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SIRAMESINE

Product Name
SIRAMESINE
CAS No.
147817-50-3
Chemical Name
SIRAMESINE
Synonyms
CS-1476;SIRAMESINE;1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine];1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine;1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine];Spiro[isobenzofuran-1(3H),4'-piperidine], 1'-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl]-;1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]-1-butyl]spiro[isobenzofuran-1(3H),4'-piperidine];1'-(4-(1-(4-FLUOROPHENYL)-1H-INDOL-3-YL)BUTYL)-3H-SPIRO[ISOBENZOFURAN-1,4'-PIPERIDINE].HCL
CBNumber
CB52446500
Molecular Formula
C30H31FN2O
Formula Weight
454.58
MOL File
147817-50-3.mol
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SIRAMESINE Property

Boiling point:
611.4±55.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (up to at least 25 mg/ml)
pka
9.45±0.20(Predicted)
form 
solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B1297
Product name
Siramesine
Packaging
5mg
Price
$258
Updated
2021/12/16
ApexBio Technology
Product number
B1297
Product name
Siramesine
Packaging
10mg
Price
$391
Updated
2021/12/16
ApexBio Technology
Product number
B1297
Product name
Siramesine
Packaging
25mg
Price
$567
Updated
2021/12/16
ApexBio Technology
Product number
B1297
Product name
Siramesine
Packaging
50mg
Price
$927
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181320
Product name
Siramesine
Purity
>98%
Packaging
100mg
Price
$950.3
Updated
2021/12/16
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SIRAMESINE Chemical Properties,Usage,Production

Description

Siramesine (Lu 28-179, 147817-50-3) is a σ2 selective agonist?(IC50’s: σ1 = 17nM, σ2 = 0.2nM).1?It produced non-sedating potent and long-last anxiolytic effects in rodents.2?Siramesine induced caspase-independent programmed cell death in various cancer cell lines?via?increased levels of ROS and lysosomal leakage.3,4,5?Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.6

Uses

Treatment of prostate cancer.

brand name

Provenge (Dendreon).

References

1) Perregaard?et al.?(1995),?Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles; J. Med. Chem.?38?1998 2) Sanchez?et al.?(1997),?The selective sigma2-ligand Lu 280179 has potent anxiolytic effects in rodents; J. Pharmacol. Exp. Ther.?283?1323 3) Ostenfeld?et al.?(2005),?Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress;?Cancer Res.?65?8975 4) Ostenfeld et al. (2008),?Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation; Autophagy?4?487 5) Dielschneider?et al.?(2016),?Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism; Leukemia?30?1290 6) Cesen?et al.?(2013),?Siramesine triggers cell death through destabilization of mitochondria, but not lysosomes; Cell Death Dis.?4?e818

SIRAMESINE Preparation Products And Raw materials

Raw materials

Preparation Products

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SIRAMESINE Suppliers

China 48 India 1 United States 11 Global 60
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View Lastest Price from SIRAMESINE manufacturers

Career Henan Chemical Co
Product
SIRAMESINE 147817-50-3
Price
US $5.50/g
Min. Order
1g
Purity
98%
Supply Ability
1kg,10kg,100kg
Release date
2020-01-09

147817-50-3, SIRAMESINERelated Search:

TYRPHOSTIN AG 879 Ko 143 ZM 336372 (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT SiraMesine, Lu-28-179 Cholesterol N-CARBOBENZOXY-DL-LEUCINE Valine 1-(4-FLUOROPHENYL)PYRROLE N 570 4-(2-methylphenyl)-4-piperidinol 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] SIRAMESINE

  • CS-1476
  • SIRAMESINE
  • 1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine]
  • 1'-(4-(1-(4-FLUOROPHENYL)-1H-INDOL-3-YL)BUTYL)-3H-SPIRO[ISOBENZOFURAN-1,4'-PIPERIDINE].HCL
  • 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]-1-butyl]spiro[isobenzofuran-1(3H),4'-piperidine]
  • 1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine]
  • Spiro[isobenzofuran-1(3H),4'-piperidine], 1'-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl]-
  • 1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine
  • 147817-50-3
  • C30H31FN2O