1,2,4-Benzenetriol

Product Name: 1,2,4-Benzenetriol
CAS No.: 533-73-3
Chemical Name: 1,2,4-Benzenetriol
Synonyms: 1,2,4-TRIHYDROXYBENZENE;Benzene-1,2,4-triol;HYDROXYHYDROQUINONE;1,2,4-Benzentril;Phloroglucinol Impurity 5;HHQ;NSC 2818;Oxyhydrochinon;OXYHYDROQUINONE;4-Hydroxycatechol
CBNumber: CB8356419
Molecular Formula: C6H6O3
Formula Weight: 126.11
MOL File: 533-73-3.mol

More

Less

1,2,4-Benzenetriol Property

Melting point:: 140 °C (subl.) (lit.)
Boiling point:: 194.21°C (rough estimate)
Density: 1.45 g/cm3 (20℃)
refractive index: 1.5627 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Solid
pka: 9.58±0.10(Predicted)
color: Plates from Et2O
Water Solubility: freely soluble
Sensitive: Air Sensitive
Merck: 14,1073
BRN: 2042863
Stability:: Light Sensitive, Moisture Sensitive
CAS DataBase Reference: 533-73-3(CAS DataBase Reference)
NIST Chemistry Reference: 1,2,4-Benzenetriol(533-73-3)
EPA Substance Registry System: 1,2,4-Benzenetriol (533-73-3)

More

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41-36/37/38-20/21/22
Safety Statements: 26-39-36/37/39-22
WGK Germany: 3
RTECS: DC4200000
Hazard Note: Irritant/Keep Cold/Air Sensitive
TSCA: Yes
HS Code: 2907 29 00
Toxicity: oms-hmn:lym 50 mmol/L CNREA8 45,2471,85

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.43791
Product name: 1,2,4-Trihydroxybenzene
Purity: for synthesis
Packaging: 5G
Price: $196
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.43791
Product name: 1,2,4-Trihydroxybenzene
Purity: for synthesis
Packaging: 25g
Price: $439
Updated: 2024/03/01

Sigma-Aldrich

Product number: 173401
Product name: 1,2,4-Benzenetriol
Purity: ReagentPlus , 99%
Packaging: 1g
Price: $89.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 173401
Product name: 1,2,4-Benzenetriol
Purity: ReagentPlus , 99%
Packaging: 5g
Price: $306
Updated: 2024/03/01

TCI Chemical

Product number: H0249
Product name: 1,2,4-Trihydroxybenzene
Purity: >98.0%(GC)
Packaging: 10g
Price: $138
Updated: 2024/03/01

More

Less

1,2,4-Benzenetriol Chemical Properties,Usage,Production

Chemical Properties

Gray powder

Physical properties

1,2,4-Benzenetriol forms colorless platelets or prisms that quickly colorize in air. It is soluble in water and polar solvents, and slightly soluble in chloroform and carbon disulfide.

Uses

1,2,4-Trihydroxybenzene is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.It is used as a metabolite of benzene.

Definition

ChEBI: Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.

Production Methods

1,2,4-Benzenetriol is synthesized by hydrolysis of 1,2,4-triacetoxybenzene, which is prepared by the acid-catalyzed reaction of p-benzoquinone with acetic anhydride.
Other production methods for 1,2,4-Benzenetriol are oxidation of resorcinol with hydrogen peroxide and Dakin oxidation of 2,4- or 3,4-dihydroxybenzaldehydes or 2,4- or 3,4-dihydroxyacetophenones with alkaline hydrogen peroxide solution.

General Description

1,2,4-Benzenetriol is also known as hydroxyhydroquinone. It is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.

Chemical Reactivity

1,2,4-Benzenetriol is, like other phenols, a strong reducing agent. Its basic aqueous solution absorbs gaseous oxygen to produce black precipitates of the humic acid type. 1,2,4-Benzenetriol shows typical reactions of phenols. Derivatives of the tautomeric keto form are also known: halogenation of hydroxyhydroquinone, for example, gives 1,2,5,5-tetrahalocyclohexene-3,4,6-trione. Condensation with ethylacetoacetate produces dihydroxycoumarin; reaction with phthalic anhydride yields hydroxyhydroquinonephthalein. Monosubstitution of a hydroxy group by an amino group occurs easily at room temperature and gives 2,4-dihydroxyaniline.

