PKSI 527
- Product Name
- PKSI 527
- CAS No.
- 128837-71-8
- Chemical Name
- PKSI 527
- Synonyms
- PKSI 527,PKSI527;2-[4-[[(2S)-2-[[4-(aminomethyl)cyclohexanecarbonyl]amino]-3-phenylpropanoyl]amino]phenyl]aceticacid,hydrochloride;2-(4-((S)-2-(trans-4-(Aminomethyl)cyclohexane-1-carboxamido)-3-phenylpropanamido)phenyl)acetic acid hydrochloride;Benzeneacetic acid, 4-[[(2S)-2-[[[trans-4-(aminomethyl)cyclohexyl]carbonyl]amino]-1-oxo-3-phenylpropyl]amino]-, hydrochloride (1:1)
- CBNumber
- CB61393901
- Molecular Formula
- C25H31N3O4.ClH
- Formula Weight
- 473.998
- MOL File
- 128837-71-8.mol
PKSI 527 Property
- storage temp.
- -20°C
- solubility
- Soluble in Water (5 mg/ml)
- form
- White solid.
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 23974
- Product name
- PKSI-527
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 23974
- Product name
- PKSI-527
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $505
- Updated
- 2024/03/01
- Product number
- 6192CJ
- Product name
- 2-[4-[[(2S)-2-[[4-(Aminomethyl)cyclohexanecarbonyl]amino]-3-phenylpropanoyl]amino]phenyl]aceticacid;hydrochloride
- Packaging
- 5mg
- Price
- $233
- Updated
- 2021/12/16
- Product number
- INB0000084
- Product name
- PKSI-527
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.38
- Updated
- 2021/12/16
PKSI 527 Chemical Properties,Usage,Production
Description
PKSI-527 (128837-71-8) is a selective plasma kallikrein inhibitor (Ki = 0.81 μM)1 that can be used for affinity purification of kallikrein2.? Synergizes with NO donors to produce antithrombic effects ex-vivo.3? Suppresses collagen-induced arthritis in mouse models.4
References
Wanaka et al. (1992), Synthesis of trans-4-aminomethylcyclohexanecarbonyl-L- and –D-phenylalanine-4-carboxymethylanilide and examination of their inhibitory activity against plasma kallikrein;? ?Chem. Pharm. Bull., 40 1814 Tada et al. (2001), Isolation of plasma kallikrein by high efficiency affinity chromatography and its characterization; Chem. Pharm. Bull., 24 520 Ikarugi et al. (2005), Synergistic antithrombotic effect of a combination of NO donor and plasma kallikrein inhibitor; Thromb. Res., 116 403 Fujimori et al. (1993), Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice; Agents Actions, 39 42
PKSI 527 Preparation Products And Raw materials
Raw materials
Preparation Products
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