M 8218
- Product Name
- M 8218
- CAS No.
- 87827-02-9
- Chemical Name
- M 8218
- Synonyms
- M 8218;BENC-003;Penehyclidine;M 8218 / Penehyclidine;Benzenemethanol, α-[(1-azabicyclo[2.2.2]oct-3-yloxy)methyl]-α-cyclopentyl-;benzeneMethanol, a-[(1-azabicyclo[2.2.2]oct-3-yloxy)Methyl]-a-cyclopentyl- hydrochloride
- CBNumber
- CB61374391
- Molecular Formula
- C20H29NO2
- Formula Weight
- 315.45
- MOL File
- 87827-02-9.mol
M 8218 Property
- Boiling point:
- 461.0±35.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- pka
- 13?+-.0.29(Predicted)
N-Bromosuccinimide Price
- Product number
- 3000B
- Product name
- Penequine
- Packaging
- 5mg
- Price
- $119
- Updated
- 2021/12/16
- Product number
- 3000B
- Product name
- Penequine
- Packaging
- 10mg
- Price
- $189
- Updated
- 2021/12/16
- Product number
- 3000B
- Product name
- Penequine
- Packaging
- 100mg
- Price
- $390
- Updated
- 2021/12/16
- Product number
- 3000B
- Product name
- Penequine
- Packaging
- 1g
- Price
- $950
- Updated
- 2021/12/16
M 8218 Chemical Properties,Usage,Production
Uses
Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1][2].
IC 50
mAChR1; mAChR3; NF-κB
References
[1] Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885. DOI:10.2147/COPD.S295329
[2] Xiao HT, et al. Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors. Drug Des Devel Ther. 2012;6:317-22. DOI:10.2147/DDDT.S36555
M 8218 Preparation Products And Raw materials
Raw materials
Preparation Products
M 8218 Suppliers
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