ChemicalBook > CAS DataBase List > 2-Methyl-5-nitrobenzenesulfonamide

2-Methyl-5-nitrobenzenesulfonamide

Product Name
2-Methyl-5-nitrobenzenesulfonamide
CAS No.
6269-91-6
Chemical Name
2-Methyl-5-nitrobenzenesulfonamide
Synonyms
Pazopanib Impurity 18;BUTTPARK 52\04-61;IFLAB-BB F1084-0158;Pazopanil impurity 10;4-Nitro-2-toluenesulfonamide;4-nitrotoluene-2-sulfonamide;2-Methyl-5-nitrobenzenesulfomide;2-Methyl-5-nitrosulfonylbenzamide;2-METHYL-5-NITROBENZENESULFONAMIDE;2-METHYL-5-NITROBENZENESULPHONAMIDE
CBNumber
CB6130691
Molecular Formula
C7H8N2O4S
Formula Weight
216.21
MOL File
6269-91-6.mol
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2-Methyl-5-nitrobenzenesulfonamide Property

Melting point:
197-199
Boiling point:
431.4±55.0 °C(Predicted)
Density 
1.475±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Sparingly), Methanol (Slightly)
form 
Solid
pka
9.56±0.60(Predicted)
color 
Yellow to Dark Yellow
CAS DataBase Reference
6269-91-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2935909099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M321190
Product name
2-Methyl-5-nitrobenzenesulfonamide
Packaging
1g
Price
$55
Updated
2021/12/16
SynQuest Laboratories
Product number
8769-1-X5
Product name
2-Methyl-5-nitrobenzenesulfonamide
Packaging
25g
Price
$48
Updated
2021/12/16
AK Scientific
Product number
J11652
Product name
PazopanibImpurity4
Packaging
100mg
Price
$49
Updated
2021/12/16
SynQuest Laboratories
Product number
8769-1-X5
Product name
2-Methyl-5-nitrobenzenesulfonamide
Packaging
10g
Price
$20
Updated
2021/12/16
SynQuest Laboratories
Product number
8769-1-X5
Product name
2-Methyl-5-nitrobenzenesulfonamide
Packaging
100g
Price
$127
Updated
2021/12/16
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2-Methyl-5-nitrobenzenesulfonamide Chemical Properties,Usage,Production

Uses

2-Methyl-5-nitrobenzenesulfonamide is a chemical reagent in the synthesis of good inhibitors of cancer-related carbonic anhydrase. Also used in the synthesis of novel deacetylase inhibitors used in anti-tumor therapy.

Synthesis

121-02-8

6269-91-6

Step B: 2-methyl-5-nitrobenzenesulfonyl chloride (10.0 g, 43.7 mmol) was dissolved in ether (300 mL) under nitrogen protection and cooled to 0 °C. Ammonia (40 mL) was added slowly and the reaction mixture was stirred at 0 °C for about 42 hours. After the reaction was complete, the mixture was filtered and diluted with dichloromethane (600 mL). The organic layer was separated and dried with anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure to give 2-methyl-5-nitrobenzenesulfonamide (9.2 g, 100% yield).1H NMR (DMSO-d6) δ: 8.60 (d, J = 2.4Hz, 1H), 8.34 (dd, J = 8.0,2.4Hz, 1H), 7.77 (br s, 2H), 7.70 (d, J = 8.4Hz, 1H), 7.70 (d, J = 8.4Hz, 1H). 2.71 (s, 3H).

structure and hydrogen bonding

In the 2-Methyl-5-nitrobenzenesulfonamide, C7H8N2O4S, the nitro group is twisted by 9.61 (2)° relative to the benzene ring. In the crystal, mol-ecules are linked by N—H…O and N—H…(O, O) hydrogen bonds between the amino and sulfonyl groups, forming layers parallel to (001)[1].

References

[1] Muhammad Zia-Ur-Rehman. “2-Methyl-5-nitro-benzene-sulfonamide.” Acta crystallographica. Section E, Structure reports online 66 Pt 1 (2009): o136.

2-Methyl-5-nitrobenzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Methyl-5-nitrobenzenesulfonamide manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Methyl-5-nitrobenzenesulfonamide 6269-91-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-03-28
Career Henan Chemical Co
Product
2-Methyl-5-nitrobenzenesulfonamide 6269-91-6
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-01-08

6269-91-6, 2-Methyl-5-nitrobenzenesulfonamideRelated Search:

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Pazopanib Related Compound 2 Pazopanib Impurity 9 1,3-DiMethyl-6-aMino-1H-indazole 2,3-dimethyl-2H-indazol-6-amine hydrochloride 3-Methyl-6-nitro-2H-indazole Pazopanib Related Compound 3 Pazopanib Impurity 2 3-AMINO-4-METHYLBENZENESULFONAMIDE Pazopanib Impurity 3 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE 1,3-Dimethyl-6-nitro-1H-indazole Pazopanib Pazopanib Impurity 8 Pazopanib Impurity 10 Pazopanib Impurity 4 Pazopanib Impurity 9

  • IFLAB-BB F1084-0158
  • BUTTPARK 52\04-61
  • 2-METHYL-5-NITROBENZENESULPHONAMIDE
  • 2-METHYL-5-NITROBENZENESULFONAMIDE
  • 4-Nitro-2-toluenesulfonamide
  • BENZENESULFONAMIDE,2-METHYL-5-NITRO-
  • 2-methyl-5-nitrobenzene-1-sulfonamide
  • 2-Methyl-5-nitro-1-benzenesulfonamide
  • 4-Nitro-2-sulphamoyltoluene, 3-(Aminosulphonyl)-4-methylnitrobenzene
  • 2-Methyl-5-nitrobenzenesulfonaMide, 97+%
  • Pazopanib Impurity 18
  • 2-Methyl-5-nitrobenzenesulfonamide ISO 9001：2015 REACH
  • 4-nitrotoluene-2-sulfonamide
  • Pazopanil impurity 10
  • 2-Methyl-5-nitrobenzenesulfomide
  • 2-Methyl-5-nitrosulfonylbenzamide
  • 6269-91-6
  • Benzene derivates
  • bc0001