Safety Profile

Poison by subcutaneous and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Crystallise the triol from Et2O or Et2O/EtOH, and dry it in a vacuum. The picrate forms orange-red needles m 96o. [Beilstein 6 H 1087, 6 I 541, 6 II 1071, 6 III 6276.]

1,2,4-Benzenetriol Preparation Products And Raw materials

Raw materials

1,2,4-Triacetoxybenzene Triester 1,4-Benzoquinone

Preparation Products

2,4,5-TRIHYDROXYBENZALDEHYDE

More

Less

1,2,4-Benzenetriol Suppliers

Americas 1 Canada 2 China 260 Europe 2 France 2 Germany 3 India 10 Japan 2 Slovakia 1 Switzerland 4 Ukraine 1 United Kingdom 16 United States 42 Global 346

Wuhan Vanzpharm Inc.

Tel: 027-84492310 13657243668
Fax: 027-84492310
Email: wangting@vanzpharm.com
Country: China
ProdList: 53
Advantage: 58

Ningbo Agracechem Technology Co., Ltd.

Tel: 0574-87621641 13989375151
Email: tianze@agracechem.com
Country: China
ProdList: 34
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12426
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

More

Less

View Lastest Price from 1,2,4-Benzenetriol manufacturers

Hebei Kangcang new material Technology Co., LTD

Product: 1,2,4-Trihydroxybenzene 533-73-3
Price: US $9.00-70.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10 tons
Release date: 2024-03-27

Hebei Saisier Technology Co., LTD

Product: 1,2,4-Benzenetriol 533-73-3
Price: US $6.00/KG
Min. Order: 1KG
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-04-16

Hebei Jingbo New Material Technology Co., Ltd

Product: 1,2,4-Benzenetriol 533-73-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000000
Release date: 2023-12-25

533-73-3, 1,2,4-BenzenetriolRelated Search:

Trimellitic Anhydride Lumefantrine 4-Hydroxybenzoic acid Triethylene glycol 4-Hydroxy-D-(-)-2-phenylglycine 3-Hydroxybenzoic acid Tamoxifen Benzene Triclosan 4-Methoxyphenol Methylparaben 2-Hydroxyphenylacetic acid 4-Cyanophenol 4-Hydroxybenzaldehyde 1,3,5-Trimethoxybenzene 1,2,3-Benzenetriol 1,2,3-BENZENETRIOL-4-CARBOXYLIC ACID 1,3,5-benzenetriol, anhydrous

OXYHYDROQUINONE

1,2,4-TRIHYDROXYBENZENE

1,2,4-BENZENETRIOL

1,3,4-Benzenetriol

1,3,4-Trihydroxybenzene

2,5-Dihydroxyphenol

2-Hydroxy-1,4-hydroquinone

Hydroquinone, hydroxy-

hydroxy-hydroquinon

Oxyhydrochinon

HYDROXYHYDROQUINONE

Benzene-1,2,4-triol

1,2,4-BENZENETRIOL 99%

1,2,4-Trihydroxybenzene,99%

1,2,4-Benzenetriol~Hydroxyhydroquinone

1,2,4-Trihydroxybenzoic acid

1,2,4-Benzentril

1,2,4-Trihydroxybenzene 99%

Benzene-1,3,4-triol

1,2,4-Benzenetriol,95%

1,2,4-Benzenetriol,99%

1,2,4-BENZENETRIOL (1,2,4-TRIHYDROXYBENZENE)

2-Hydroxyhydroquinone

2-Hydroxy-p-benzohydroquinone

4-Hydroxycatechol

HHQ

NSC 2818

1,2,4-TRIHYDROXYBENZENE / 1,2,4-BENZENETRIOL

1,2,4-three benzenephenol

1,2,4-Benzenetriol ReagentPlus(R), 99%

1,2,4-Trihydroxybenzene, 95+%

1,2,4-Trihydroxybene

1,2,4-Benzenetriol Vetec(TM) reagent grade, 98%

1,2,4-Trihydroxybenzene for synthesis

Phloroglucinol Impurity E

Phloroglucinol Impurity 5

1,2,4-Trihydroxybenzene&gt

Phloroglucinol EP Impurity E

1,2,4-Trihydroxybenzene (Paroxetine Impurity)

Paroxetine impurities780

1,2,4-thihydroxy benzene hair dye intermediate

Phloroglucinol Impurity 5 (Phloroglucinol EP Impurity E)

533-73-3

Aromatic Hydrocarbons (substituted) & Derivatives

Aromatics Compounds

Aromatics

Metabolites & Impurities

bc0001