ChemicalBook > CAS DataBase List > 1,2,4-Benzenetriol

1,2,4-Benzenetriol

Product Name
1,2,4-Benzenetriol
CAS No.
533-73-3
Chemical Name
1,2,4-Benzenetriol
Synonyms
1,2,4-TRIHYDROXYBENZENE;Benzene-1,2,4-triol;HYDROXYHYDROQUINONE;1,2,4-Benzentril;Phloroglucinol Impurity 5;HHQ;NSC 2818;Oxyhydrochinon;OXYHYDROQUINONE;4-Hydroxycatechol
CBNumber
CB8356419
Molecular Formula
C6H6O3
Formula Weight
126.11
MOL File
533-73-3.mol
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1,2,4-Benzenetriol Property

Melting point:
140 °C (subl.) (lit.)
Boiling point:
194.21°C (rough estimate)
Density 
1.45 g/cm3 (20℃)
refractive index 
1.5627 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Sparingly), Methanol (Slightly)
form 
Solid
pka
9.58±0.10(Predicted)
color 
Plates from Et2O
Water Solubility 
freely soluble
Sensitive 
Air Sensitive
Merck 
14,1073
BRN 
2042863
Stability:
Light Sensitive, Moisture Sensitive
CAS DataBase Reference
533-73-3(CAS DataBase Reference)
NIST Chemistry Reference
1,2,4-Benzenetriol(533-73-3)
EPA Substance Registry System
1,2,4-Benzenetriol (533-73-3)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-37/38-41-36/37/38-20/21/22
Safety Statements 
26-39-36/37/39-22
WGK Germany 
3
RTECS 
DC4200000
Hazard Note 
Irritant/Keep Cold/Air Sensitive
TSCA 
Yes
HS Code 
2907 29 00
Toxicity
oms-hmn:lym 50 mmol/L CNREA8 45,2471,85
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.43791
Product name
1,2,4-Trihydroxybenzene
Purity
for synthesis
Packaging
5G
Price
$196
Updated
2024/03/01
Sigma-Aldrich
Product number
8.43791
Product name
1,2,4-Trihydroxybenzene
Purity
for synthesis
Packaging
25g
Price
$439
Updated
2024/03/01
Sigma-Aldrich
Product number
173401
Product name
1,2,4-Benzenetriol
Purity
ReagentPlus , 99%
Packaging
1g
Price
$89.1
Updated
2024/03/01
Sigma-Aldrich
Product number
173401
Product name
1,2,4-Benzenetriol
Purity
ReagentPlus , 99%
Packaging
5g
Price
$306
Updated
2024/03/01
TCI Chemical
Product number
H0249
Product name
1,2,4-Trihydroxybenzene
Purity
>98.0%(GC)
Packaging
10g
Price
$138
Updated
2024/03/01
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1,2,4-Benzenetriol Chemical Properties,Usage,Production

Chemical Properties

Gray powder

Physical properties

1,2,4-Benzenetriol forms colorless platelets or prisms that quickly colorize in air. It is soluble in water and polar solvents, and slightly soluble in chloroform and carbon disulfide.

Uses

1,2,4-Trihydroxybenzene is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.It is used as a metabolite of benzene.

Definition

ChEBI: Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.

Production Methods

1,2,4-Benzenetriol is synthesized by hydrolysis of 1,2,4-triacetoxybenzene, which is prepared by the acid-catalyzed reaction of p-benzoquinone with acetic anhydride.
Other production methods for 1,2,4-Benzenetriol are oxidation of resorcinol with hydrogen peroxide and Dakin oxidation of 2,4- or 3,4-dihydroxybenzaldehydes or 2,4- or 3,4-dihydroxyacetophenones with alkaline hydrogen peroxide solution.

General Description

1,2,4-Benzenetriol is also known as hydroxyhydroquinone. It is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.

Chemical Reactivity

1,2,4-Benzenetriol is, like other phenols, a strong reducing agent. Its basic aqueous solution absorbs gaseous oxygen to produce black precipitates of the humic acid type. 1,2,4-Benzenetriol shows typical reactions of phenols. Derivatives of the tautomeric keto form are also known: halogenation of hydroxyhydroquinone, for example, gives 1,2,5,5-tetrahalocyclohexene-3,4,6-trione. Condensation with ethylacetoacetate produces dihydroxycoumarin; reaction with phthalic anhydride yields hydroxyhydroquinonephthalein. Monosubstitution of a hydroxy group by an amino group occurs easily at room temperature and gives 2,4-dihydroxyaniline.

Safety Profile

Poison by subcutaneous and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Crystallise the triol from Et2O or Et2O/EtOH, and dry it in a vacuum. The picrate forms orange-red needles m 96o. [Beilstein 6 H 1087, 6 I 541, 6 II 1071, 6 III 6276.]

1,2,4-Benzenetriol Preparation Products And Raw materials

Raw materials

1,2,4-Triacetoxybenzene Triester 1,4-Benzoquinone

Preparation Products

2,4,5-TRIHYDROXYBENZALDEHYDE
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1,2,4-Benzenetriol Suppliers

Americas 1 Canada 2 China 274 Europe 2 France 2 Germany 3 India 10 Japan 2 Slovakia 1 Switzerland 4 Ukraine 1 United Kingdom 16 United States 42 Global 360
Wuhan Vanzpharm Inc.
Tel
027-84492310 13657243668
Fax
027-84492310
Email
wangting@vanzpharm.com
Country
China
ProdList
50
Advantage
58
Ningbo Agracechem Technology Co., Ltd.
Tel
0574-87621641 13989375151
Email
tianze@agracechem.com
Country
China
ProdList
33
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
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View Lastest Price from 1,2,4-Benzenetriol manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
1,2,4-Benzenetriol 533-73-3
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-09
Hebei Longbang Technology Co., Ltd
Product
1,2,4-Benzenetriol 533-73-3
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-26
Hebei Jingbo New Material Technology Co., Ltd
Product
1,2,4-Benzenetriol 533-73-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000000
Release date
2023-12-25

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