ChemicalBook > CAS DataBase List > Thiotriazinone

Thiotriazinone

Product Name: Thiotriazinone
CAS No.: 58909-39-0
Chemical Name: Thiotriazinone
Synonyms: Ro 11-8390;TTZ,TTA,OHMMT;Triazine acid;THIOTRIAZINONE;Thiotriazinone(TTZ);Thiotriazinone, 98+%;Ceftriaxone EP Impurity C;Ceftriaxone Triazine Analog;Ceftriaxone Sodium USP Impurity D;2-AMINOPROPYL-4(7)-AZO-BENZIMIDAZOLE
CBNumber: CB6138905
Molecular Formula: C4H5N3O2S
Formula Weight: 159.17
MOL File: 58909-39-0.mol

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Thiotriazinone Property

Melting point:: 168-171 °C (lit.)
Density: 1.62±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Solid
pka: 5.34±0.20(Predicted)
color: White to Off-White
InChI: InChI=1S/C4H5N3O2S/c1-7-4(10)5-2(8)3(9)6-7/h1H3,(H,6,9)(H,5,8,10)
InChIKey: UMWWHOXOVPIGFD-UHFFFAOYSA-N
SMILES: N1C(=O)C(=O)NC(=S)N1C
CAS DataBase Reference: 58909-39-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-36
Safety Statements: 36-26
WGK Germany: 3
HS Code: 29336990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 549746
Product name: Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione
Purity: 97%
Packaging: 25g
Price: $413
Updated: 2025/07/31

TRC

Product number: T375300
Product name: Thiotriazinone
Packaging: 100mg
Price: $65
Updated: 2021/12/16

TRC

Product number: T375300
Product name: Thiotriazinone
Packaging: 1g
Price: $70
Updated: 2021/12/16

TRC

Product number: T375300
Product name: Thiotriazinone
Packaging: 50g
Price: $215
Updated: 2021/12/16

TRC

Product number: T375300
Product name: Thiotriazinone
Packaging: 100g
Price: $385
Updated: 2021/12/16

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Thiotriazinone Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Reagent used in the preparation of Cefalosporins.

Uses

Thiotriazinone can be used in the preparation of Cefalosporins.

General Description

Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione is an intermediate for synthesizing ceftriaxone.

Synthesis

6938-68-7

95-92-1

58909-39-0

General procedure for the synthesis of triazine ring from 2-methylaminothiourea and diethyl oxalate: 2-methylaminothiourea, mixed solvent (1:3 mass ratio of methanol to DMSO), diethyl oxalate and sodium methanolate were added to the reactor in the mass ratio 1:10:4:10. The cyclization reaction was carried out in the temperature range of 0-45°C. Upon completion of the reaction, acidification was carried out with hydrochloric acid in an amount of 30% by mass of 2-methylaminothiourea. Subsequently, the reaction mixture was filtered and dried to give the triazine ring in 91.6% yield. The purity of the product was assayed by HPLC and the by-product content was 0.0005% (5 ppm). The product was calculated as M (triazine ring) / [M (methylaminothiourea) * 159.17 / 105.16].

References

[1] Patent: CN104177305, 2017, B. Location in patent: Paragraph 0022; 0023; 0024; 0025; 0026; 0027; 0028-0031

Thiotriazinone Preparation Products And Raw materials

Raw materials

Preparation Products

CEFTRIAXONE

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View Lastest Price from Thiotriazinone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Thiotriazinone 58909-39-0
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-11-25

Hebei Chuanghai Biotechnology Co., Ltd

Product: Thiotriazinone 58909-39-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-28

Shandong Xuhuang New material CoLTD

Product: Thiotriazinone 58909-39-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.99%
Supply Ability: 200
Release date: 2025-02-21

58909-39-0, ThiotriazinoneRelated Search:

CHLOROPHOSPHONAZO III Bensulfuron methyl Dihydromyrcenol Hydrochlorothiazide Mercaptoacetic acid Methyl acrylate Ceftriaxone sodium 1,3,5-Triazine Tetramethylpyrazine Methylparaben Kresoxim-methyl S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate (E)-Ceftriaxone Methyl (6R-trans)-7-amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Malathion CEFTRIAXONE Methyl bromide

2,5-Dihydro-6-hydroxy-3-mercapto-2-methyl-1,2,4-triazine-5-one

TTZ,TTA,OHMMT

Thiotriazinone(TTZ)

3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE[TTZ,OHMMT]

2,5-DIHYDRO-3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE

Thiotriazinone, 98+%

2,5-DIHYDRO-3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE/TTZ

THIOTRIAZINONE/2,5-DIHYDRO-6-HYDROXY-3-MERCAPTO-2-METHYL-5-OXO-1,2,4-TRIAZINE

2-METHYL-3-THIOXOHEXAHYDRO-1,2,4-TRIAZINE-5,6-DIONE(THIOTRIAZINONE)

1,2,4-Triazine-5,6-dione,tetrahydro-2-methyl-3-thioxo-

2-Methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazine-3-thiol

2,5-Dihydro-6-hydroxy-2-methyl-3-mercapto-5-oxo-1,2,3-triazine

2,5-Dihydro-6-hydroxy-2-methyl-3-mercapto-5-oxo-1,2,4-triazione

2-AMINOPROPYL-4(7)-AZO-BENZIMIDAZOLE

3-Mercapto-2-methyl-5-oxo-6-hydroxy-1,2,4-triazine

Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione

THIOTRIAZINONE (3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE)

2-METHYL-3-THIOXO-1,2,5,6-TETRAHYDRO-5,6-DIOXO-1,2,4-TRIAZINE

2-METHYL-5,6-DIOXO-1,2,5,6-TETRAHYDRO-1,2,4-TRIAZINE-3-THIOLCEFATRIAXONE

2-Methyl-3-thioxo-1,2,3,4-tetrahydro-1,2,4-triazine-5,6-dione

Ceftriaxone Triazine Analog

Ceftriaxone EP Impurity C

3-mercapto-2-methyl-1H-triazin-3-ium-5,6-dione

5,6-dihydro-2H-1,2,3,4-thiatriazin-5-one

Ro 11-8390

Ceftriaxone Impurity 3(Ceftriaxone EP Impurity C)

2-Methyl-3-thioxo-1,2,4-triazinane-5,6-dione

2,5-Dihydro-6-Hydroxy-3-Mercapto-2-Methyl-5-oxo-1,2,4-Triazine (TTZ)

THIOTRIAZINONE

3-mercapto-2-methyl-1,2-dihydro-1,2,4-triazine-5,6-dione

TTN 6-Hydroxy-3-Mercapto-2-Methyl-5-oxo-1,2,4-Triazine

3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE USP/EP/BP

2-Methyl-3-sulphanyl-1,2-dihydro-1,2,4-triazin-5,6-dione

2-methyl-3-sulfanylidene-1,2,4-triazinane-5,6-dione

Ceftriaxone Sodium USP Impurity D

Cefazolin oxidation impurities ( TBZL-Na-YH)

2-Methyl-3-sulfanyl-1,2-dihydro-1,2,4-triazine-5,6-dione

Triazine acid

58909-39-0

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