inogatran

Product Name: inogatran
CAS No.: 155415-08-0
Chemical Name: inogatran
Synonyms: H-314-27;inogatran;Inogatran (H-314-27);Glycine, N-[(1R)-2-[(2S)-2-[[[3-[(aminoiminomethyl)amino]propyl]amino]carbonyl]-1-piperidinyl]-1-(cyclohexylmethyl)-2-oxoethyl]-
CBNumber: CB61309557
Molecular Formula: C21H38N6O4
Formula Weight: 438.56
MOL File: 155415-08-0.mol

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inogatran Property

Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 2.16±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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inogatran Chemical Properties,Usage,Production

Uses

Inogatran (H-314-27) is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of arterial and venous thrombotic diseases.

in vivo

Inogatran (H-314-27; 0.075, 0.25, 0.75 mg/kg, i.v.) results in dose-dependent increases in activated partial thromboplastin time (aPTT), thrombin time (TT), and prothrombin time (PT) in a canine electrolytic injury model of venous thrombosis^[1].
Inogatran dose-dependently inhibits thrombus formation, which is measured as an increase in time to occlusion (TTO) and a decrease in thrombus weight. Inogatran also improves vena caval blood flow and reduces the overall incidence of thrombotic occlusion in a rat model^[2].

References

[1] Ignasiak DP, et al. Effects of Intravenous Enoxaparin and Intravenous Inogatran in an Electrolytic Injury Model of Venous Thrombosis in the Dog. J Thromb Thrombolysis. 1998 Nov;6(3):199-206. DOI:10.1023/A:1008806312396
[2] Chi L, et al. Antithrombotic effect of LB-30057 (CI-1028), a new synthetic thrombin inhibitor, in a rabbit model of thrombosis: comparison with inogatran. J Thromb Thrombolysis. 2001 Feb;11(1):19-31. DOI:10.1023/a:1008900109285

inogatran Preparation Products And Raw materials

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inogatran Suppliers

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155415-08-0, inogatranRelated Search:

N-ethylpiperidine-2-carboxamide METHYL[(1-PROPYLPIPERIDIN-2-YL)METHYL]AMINE (1-BUTYL-2-PIPERIDINYL)-N-METHYLMETHANAMINE N-[(1-BUTYL-2-PIPERIDINYL)METHYL]ETHANAMINE N-[(1-ETHYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE ETHYL[(1-ETHYLPIPERIDIN-2-YL)METHYL]AMINE Pipecolamide N-[(1-PROPYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE N-methylpiperidine-2-carboxamide ETHYL[(1-METHYLPIPERIDIN-2-YL)METHYL]AMINE N-[(1-METHYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE ETHYL[(1-PROPYLPIPERIDIN-2-YL)METHYL]AMINE inogatran N-[(1-BUTYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE AKOS BC-0095 CHEMBRDG-BB 4015189

inogatran

H-314-27

Glycine, N-[(1R)-2-[(2S)-2-[[[3-[(aminoiminomethyl)amino]propyl]amino]carbonyl]-1-piperidinyl]-1-(cyclohexylmethyl)-2-oxoethyl]-

Inogatran (H-314-27)

155415-08-0