M 8218

Product Name: M 8218
CAS No.: 87827-02-9
Chemical Name: M 8218
Synonyms: M 8218;BENC-003;Penehyclidine;M 8218 / Penehyclidine;Benzenemethanol, α-[(1-azabicyclo[2.2.2]oct-3-yloxy)methyl]-α-cyclopentyl-;benzeneMethanol, a-[(1-azabicyclo[2.2.2]oct-3-yloxy)Methyl]-a-cyclopentyl- hydrochloride
CBNumber: CB61374391
Molecular Formula: C20H29NO2
Formula Weight: 315.45
MOL File: 87827-02-9.mol

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M 8218 Property

Boiling point:: 461.0±35.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
pka: 13?+-.0.29(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AvaChem

Product number: 3000B
Product name: Penequine
Packaging: 5mg
Price: $119
Updated: 2021/12/16

AvaChem

Product number: 3000B
Product name: Penequine
Packaging: 10mg
Price: $189
Updated: 2021/12/16

AvaChem

Product number: 3000B
Product name: Penequine
Packaging: 100mg
Price: $390
Updated: 2021/12/16

AvaChem

Product number: 3000B
Product name: Penequine
Packaging: 1g
Price: $950
Updated: 2021/12/16

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M 8218 Chemical Properties,Usage,Production

Uses

Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1][2].

IC 50

mAChR1; mAChR3; NF-κB

References

[1] Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885. DOI:10.2147/COPD.S295329
[2] Xiao HT, et al. Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors. Drug Des Devel Ther. 2012;6:317-22. DOI:10.2147/DDDT.S36555

M 8218 Preparation Products And Raw materials

Raw materials

Preparation Products

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M 8218 Suppliers

China 15 United States 2 Global 17

Hangzhou Sage Chemical Co., Ltd.

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Chengdu DingDang Pharmaceutical Co., Ltd.

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Shanghai Dexuan Pharmaceutical Technology Co., Ltd

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87827-02-9, M 8218Related Search:

SuMatriptan N-Oxide HYDRAZINE Penehyclidine IMpurity N-DesMethyl SuMatriptan Benzeneacetaldehyde, α-cyclopentyl- [3-[2-(diMethylaMino)ethyl]-2-[[3-[2-(diMethylaMino)ethyl]-1H-indol-5-yl]Methyl]-1H-indol-5-yl]-N-MethylMethanesulfonaMide, succinate salt 3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide Penehyclidine Impurity 18 4-Hydrazinyl-1-phthalazinaMine Penehyclidine HCl (Mixture of IsoMers) Sumatriptan EP Impurity H Dihydralazine sulphate Hydralazine Tazobactam Impurity B Sumatriptan succinate

M 8218

benzeneMethanol, a-[(1-azabicyclo[2.2.2]oct-3-yloxy)Methyl]-a-cyclopentyl- hydrochloride

Penehyclidine

BENC-003

Benzenemethanol, α-[(1-azabicyclo[2.2.2]oct-3-yloxy)methyl]-α-cyclopentyl-

M 8218 / Penehyclidine

87827-02-9

C20H29NO2HCl