SIRAMESINE
- Product Name
- SIRAMESINE
- CAS No.
- 147817-50-3
- Chemical Name
- SIRAMESINE
- Synonyms
- CS-1476;SIRAMESINE;1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine];1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine;1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine];Spiro[isobenzofuran-1(3H),4'-piperidine], 1'-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl]-;1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]-1-butyl]spiro[isobenzofuran-1(3H),4'-piperidine];1'-(4-(1-(4-FLUOROPHENYL)-1H-INDOL-3-YL)BUTYL)-3H-SPIRO[ISOBENZOFURAN-1,4'-PIPERIDINE].HCL
- CBNumber
- CB52446500
- Molecular Formula
- C30H31FN2O
- Formula Weight
- 454.58
- MOL File
- 147817-50-3.mol
SIRAMESINE Property
- Boiling point:
- 611.4±55.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO (up to at least 25 mg/ml)
- pka
- 9.45±0.20(Predicted)
- form
- solid
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B1297
- Product name
- Siramesine
- Packaging
- 5mg
- Price
- $258
- Updated
- 2021/12/16
- Product number
- B1297
- Product name
- Siramesine
- Packaging
- 10mg
- Price
- $391
- Updated
- 2021/12/16
- Product number
- B1297
- Product name
- Siramesine
- Packaging
- 25mg
- Price
- $567
- Updated
- 2021/12/16
- Product number
- B1297
- Product name
- Siramesine
- Packaging
- 50mg
- Price
- $927
- Updated
- 2021/12/16
- Product number
- orb181320
- Product name
- Siramesine
- Purity
- >98%
- Packaging
- 100mg
- Price
- $950.3
- Updated
- 2021/12/16
SIRAMESINE Chemical Properties,Usage,Production
Description
Siramesine (Lu 28-179, 147817-50-3) is a σ2 selective agonist?(IC50’s: σ1 = 17nM, σ2 = 0.2nM).1?It produced non-sedating potent and long-last anxiolytic effects in rodents.2?Siramesine induced caspase-independent programmed cell death in various cancer cell lines?via?increased levels of ROS and lysosomal leakage.3,4,5?Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.6
Uses
Treatment of prostate cancer.
brand name
Provenge (Dendreon).
References
1) Perregaard?et al.?(1995),?Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles; J. Med. Chem.?38?1998 2) Sanchez?et al.?(1997),?The selective sigma2-ligand Lu 280179 has potent anxiolytic effects in rodents; J. Pharmacol. Exp. Ther.?283?1323 3) Ostenfeld?et al.?(2005),?Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress;?Cancer Res.?65?8975 4) Ostenfeld et al. (2008),?Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation; Autophagy?4?487 5) Dielschneider?et al.?(2016),?Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism; Leukemia?30?1290 6) Cesen?et al.?(2013),?Siramesine triggers cell death through destabilization of mitochondria, but not lysosomes; Cell Death Dis.?4?e818
SIRAMESINE Preparation Products And Raw materials
Raw materials
Preparation Products
SIRAMESINE Suppliers
- Tel
- --
- Fax
- --
- info@chemsworth.com
- Country
- India
- ProdList
- 6700
- Advantage
- 30
View Lastest Price from SIRAMESINE manufacturers
- Product
- SIRAMESINE 147817-50-3
- Price
- US $5.50/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1kg,10kg,100kg
- Release date
- 2020-01-09