N-desferriferrichrome Property

Melting point:

197-203°C

storage temp. 

2-8°C

solubility 

DMSO, Methanol

form 

Solid

color 

White to Off-White

Safety

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

N-desferriferrichrome Chemical Properties,Usage,Production

Description

Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms. It can be utilized as a heterologous siderophore by bacteria, including P. aeruginosa and V. parahaemolyticus. Ferrichrome (0.8 μM) inhibits proliferation of murine spleen mononuclear cells induced by concanavalin A and reduces the number of concanavalin A-stimulated CD4⁺ T cells expressing the IL-2 receptor. It also inhibits heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.

Uses

Growth-promoting iron chelator. Ferrichrome iron-free from Ustilago sphaerogena.

Definition

ChEBI: A homodetic cyclic peptide composed from two units of three glycyl and three N5-acetyl-N5-hydroxy-L-ornithyl residues.

Biochem/physiol Actions

Growth-promoting iron chelator