3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
- Product Name
- 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
- CAS No.
- 38309-60-3
- Chemical Name
- 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
- Synonyms
- 3H-Spiro[2-benzofuran-1,4'-piperidine;3H-spiro[isobenzofuran-1,4'-piperidine;3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE];3H-spiro[isobenzofuran-1,4'-piperidine];Spiro[isobenzofuran-1(3H),4'-piperidine];spiro[isobenzofuran-1(3H),4'-piperidine] hydrobroMide;3H-Spiro[2-benzofuran-1,4′-piperidine], CAS 38309-60-3
- CBNumber
- CB6132635
- Molecular Formula
- C12H15NO
- Formula Weight
- 189.25
- MOL File
- 38309-60-3.mol
3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] Property
- Melting point:
- 84-86 °C
- Boiling point:
- 321.3±42.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 10.17±0.20(Predicted)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
N-Bromosuccinimide Price
- Product number
- S699885
- Product name
- 3H-Spiro[2-benzofuran-1,4''-piperidine]
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 072834
- Product name
- 3H-Spiro[2-benzofuran-1,4'-piperidine]
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- W5907
- Product name
- 3H-Spiro[2-benzofuran-1,4'-piperidine]
- Packaging
- 1g
- Price
- $272
- Updated
- 2021/12/16
- Product number
- 072834
- Product name
- 3H-Spiro[2-benzofuran-1,4'-piperidine]
- Purity
- 95+%
- Packaging
- 1g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- CHM0094119
- Product name
- 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1070.84
- Updated
- 2021/12/16
3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] Chemical Properties,Usage,Production
Synthesis
37663-43-7
38309-60-3
Step 3: 1'-(phenylmethyl)spiro[isophenylurea-1(3H),4'-piperidine] (119 g, 425.9 mmol) was dissolved in ethanol (1 L) and nickel ruanne (12 g) was added and stirred for 1 h at room temperature under argon protection to remove impurities that may poison the catalyst. Subsequently, nickel ruanne was removed by filtration and the filtrate was transferred to a steel autoclave, 10% Pd/C (Degussa Nr. 1835) (12 g) was added, and hydrogenated at 5 bar hydrogen pressure and 40 °C for 19 h. HPLC analysis showed that 2.7% of the starting material remained unreacted. Therefore, the catalyst was removed by filtration and fresh 10% Pd/C (4 g) was added to the filtrate and hydrogenation was continued under the same conditions for 24 h. The catalyst was removed by filtration and the catalyst was added to the filtrate. Upon completion of the reaction, the catalyst was removed by filtration and the ethanol was removed by evaporation to give a light yellow oily substance. The oily substance was co-stirred with heptane (1 L) and spontaneously crystallized to give the white solid product 3H-spiro[2-benzofuran-1,4'-piperidine] (65 g, 80% yield). Mass spectrometry: m/z = 190 [M + H]+.
References
[1] Patent: US2008/171759, 2008, A1. Location in patent: Page/Page column 20
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 14, p. 5080 - 5095
3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] manufacturers
- Product
- 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] 38309-60-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-16
- Product
- 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] 38309-60-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-10