2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE
- Product Name
- 2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE
- CAS No.
- 37859-43-1
- Chemical Name
- 2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE
- Synonyms
- 2-(CHLOROMETHYL)BENZO[D]THIAZOLE;NSC 201711;BUTTPARK 77\08-26;CHEMBRDG-BB 4016924;2-CHLOROMETHYL-BENZOTHIAZOLE;Benzothiazole, 2-(chloromethyl)-;2-(Chloromethyl)benzothiazole,95%;2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE;Benzothiazole, 2-(chloromethyl)- (7CI,9CI)
- CBNumber
- CB6133283
- Molecular Formula
- C8H6ClNS
- Formula Weight
- 183.66
- MOL File
- 37859-43-1.mol
2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE Property
- Melting point:
- 34℃
- Boiling point:
- 102°/0.5mm
- Density
- 1.371
- Flash point:
- 120℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- soluble in Methanol
- form
- Solid
- pka
- 0.43±0.10(Predicted)
- Appearance
- Off-white to light yellow <34°C Solid,>34°C Liquid
- Sensitive
- Moisture Sensitive
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41-43
- Safety Statements
- 26-36/37-39
- HazardClass
- IRRITANT
- HS Code
- 2934208090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C3335
- Product name
- 2-(Chloromethyl)benzothiazole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $68
- Updated
- 2025/07/31
- Product number
- C587915
- Product name
- 2-(Chloromethyl)-1,3-benzothiazole
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C587915
- Product name
- 2-(Chloromethyl)-1,3-benzothiazole
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC134270
- Product name
- 2-(Chloromethyl)-1,3-benzothiazole
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- X0138
- Product name
- 2-(Chloromethyl)-1,3-benzothiazole
- Packaging
- 1g
- Price
- $93
- Updated
- 2021/12/16
2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE Chemical Properties,Usage,Production
Synthesis Reference(s)
Synthetic Communications, 19, p. 2921, 1989 DOI: 10.1080/00397918908052683
Synthesis
37859-42-0
37859-43-1
General procedure for the synthesis of 2-(chloromethyl)-1,3-benzothiazole from 2-hydroxymethylbenzothiazole: To a stirred solution containing 2-hydroxymethylbenzothiazole (2.5 g, 15.1 mmol), triphenylphosphine (4.89 g, 18.6 mmol), and anhydrous toluene (50 ml) was added, protected by nitrogen, carbon tetrachloride (15.0 ml, 155 mmol ). The reaction mixture was heated to reflux for 5 hours. After completion of the reaction, the reaction mixture was concentrated using a rotary evaporator to give the crude product. The crude product was purified by rapid chromatography on silica gel to afford 2-(chloromethyl)-1,3-benzothiazole (2.36 g, 85% yield) using 100% dichloromethane as eluent. The product was confirmed by mass spectrometry (ion spray): m/z = 183.9 (M + 1); 1H NMR (CDCl3) data were as follows: δ= 8.04-8.01 (1H, m), 7.91-7.89 (1H, m), 7.53-7.49 (1H, m), 7.44-7.40 (1H, m), 4.95 (2H, s).
References
[1] Tetrahedron, 1988, vol. 44, # 7, p. 2021 - 2032
[2] Chemical Communications, 2017, vol. 53, # 54, p. 7545 - 7548
[3] Patent: WO2005/92885, 2005, A1. Location in patent: Page/Page column 55
[4] Zhurnal Obshchei Khimii, 1954, vol. 24, p. 1664,1667; engl. Ausg. 1645, 1647
[5] Zhurnal Obshchei Khimii, 1956, vol. 26, p. 797,798; engl. Ausg. 911, 912
2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE manufacturers
- Product
- 2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE 37859-43-1
- Price
- US $31.00-1.50/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-10
- Product
- 2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE 37859-43-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-(CHLOROMETHYL)-1,3-BENZOTHIAZOLE 37859-43-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09