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NF 279

Product Name
NF 279
CAS No.
202983-32-2
Chemical Name
NF 279
Synonyms
NF 279;CS-319;NF279 - CAS 202983-32-2 - Calbiochem;8,8[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhex;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid;8,8'-(CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO))BIS-1,3,5-NAPHTHALENETRISULFONIC ACID, NA;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid sodium salt;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhexasodiumsalt;8,8'-[CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO)]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID HEXASODIUM SALT;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid hexasodium salt
CBNumber
CB6135641
Molecular Formula
C49H37N6NaO23S6
Formula Weight
1293.2
MOL File
202983-32-2.mol
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NF 279 Property

storage temp. 
Desiccate at -20°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
White solid
color 
White to off-white
Water Solubility 
Soluble to 25 mM in water
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
480418
Product name
NF279 - CAS 202983-32-2 - Calbiochem<br />A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC /KB ~ 1 μM in smooth muscle).
Packaging
5mg
Price
$251
Updated
2024/03/01
Tocris
Product number
1199
Product name
NF279
Purity
≥95%(HPLC)
Packaging
50
Price
$887
Updated
2021/12/16
Tocris
Product number
1199
Product name
NF279
Purity
≥95%(HPLC)
Packaging
10
Price
$212
Updated
2021/12/16
TRC
Product number
N391680
Product name
NF279
Packaging
250mg
Price
$2065
Updated
2021/12/16
Usbiological
Product number
255973
Product name
NF 279
Packaging
10mg
Price
$466
Updated
2021/12/16
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NF 279 Chemical Properties,Usage,Production

Uses

NF 279 is a potent and selective P2X1 antagonist.

General Description

A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~1 μM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no discernible effects on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62 μM and >300 μM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 ? rat P2X2 > rat P2X3 ~human P2X7 ? human P2X4. Not degraded by ecto-nucleotidases.

Biological Activity

A potent and selective P2X 1 antagonist (IC 50 = 19 nM). Displays good selectivity over P2X 2 ,(IC 50 = 0.76 μ M), P2X 3 (IC 50 = 1.62 μ M), P2X 4 (IC 50 > 300 μ M), P2Y receptors and ecto-nucleotidases.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

NF 279 Preparation Products And Raw materials

Raw materials

Preparation Products

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NF 279 Suppliers

AdooQ BioScience, LLC
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+1 (866) 333-9607
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United States
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Cckinase, Inc.
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+1 (732)236-3202
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sales@cckinase.com
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ApexBio Technology
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Alfa Chemistry
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United States Biological
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chemicals@usbio.net
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United States
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MedChemExpress
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Riedel-de Haen AG
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Santa Cruz Biotechnology, Inc.
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EMD Biosciences, Inc.
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technical@calbiochem.com
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United States
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202983-32-2, NF 279Related Search:


  • NF 279
  • 8,8'-(CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO))BIS-1,3,5-NAPHTHALENETRISULFONIC ACID, NA
  • 8,8'-[CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO)]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID HEXASODIUM SALT
  • NF279 - CAS 202983-32-2 - Calbiochem
  • CS-319
  • 8,8[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhex
  • 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid hexasodium salt
  • 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid
  • 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid sodium salt
  • 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhexasodiumsalt
  • 202983-32-2
  • C49H30N4Na6O21S6
  • C49H30N6O23S66Na
  • C49H30N6Na6O23S6
  • Purinergics P2 receptor