CP 471,474

Product Name: CP 471,474
CAS No.: 210755-45-6
Chemical Name: CP 471,474
Synonyms: CP 471,474;PF-1626077;2-(4-(4-Fluorophenoxy)phenylsulfonamido)-N-hydroxy-2-methylpropanamide;2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide;Propanamide, 2-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methyl-
CBNumber: CB61389258
Molecular Formula: C16H17FN2O5S
Formula Weight: 368.38
MOL File: 210755-45-6.mol

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CP 471,474 Property

Melting point:: 135-137°C (dec.)
Density: 1.375±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: ≥20mg/mL
pka: 9.33±0.50(Predicted)
form: powder
color: white to off-white

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0137
Product name: CP-471474
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0137
Product name: CP-471474
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $404
Updated: 2024/03/01

Cayman Chemical

Product number: 29442
Product name: CP 471,474
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29442
Product name: CP 471,474
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 29442
Product name: CP 471,474
Packaging: 10mg
Price: $153
Updated: 2024/03/01

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CP 471,474 Chemical Properties,Usage,Production

Description

CP 471,474 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with IC₅₀ values of 0.7, 16, 13, and 0.9 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively. It is selective for these MMPs over MMP-1 (IC₅₀ = 1,170 nM). CP 471,474 reduces left ventricular enlargement and decreases the incidence of cardiac rupture in mouse models of myocardial infarction when administered at doses of 120 mg/kg twice per day and 240 mg/kg per day, respectively.

Chemical Properties

White Solid

Uses

A broad spectrum inhibitor of matrix metalloproteinases that attenuates early left ventricular dilation after experimental myocardial infarction in mice. Studies show that it also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.

Biochem/physiol Actions

CP-471474 is a broad spectrum inhibitor of matrix metalloproteinases. CP-471474 has a low nM IC50 efficacy for MMP-2, MMP-3, MMP-9, and MMP-13. CP-471474 has low potency against MMP-1 (IC50 > 1 uM). CP-471474 prevents left ventricular remodeling after experimental myocardial infarction in mice. CP-471474 also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.

CP 471,474 Preparation Products And Raw materials

Raw materials

Preparation Products

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CP 471,474 Suppliers

Canada 1 China 28 India 1 United Kingdom 1 United States 11 Global 42

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
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Chemsky（shanghai）International Co.,Ltd.

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Email: shchemsky@sina.com
Country: China
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
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Sigma-Aldrich

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EMMX Biotechnology LLC

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Shanghai EFE Biological Technology Co., Ltd.

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
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Jiangsu aikang biomedical research and development co., LTD

Tel: 025-66110311 13155353615
Email: qzhang@aikonchem.com
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ProdList: 15527
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
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210755-45-6, CP 471,474Related Search:

4-Fluoro-3-phenoxybenzaldehyde 4-PHENOXYBENZENESULFONYL CHLORIDE 2-Phenoxyethanol

PF-1626077

CP 471,474

2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide

2-(4-(4-Fluorophenoxy)phenylsulfonamido)-N-hydroxy-2-methylpropanamide

Propanamide, 2-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methyl-

210755-45-6

C16H16FN2O5S

Amines

Aromatics

Inhibitors

Intermediates & Fine Chemicals

Pfizer Compounds

Pharmaceuticals

Sulfur & Selenium Compounds

Heterocycles