BM 212
- Product Name
- BM 212
- CAS No.
- 146204-42-4
- Chemical Name
- BM 212
- Synonyms
- BM 212;BM 212;BM-212;1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine;BM-212,Inhibitor,Mycobacterium,BM 212,BM212,MmpL3,Bacterial,inhibit,tuberculosis;Piperazine, 1-[[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl]-4-methyl-
- CBNumber
- CB61304163
- Molecular Formula
- C23H25Cl2N3
- Formula Weight
- 414.37
- MOL File
- 146204-42-4.mol
BM 212 Property
- Boiling point:
- 528.3±50.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:0.75(Max Conc. mg/mL);1.81(Max Conc. mM)
Ethanol:3.03(Max Conc. mg/mL);7.31(Max Conc. mM) - form
- A crystalline solid
- pka
- 7.60±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 22986
- Product name
- BM212
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 22986
- Product name
- BM212
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 22986
- Product name
- BM212
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $261
- Updated
- 2024/03/01
- Product number
- 3177CC
- Product name
- Piperazine,1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methyl-
- Packaging
- 10mg
- Price
- $387
- Updated
- 2021/12/16
- Product number
- CS-5953
- Product name
- BM212
- Purity
- 99.87%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
BM 212 Chemical Properties,Usage,Production
Uses
BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 μM[1][2].
References
[1] Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. DOI:10.1128/AAC.42.11.3035
[2] Poce G et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2) DOI:10.1371/journal.pone.0056980
[3] Albertus Viljoen, et al. Fast chemical force microscopy demonstrates that glycopeptidolipids define nanodomains of varying hydrophobicity on mycobacteria. Nanoscale Horiz. 2020 Jun 1;5(6):944-953. DOI:10.1039/c9nh00736a
[4] Delia Deidda, et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. DOI:10.1128/AAC.42.11.3035
BM 212 Preparation Products And Raw materials
Raw materials
Preparation Products
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