SIRAMESINE

Product Name: SIRAMESINE
CAS No.: 147817-50-3
Chemical Name: SIRAMESINE
Synonyms: CS-1476;SIRAMESINE;1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine];1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine;1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine];Spiro[isobenzofuran-1(3H),4'-piperidine], 1'-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl]-;1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]-1-butyl]spiro[isobenzofuran-1(3H),4'-piperidine];1'-(4-(1-(4-FLUOROPHENYL)-1H-INDOL-3-YL)BUTYL)-3H-SPIRO[ISOBENZOFURAN-1,4'-PIPERIDINE].HCL
CBNumber: CB52446500
Molecular Formula: C30H31FN2O
Formula Weight: 454.58
MOL File: 147817-50-3.mol

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SIRAMESINE Property

Boiling point:: 611.4±55.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO (up to at least 25 mg/ml)
pka: 9.45±0.20(Predicted)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI: InChI=1S/C30H31FN2O/c31-25-12-14-26(15-13-25)33-21-23(27-9-2-4-11-29(27)33)7-5-6-18-32-19-16-30(17-20-32)28-10-3-1-8-24(28)22-34-30/h1-4,8-15,21H,5-7,16-20,22H2
InChIKey: XWAONOGAGZNUSF-UHFFFAOYSA-N
SMILES: C12(CCN(CCCCC3C4=C(N(C5=CC=C(F)C=C5)C=3)C=CC=C4)CC1)C1=C(C=CC=C1)CO2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B1297
Product name: Siramesine
Packaging: 5mg
Price: $258
Updated: 2021/12/16

ApexBio Technology

Product number: B1297
Product name: Siramesine
Packaging: 10mg
Price: $391
Updated: 2021/12/16

ApexBio Technology

Product number: B1297
Product name: Siramesine
Packaging: 25mg
Price: $567
Updated: 2021/12/16

ApexBio Technology

Product number: B1297
Product name: Siramesine
Packaging: 50mg
Price: $927
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181320
Product name: Siramesine
Purity: >98%
Packaging: 100mg
Price: $950.3
Updated: 2021/12/16

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SIRAMESINE Chemical Properties,Usage,Production

Description

Siramesine (Lu 28-179, 147817-50-3) is a σ2 selective agonist?(IC50’s: σ1 = 17nM, σ2 = 0.2nM).1?It produced non-sedating potent and long-last anxiolytic effects in rodents.2?Siramesine induced caspase-independent programmed cell death in various cancer cell lines?via?increased levels of ROS and lysosomal leakage.3,4,5?Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.6

Uses

Treatment of prostate cancer.

brand name

Provenge (Dendreon).

IC 50

Sigma 1 Receptor

References

[1] JENS PERREGAARD. .sigma. Ligands with Subnanomolar Affinity and Preference for the .sigma.2 Binding Site. 1. 3-(.omega.-Aminoalkyl)-1H-indoles[J]. Journal of Medicinal Chemistry, 1995, 38 11: 1998-2008. DOI:10.1021/jm00011a019
[2] C SÁNCHEZ. The selective sigma2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents.[J]. Journal of Pharmacology and Experimental Therapeutics, 1997, 283 3: 1323-1332.
[3] MARIE STAMPE OSTENFELD. Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress.[J]. Cancer research, 2005, 65 19: 8975-8983. DOI:10.1158/0008-5472.can-05-0269
[4] MARIE STAMPE OSTENFELD. Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation.[J]. Autophagy, 2008: 487-499. DOI:10.4161/auto.5774
[5] R F DIELSCHNEIDER. Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism[J]. Leukemia, 2016, 30 6: 1290-1300. DOI:10.1038/leu.2016.4
[6] M HAFNER ČESEN. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes[J]. Cell Death & Disease, 2013, 4 10: e818-e818. DOI:10.1038/cddis.2013.361

SIRAMESINE Preparation Products And Raw materials

Raw materials

Preparation Products

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SIRAMESINE Suppliers

China 61 India 1 United States 11 Global 73

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 998
Advantage: 56

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
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CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

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View Lastest Price from SIRAMESINE manufacturers

Career Henan Chemical Co

Product: SIRAMESINE 147817-50-3
Price: US $5.50/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1kg,10kg,100kg
Release date: 2020-01-09

147817-50-3, SIRAMESINERelated Search:

Cholesterol TYRPHOSTIN AG 879 Ko 143 ZM 336372 (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT SiraMesine, Lu-28-179 N-CARBOBENZOXY-DL-LEUCINE Valine 1-(4-FLUOROPHENYL)PYRROLE N 570 4-(2-methylphenyl)-4-piperidinol 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] SIRAMESINE

CS-1476

SIRAMESINE

1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine]

1'-(4-(1-(4-FLUOROPHENYL)-1H-INDOL-3-YL)BUTYL)-3H-SPIRO[ISOBENZOFURAN-1,4'-PIPERIDINE].HCL

1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]-1-butyl]spiro[isobenzofuran-1(3H),4'-piperidine]

1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine]

Spiro[isobenzofuran-1(3H),4'-piperidine], 1'-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl]-

1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine

147817-50-3

C30H31FN2O