Penehyclidine HCl (Mixture of IsoMers)

Product Name: Penehyclidine HCl (Mixture of IsoMers)
CAS No.: 151937-76-7
Chemical Name: Penehyclidine HCl (Mixture of IsoMers)
Synonyms: Penehyclidine HCl;Penehyclidine HCl (Mixture of IsoMers);Penehyclidine hydrochloride, 10 mM in DMSO;Penehyclidine hydrochloride (mixture of isomers);2-(1-azabicyclo[2.2.2]oct-3-yloxy)-1-cyclopentyl-1-phenyleth...;1-Cyclopentyl-1-phenyl-2-(quinuclidin-3-yloxy)ethanol hydrochloride;2-(1-azabicyclo[2.2.2]octan-3-yloxy)-1-cyclopentyl-1-phenylethanol,hydrochloride;2-(1-azabicyclo[2.2.2]oct-3-yloxy)-1-cyclopentyl-1-phenylethanol hydrochloride (1:1);Benzenemethanol, a-[(1-azabicyclo[2.2.2]oct-3-yloxy)methyl]-a-cyclopentyl-, hydrochloride(1:1)
CBNumber: CB32675283
Molecular Formula: C20H30ClNO2
Formula Weight: 351.92
MOL File: 151937-76-7.mol

More

Less

Penehyclidine HCl (Mixture of IsoMers) Property

storage temp.: -20°C, away from moisture
form: Liquid
color: Colorless to light yellow
Water Solubility: H2O: 2mg/mL, clear
InChI: InChI=1S/C20H29NO2.ClH/c22-20(18-8-4-5-9-18,17-6-2-1-3-7-17)15-23-19-14-21-12-10-16(19)11-13-21;/h1-3,6-7,16,18-19,22H,4-5,8-15H2;1H
InChIKey: DDTVVMRZNVIVQM-UHFFFAOYSA-N
SMILES: C(C1C=CC=CC=1)(C1CCCC1)(O)COC1CN2CCC1CC2.Cl

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

AvaChem

Product number: 3000
Product name: Penequine Hydrochloride
Packaging: 5mg
Price: $119
Updated: 2021/12/16

AvaChem

Product number: 3000
Product name: Penequine Hydrochloride
Packaging: 10mg
Price: $189
Updated: 2021/12/16

AvaChem

Product number: 3000
Product name: Penequine Hydrochloride
Packaging: 100mg
Price: $390
Updated: 2021/12/16

AvaChem

Product number: 3000
Product name: Penequine Hydrochloride
Packaging: 1g
Price: $950
Updated: 2021/12/16

More

Less

Penehyclidine HCl (Mixture of IsoMers) Chemical Properties,Usage,Production

Uses

Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1].

Biological Activity

Penehyclidine hydrochloride is a brain penetrant anticholinergic drug th at exhibits both antimuscarinic and antinicotinic activity. Penehyclidine hydrochloride does not induce muscarinic 2 receptor-associated cardiovascular side effects. Penehyclidine hydrochloride is effective in experimental models of heart, lung and brain ischemia reperfusion injury.

in vivo

Penehyclidine (0.3-3 mg/kg, ip, single dose) exhibits protective activity in rats ALI models^[2].
Penehyclidine (1 mg/kg, ip, single dose) enhances the expression of BDNF and phosphorylation of ERK1/2 in the hippocampus, exhibits antidepressant-like effects in mouse CUMS model^[4].

Animal Model:	rats ALI models^[2]
Dosage:	0.3-3 mg/kg
Administration:	ip, single dose
Result:	Alleviated LPS-induced lung injury in rats.

Animal Model:	Mouse chronic unpredictable mild stress (CUMS) model^[4]
Dosage:	1 mg/kg
Administration:	ip, single dose
Result:	Reduced the immobility time in the forced swimming test (FST) and tail suspension test (TST).

IC 50

mAChR1; mAChR3; NF-κB

References

[1] Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885. DOI:10.2147/COPD.S295329
[2] Wang X, et al., Penehyclidine hydrochloride alleviates lipopolysaccharide?induced acute respiratory distress syndrome in cells via regulating autophagy?related pathway. Mol Med Rep. 2021 Feb;23(2):100. DOI:10.3892/mmr.2020.11739
[3] Zi C, et al., Penehyclidine hydrochloride protects against anoxia/reoxygenation injury in cardiomyocytes through ATP-sensitive potassium channels, and the Akt/GSK-3β and Akt/mTOR signaling pathways. Cell Biol Int. 2020 Jun;44(6):1353-1362. DOI:10.1002/cbin.11329
[4] Sun X, et al., A Selective M1 and M3 Receptor Antagonist, Penehyclidine Hydrochloride, Exerts Antidepressant-Like Effect in Mice. Neurochem Res. 2019 Dec;44(12):2723-2732. DOI:10.1007/s11064-019-02891-5

Penehyclidine HCl (Mixture of IsoMers) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Penehyclidine HCl (Mixture of IsoMers) Suppliers

China 68 United States 3 Global 71

Chengdu Lisite Pharmaceutical Co., Ltd.

Tel: 028-85918191
Email: hy@liarma.com
Country: China
ProdList: 9
Advantage: 58

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-0755-28967200-8062 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9624
Advantage: 60

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Hangzhou Guorui Biomedical Technology Co., Ltd.

Tel: +86-571-85183519 +86-571-85182680
Fax: +86-571-85186835
Email: sales@guoruibio.com
Country: CHINA
ProdList: 153
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

More

Less

View Lastest Price from Penehyclidine HCl (Mixture of IsoMers) manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Penehyclidine HCl (Mixture of IsoMers) 151937-76-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-07-04

Career Henan Chemical Co

Product: Penehyclidine HCl (Mixture of IsoMers) 151937-76-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-13

151937-76-7, Penehyclidine HCl (Mixture of IsoMers)Related Search:

FRAXIN Urapidil hydrochloride Flurbiprofen CYCLAZOSIN HYDROCHLORIDE [3-[2-(diMethylaMino)ethyl]-2-[[3-[2-(diMethylaMino)ethyl]-1H-indol-5-yl]Methyl]-1H-indol-5-yl]-N-MethylMethanesulfonaMide, succinate salt 3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide Penehyclidine Impurity 18 4-Hydrazinyl-1-phthalazinaMine Sumatriptan EP Impurity H Dihydralazine sulphate Hydralazine Tazobactam Impurity B Sumatriptan succinate SuMatriptan N-Oxide HYDRAZINE Penehyclidine IMpurity N-DesMethyl SuMatriptan M 8218

Penehyclidine HCl (Mixture of IsoMers)

Penehyclidine HCl

2-(1-azabicyclo[2.2.2]octan-3-yloxy)-1-cyclopentyl-1-phenylethanol,hydrochloride

2-(1-azabicyclo[2.2.2]oct-3-yloxy)-1-cyclopentyl-1-phenylethanol hydrochloride (1:1)

2-(1-azabicyclo[2.2.2]oct-3-yloxy)-1-cyclopentyl-1-phenyleth...

1-Cyclopentyl-1-phenyl-2-(quinuclidin-3-yloxy)ethanol hydrochloride

Benzenemethanol, a-[(1-azabicyclo[2.2.2]oct-3-yloxy)methyl]-a-cyclopentyl-, hydrochloride(1:1)

Penehyclidine hydrochloride, 10 mM in DMSO

Penehyclidine hydrochloride (mixture of isomers)

151937-76-7