OPC 21268

Product Name: OPC 21268
CAS No.: 131631-89-5
Chemical Name: OPC 21268
Synonyms: CS-2724;Fuscoside;OPC 21268;OPC-21268 hydrate;Fuscoside, 10 mM in DMSO;OPC 21268;OPC-21268;OPC21268;Inhibitor,Vasopressin Receptor,OPC21268,Fuscoside,OPC-21268,inhibit;1-[1-[4-(3-Acetylaminopropoxy)benzoyl]-4-piperidyl]-3,4-dihydroquinolin-2(1H)-one;1-{1-[4(3-acetylaminopropoxy)benzoyl]-4-piperidyl}-3,4-dihydro-2(1H)-quinolinone hydrate;N-[3-[4-[4-(2-oxo-3,4-dihydroquinolin-1-yl)piperidine-1-carbonyl]phenoxy]propyl]acetamide
CBNumber: CB61356814
Molecular Formula: C26H31N3O4
Formula Weight: 449.54
MOL File: 131631-89-5.mol

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OPC 21268 Property

Boiling point:: 772.5±60.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥20mg/mL
pka: 16.17±0.46(Predicted)
form: powder
color: white to off-white

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O1016
Product name: OPC-21268 hydrate
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $756
Updated: 2025/07/31

Sigma-Aldrich

Product number: O1016
Product name: OPC-21268 hydrate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $267
Updated: 2023/01/07

Cayman Chemical

Product number: 27226
Product name: OPC 21268
Packaging: 10mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 27226
Product name: OPC 21268
Packaging: 25mg
Price: $606
Updated: 2024/03/01

Cayman Chemical

Product number: 27226
Product name: OPC 21268
Packaging: 5mg
Price: $153
Updated: 2024/03/01

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OPC 21268 Chemical Properties,Usage,Production

Description

OPC 21268 is a nonpeptide antagonist of vasopressin V₁ receptors (IC₅₀ = 0.4 μM in rat liver membranes). It is selective for V₁ over V₂ receptors (IC₅₀ = >100 μM in kidney membranes). It is also selective for rat over human V₁ receptors (K_is = 25 and 8,800 nM, respectively), which can be partially attributed to the alanine residue at position 337 of the rat sequence, instead of a glycine residue in the human sequence, with differences at positions 224, 310, and 324 also contributing. OPC 21268 (0.03-1 mg/kg, i.v.) inhibits pressor responses induced by arginine vasopressin (argipressin; ) in pithed rats and arginine vasopressin-induced vasoconstriction in conscious rats (ID₅₀ = 2 mg/kg). It induces hypotension in aged spontaneously hypertensive rats (SHRs) and stroke-prone SHRs when administered at a dose of 3 mg/kg.

Uses

OPC 21268 is a nonpeptide AVP (Vasopressin) Receptor V antagonist.

storage

Store at +4°C

References

[1] M THIBONNIER. A molecular model of agonist and nonpeptide antagonist binding to the human V(1) vascular vasopressin receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 294 1: 195-203.
[2] YOSHITAKA YAMAMURA. OPC-21268, an Orally Effective, Nonpeptide Vasopressin V1 Receptor Antagonist[J]. Science, 1991, 252 5005. DOI: 10.1126/science.1850553
[3] Y YAMADA. OPC-21268, a vasopressin V1 antagonist, produces hypotension in spontaneously hypertensive rats.[J]. Hypertension, 1994, 23 2: 200-204. DOI: 10.1161/01.hyp.23.2.200

OPC 21268 Preparation Products And Raw materials

Raw materials

Preparation Products

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OPC 21268 Suppliers

China 71 United Kingdom 1 United States 11 USA 1 Global 84

Shanghai Boyle Chemical Co., Ltd.

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131631-89-5, OPC 21268Related Search:

1-[1-[4-(3-Acetylaminopropoxy)benzoyl]-4-piperidyl]-3,4-dihydroquinolin-2(1H)-one

1-{1-[4(3-acetylaminopropoxy)benzoyl]-4-piperidyl}-3,4-dihydro-2(1H)-quinolinone hydrate

N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide hydrate

OPC-21268 hydrate

N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]acetamide

OPC 21268

N-[3-[4-[4-(2-oxo-3,4-dihydroquinolin-1-yl)piperidine-1-carbonyl]phenoxy]propyl]acetamide

OPC 21268;OPC-21268;OPC21268

CS-2724

Fuscoside

Acetamide, N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-

Inhibitor,Vasopressin Receptor,OPC21268,Fuscoside,OPC-21268,inhibit

N-(3-{4-[4-(2-oxo-1,2,3,4-tetrahydroquinolin-1-yl)piperidine-1-carbonyl]phenoxy}propyl)acetamide

Fuscoside, 10 mM in DMSO

131631-89-5