ChemicalBook > CAS DataBase List > (R)-5-BROMOMETHYL-2-PYRROLIDINONE

(R)-5-BROMOMETHYL-2-PYRROLIDINONE

Product Name: (R)-5-BROMOMETHYL-2-PYRROLIDINONE
CAS No.: 98612-60-3
Chemical Name: (R)-5-BROMOMETHYL-2-PYRROLIDINONE
Synonyms: B50370;(R)-5-BROMOMETHYL;(R)-5-BROMOMETHYL-2-PYRROLIDINONE;(R)-5-(BroMoMethyl)pyrrolidin-2-one;(5R)-5-(bromomethyl)-2-pyrrolidinone;(5R)-5-(broMoMethyl)pyrrolidin-2-one;[R,(+)]-5α-Bromomethyl-2-pyrrolidone;2-Pyrrolidinone, 5-(bromomethyl)-, (5R)-;[R,(+)]-5α-(Bromomethyl)pyrrolidine-2-one;(R)-5-(Bromomethyl)-2-pyrrolidinone
CBNumber: CB6138167
Molecular Formula: C5H8BrNO
Formula Weight: 178.03
MOL File: 98612-60-3.mol

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(R)-5-BROMOMETHYL-2-PYRROLIDINONE Property

Melting point:: 76-80°C
Boiling point:: 336.1±15.0 °C(Predicted)
Density: 1.541±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 15.39±0.40(Predicted)
form: powder
Appearance: White to off-white Solid
optical activity: [α]22/D +34.0°, c = 0.5 in ethanol

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Safety

Hazard Codes: Xn
Risk Statements: 22-36-43
Safety Statements: 26-36/37
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 715603
Product name: (R)-5-(Bromomethyl)-2-pyrrolidinone
Purity: 96%
Packaging: 250mg
Price: $59.4
Updated: 2023/06/20

TRC

Product number: B697650
Product name: (R)-5-Bromomethyl-2-pyrrolidinone
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B697650
Product name: (R)-5-Bromomethyl-2-pyrrolidinone
Packaging: 1g
Price: $140
Updated: 2021/12/16

TRC

Product number: B697650
Product name: (R)-5-Bromomethyl-2-pyrrolidinone
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK148791
Product name: (R)-(-)-5-Bromomethyl-2-pyrrolidinone
Purity: 97%
Packaging: 1g
Price: $93
Updated: 2021/12/16

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(R)-5-BROMOMETHYL-2-PYRROLIDINONE Chemical Properties,Usage,Production

Chemical Properties

White to tan powder

Synthesis

128899-31-0

98612-60-3

General procedure for the synthesis of (R)-5-bromomethyl-2-pyrrolidinone from (R)-(5-oxopyrrolidin-2-yl)methyl 4-methylbenzenesulfonate: To a solution of (R)-(5-oxopyrrolidin-2-yl)methyl 4-methylbenzenesulfonate (5.0 g, 18.5 mmol) in acetone (10 mL) was added lithium bromide (4.8 g, 55.6 mmol) The reaction mixture was stirred at 80°C overnight. Upon completion of the reaction, the solvent was removed under vacuum and the residue was partitioned between water (50 mL) and ethyl acetate (100 mL). The aqueous layer was extracted with ethyl acetate (2 x 100 mL), the organic phases were combined and dried over anhydrous sodium sulfate. The organic phase was concentrated in vacuo and the residue was purified by column chromatography (using conventional basic activated alumina with the eluent being a mixture of dichloromethane and 0.2-1.0% methanol) to give (R)-5-bromomethyl-2-pyrrolidinone (3.0 g, 90%) as a pale yellow liquid.LCMS (Method F): m/z 178/180 (M + H) + (ES+), retention time 2.24 min, with UV activity.

References

[1] Patent: WO2017/21728, 2017, A1. Location in patent: Page/Page column 45; 46

(R)-5-BROMOMETHYL-2-PYRROLIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-5-BROMOMETHYL-2-PYRROLIDINONE Suppliers

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View Lastest Price from (R)-5-BROMOMETHYL-2-PYRROLIDINONE manufacturers

Career Henan Chemical Co

Product: (R)-5-BROMOMETHYL-2-PYRROLIDINONE 98612-60-3
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-04

98612-60-3, (R)-5-BROMOMETHYL-2-PYRROLIDINONERelated Search:

(S)-5-(BROMOMETHYL)-2-PYRROLIDINONE (R)-5-BROMOMETHYL-2-PYRROLIDINONE Pyrrolidine, 2-(bromomethyl)-

(5R)-5-(broMoMethyl)pyrrolidin-2-one

(R)-5-(BroMoMethyl)pyrrolidin-2-one

(5R)-5-(bromomethyl)-2-pyrrolidinone

(R)-5-BROMOMETHYL-2-PYRROLIDINONE

2-Pyrrolidinone, 5-(bromomethyl)-, (5R)-

[R,(+)]-5α-(Bromomethyl)pyrrolidine-2-one

[R,(+)]-5α-Bromomethyl-2-pyrrolidone

B50370

(R)-5-BROMOMETHYL

(<i>R</i>)-5-(Bromomethyl)-2-pyrrolidinone

98612-60-3

C5H8NOBr

pharmacetical