108-96-3, Ammonium 1-pyrrolidinedithiocarbamateRelated Search:

Ammonium acetate Ammonium hydroxide Ammonium formate Phenyl chlorothionocarbonate N-Methyl-2-pyrrolidone Ammonium chloride Ammonium sulfate Thiobenzoic acid Polyvinylpyrrolidone 5-Pyrazolecarboxylic acid Ammonium nitrate AMMONIUM Ammonium dithiocarbamate AMMONIUM CARBAMATE Ammonium 1-pyrrolidinedithiocarbamate (2,6-DICHLORO-4-PYRIDYL)METHYL PYRROLIDINE-1-CARBODITHIOATE 2-OXO-2-(3-OXOTETRAHYDRO-1H-PYRAZOL-1-YL)ETHYL 1-PYRROLIDINECARBODITHIOATE (3-CHLORO-5-(TRIFLUOROMETHYL)(2-PYRIDYLTHIO))PYRROLIDINYLMETHANE-1-THIONE

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