1'-Hydroxybufuralol

Product Name: 1'-Hydroxybufuralol
CAS No.: 57704-16-2
Chemical Name: 1'-Hydroxybufuralol
Synonyms: Ro 03-7410;1'-Hydroxybufuralol;1'-Hydroxy bufuralol;1'-hydroxy Bufuralol (Ro 03-7410);Bufuralol Impurity 3(Mixture of Diastereomers);1'-Hydroxy Bufuralol (Mixture of Diastereomers);1’-Hydroxy Bufuralol (Mixture of Diastereomers);α2-[[(1,1-DiMethylethyl)aMino]Methyl]-α7-Methyl-;Bufuralol Impurity 3-d9(Mixture of Diastereomers);2-(tert-Butylamino)-1-[7-(1-hydroxyethyl)-1-benzofuran-2-yl]ethanol
CBNumber: CB61356399
Molecular Formula: C16H23NO3
Formula Weight: 277.36
MOL File: 57704-16-2.mol

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1'-Hydroxybufuralol Property

Melting point:: 41-49°C
Boiling point:: 433.0±40.0 °C(Predicted)
Density: 1.139±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 13.58±0.20(Predicted)
color: Off-White to Beige
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22160
Product name: 1'-hydroxy Bufuralol
Purity: ≥97%
Packaging: 500μg
Price: $189
Updated: 2024/03/01

Cayman Chemical

Product number: 22160
Product name: 1'-hydroxy Bufuralol
Purity: ≥97%
Packaging: 1mg
Price: $359
Updated: 2024/03/01

TRC

Product number: H830480
Product name: 1’-HydroxyBufuralol(MixtureofDiastereomers)
Packaging: 10mg
Price: $1390
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: MTB0000024
Product name: HYDROXYBUFURALOL MALEATE SALT
Purity: 95.00%
Packaging: 5MG
Price: $1650.39
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: MTB0000024
Product name: HYDROXYBUFURALOL MALEATE SALT
Purity: 95.00%
Packaging: 10MG
Price: $2322.42
Updated: 2021/12/16

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1'-Hydroxybufuralol Chemical Properties,Usage,Production

Description

1’-hydroxy Bufuralol is a metabolite of bufuralol . Bufuralol is metabolized by the cytochrome P450 isoforms 2D1 and 2D2 (CYP2D1/2); therefore, quantification of the bufuralol metabolite, 1’-hydroxy bufuralol, can be used to determine CYP2D1/2 enzyme activity in humans and rats.

Chemical Properties

White to Off-White Solid

Uses

A metabolite of Bufuralol, a β-Adrenergic blocker with peripheral vasodilating activity.

IC 50

CYP2

References

[1] EVANGELOS P DASKALOPOULOS. D?-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D.[J]. Molecular Pharmacology, 2012, 82 4: 668-678. DOI: 10.1124/mol.112.078709
[2] H YAMAZAKI. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.[J]. Molecular Pharmacology, 1994, 46 3: 568-577.

1'-Hydroxybufuralol Preparation Products And Raw materials

Raw materials

Preparation Products

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1'-Hydroxybufuralol Suppliers

Canada 1 China 26 India 3 United Kingdom 1 United States 9 Global 40

J & K SCIENTIFIC LTD.

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Lynnchem

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Novachemistry

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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57704-16-2, 1'-HydroxybufuralolRelated Search:

2-(4-Aminophenyl)ethanol Propanolol Bisoprolol Atenolol tert-Butanol Propranolol hydrochloride Ethyl acetate Metoprolol 2-(METHYLSULFONYL)ETHANOL 2,2-Diethoxyethylamine Acebutolol Tetrahydrofuran Monoethanolamine Metoprolol tartrate 2-Dimethylaminoethanol Diethylaminoethanol (+/-)-BUFURALOL HYDROCHLORIDE 1'-Hydroxybufuralol

Ro 03-7410

2-(tert-Butylamino)-1-[7-(1-hydroxyethyl)-1-benzofuran-2-yl]ethanol

1’-Hydroxy Bufuralol (Mixture of Diastereomers)

1'-Hydroxybufuralol

α2-[[(1,1-DiMethylethyl)aMino]Methyl]-α7-Methyl-

2-(tert- Butylamino)-1-(7-(1- hydroxyethyl)benzofuran-2- yl)ethanol maleate

Bufuralol Impurity 3(Mixture of Diastereomers)

Bufuralol Impurity 3-d9(Mixture of Diastereomers)

2,7-Benzofurandimethanol, α2-[[(1,1-dimethylethyl)amino]methyl]-α7-methyl-

1'-Hydroxy bufuralol

1'-Hydroxy Bufuralol (Mixture of Diastereomers)

1'-hydroxy Bufuralol (Ro 03-7410)

57704-16-2

Aromatics

Heterocycles

Metabolites & Impurities