FRAXIN

Product Name: FRAXIN
CAS No.: 524-30-1
Chemical Name: FRAXIN
Synonyms: FRAXIN;Paviin;Fraxoside;FRAXIN(P);Fraxin-RM;FRAXIN WITH HPLC;FRAXIN USP/EP/BP;Fraxin (Fraxoside;Fraxetol8-glucoside;FRAXETIN-8-GLUCOSIDE
CBNumber: CB8445599
Molecular Formula: C16H18O10
Formula Weight: 370.31
MOL File: 524-30-1.mol

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FRAXIN Property

Melting point:: 205-208°C
Boiling point:: 420.23°C (rough estimate)
Density: 1.4066 (rough estimate)
refractive index: 1.5376 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO : 250 mg/mL (675.11 mM; Need ultrasonic)
form: Solid
pka: 6.99±0.20(Predicted)
color: White
Major Application: food and beverages
InChI: InChI=1/C16H18O10/c1-23-7-4-6-2-3-9(18)25-14(6)15(11(7)20)26-16-13(22)12(21)10(19)8(5-17)24-16/h2-4,8,10,12-13,16-17,19-22H,5H2,1H3/t8-,10-,12+,13-,16+/s3
InChIKey: CRSFLLTWRCYNNX-JAAAIXMONA-N
SMILES: C12OC(=O)C=CC=1C=C(OC)C(O)=C2O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O |&1:15,16,18,19,21,r|
LogP: -1.930 (est)

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Safety

WGK Germany: 3
RTECS: DJ3091000
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89545
Product name: Fraxin
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $277
Updated: 2025/07/31

Sigma-Aldrich

Product number: 80533
Product name: Fraxin
Purity: analytical standard
Packaging: 10mg
Price: $388
Updated: 2022/05/15

Cayman Chemical

Product number: 28217
Product name: Fraxin
Packaging: 5mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 28217
Product name: Fraxin
Packaging: 50mg
Price: $648
Updated: 2024/03/01

Cayman Chemical

Product number: 28217
Product name: Fraxin
Packaging: 10mg
Price: $195
Updated: 2024/03/01

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FRAXIN Chemical Properties,Usage,Production

Chemical Properties

Slightly soluble in cold water, soluble in hot water and hot ethanol, practically insoluble in ether. Derived from the dried bark of the ash tree of the family Mulleinaceae, the pointed leaf ash or the persistent column ash

Uses

food and beverages

Definition

ChEBI: Fraxin is a beta-D-glucoside that is fraxetin attached to a beta-D-glucopyranosyl group at position 8 via a glycosidic linkage. It is a natural product isolated from the leaves of Fraxinus excelsior and exhibits potent hepatoprotective effects in vitro and in vivo. It has a role as a plant metabolite, an anti-inflammatory agent and a hepatoprotective agent. It is a beta-D-glucoside, a hydroxycoumarin and an aromatic ether. It is functionally related to a fraxetin.

Synthesis

A method for extracting high-purity Qinpi methanin and Qinpi glucoside from Qinpi, characterized in that it comprises the steps of:

(1) using methanol or water conventional method to obtain Qinpi extract containing Qinpi methylin, Qinpi glycoside and other different mass concentrations;

(2) prepare a biphasic system and separate to obtain the upper and lower phase solutions of the biphasic phase, and dissolve the Qinpi extract repeatedly with the upper phase solution until the Qinpi extract does not contain Qinpi methylin and Qinpi glucoside;

(3) after centrifugation or filtration of the above solution containing qinpi methylin and qinpi glycoside, add 1 to 3 times the amount of the above solution to the lower phase solution, full extraction, until the proportion of solid impurities in the upper phase is no longer significantly reduced, the separation of the upper phase solution obtained, concentrated to obtain the solution containing mainly qinpi methylin and qinpi glycoside;

(4) using conventional means to remove salts and fat-soluble impurity components, concentration, crystallization to obtain high-purity Qinpi methylin and Qinpi glucoside.

in vivo

Fraxin (50 mg/kg, p.o.) significantly blocks the CCl₄-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg, p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver, respectively) compared with the GSSG levels of the CCl₄-treated group^[1].

FRAXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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FRAXIN Suppliers

China 227 France 2 Germany 2 India 1 Switzerland 1 United Kingdom 6 United States 19 Global 258

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Nanjing bingcheng Biotechnology Co., Ltd.

Tel: 18805194892
Email: 2727751293@qq.com
Country: China
ProdList: 171
Advantage: 58

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Shandong Xiya Chemical Co., Ltd

Tel: 13355009207 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4759
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5645
Advantage: 65

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

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View Lastest Price from FRAXIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Fraxin 524-30-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-17

Career Henan Chemical Co

Product: FRAXIN 524-30-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-12

524-30-1, FRAXINRelated Search:

2-Methoxyhydroquinone 2,3-DIMETHOXYTOLUENE METHYL BETA-D-GLUCOPYRANOSIDE FRAXIN 2-(Allyloxy)phenol 2-(3-METHYLPHENOXY)ETHANOL 2-(2-HYDROXYETHOXY)PHENOL 3-Phenoxy-1,2-propanediol 3,4-Dimethoxyphenol 2-ETHOXY-4-METHYLPHENOL 6-Hydroxycoumarin 2-Ethoxyphenol 2-METHOXYPHENYL ACETATE Guaifenesin 3-Butoxyphenol Isofraxidin METHYL BETA-D-GLUCOPYRANOSIDE HEMIHYDRATE 1,2,4-Benzenetriol

Fraxetol8-glucoside

7,8-Dihydroxy-6-methoxycoumarin 8-β-D-glucopyranoside

Fraxetin 8-β-D-glucopyranoside

8-(β-D-Glucopyranosyloxy)-7-hydroxy-6-methoxycoumarin monohydrate

7,8-DIHYDROXY-6-METHOXYCOUMARIN-BETA-D-GLUCOPYRANOSIDE

FRAXETIN-8-GLUCOSIDE

FRAXETIN-8-O-GLUCOSIDE

FRAXIN

8-(beta-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one

FRAXIN WITH HPLC

7,8-DIHYDROXY-6-METHOXYCOUMARIN-beta-D-GLUCOPYRANOSIDE hplc

7,8-Dihydroxy-6-methoxycoumarin 8-β-D-glucopyranoside, 8-(β-D-Glucopyranosyloxy)-7-hydroxy-6-methoxycoumarin

6-Methoxy-7-hydroxy-8-(β-D-glucopyranosyloxy)-2H-1-benzopyran-2-one

8-(β-D-Glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one

7-Hydroxy-6-methoxy-2-oxo-2H-chromen-8-yl beta-D-glucopyranoside

7-Hydroxy-6-methoxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one

Fraxoside

Paviin

FRAXIN(P)

Fraxin, 98%, from Fraxinus chinensis Roxb.

Fraxin (Fraxoside

2H-1-Benzopyran-2-one, 8-(β-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-

FRAXIN USP/EP/BP

7-hydroxy-6-methoxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one

7-Hydroxy-6-methoxy-8-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one

Fraxin-RM

Fraxin, 10 mM in DMSO

8-(-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one

524-30-1

C16H18O10

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Coumarins