thielavin A
- Product Name
- thielavin A
- CAS No.
- 71950-66-8
- Chemical Name
- thielavin A
- Synonyms
- thielavin A;4-[(2,4-Dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethylbenzoic acid 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester;Benzoic acid, 4-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethyl-, 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester
- CBNumber
- CB61386873
- Molecular Formula
- C29H30O10
- Formula Weight
- 538.54
- MOL File
- 71950-66-8.mol
thielavin A Property
- Melting point:
- 235-236 °C
- Boiling point:
- 850.0±65.0 °C(Predicted)
- Density
- 1.371±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: souble; DMSO: souble; Ethanol: soluble
- form
- White to off-white powder.
- pka
- 2.82±0.28(Predicted)
N-Bromosuccinimide Price
- Product number
- 21767
- Product name
- Thielavin A
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $352
- Updated
- 2024/03/01
- Product number
- 21767
- Product name
- Thielavin A
- Purity
- ≥95%
- Packaging
- 2.5mg
- Price
- $1402
- Updated
- 2024/03/01
- Product number
- T5006-50
- Product name
- Thielavin A
- Packaging
- 500ug
- Price
- $582
- Updated
- 2021/12/16
- Product number
- T345095
- Product name
- ThielavinA
- Packaging
- 1mg
- Price
- $735
- Updated
- 2021/12/16
- Product number
- 2415CB
- Product name
- ThielavinA
- Packaging
- 2.5mg
- Price
- $1660
- Updated
- 2021/12/16
thielavin A Chemical Properties,Usage,Production
Description
Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 (PGH2; ) and the conversion of PGH2 to PGE2 (; IC50s = 10 and 40 μM, respectively). Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM).
Uses
The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor.
Uses
Thielavin A acts as an inhibitor of prostagladins biosynthesis.
thielavin A Preparation Products And Raw materials
Raw materials
Preparation Products
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