PKSI 527
- Product Name
- PKSI 527
- CAS No.
- 128837-71-8
- Chemical Name
- PKSI 527
- Synonyms
- PKSI 527,PKSI527;PKSI-527, plasma kallikrein inhibitor;2-(4-((S)-2-(trans-4-(Aminomethyl)cyclohexane-1-carboxamido)-3-phenylpropanamido)phenyl)acetic acid hydrochloride;2-[4-[[(2S)-2-[[4-(aminomethyl)cyclohexanecarbonyl]amino]-3-phenylpropanoyl]amino]phenyl]aceticacid,hydrochloride;Benzeneacetic acid, 4-[[(2S)-2-[[[trans-4-(aminomethyl)cyclohexyl]carbonyl]amino]-1-oxo-3-phenylpropyl]amino]-, hydrochloride (1:1)
- CBNumber
- CB61393901
- Molecular Formula
- C25H31N3O4.ClH
- Formula Weight
- 473.998
- MOL File
- 128837-71-8.mol
PKSI 527 Property
- storage temp.
- -20°C
- solubility
- Soluble in Water (5 mg/ml)
- form
- White solid.
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 23974
- Product name
- PKSI-527
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 23974
- Product name
- PKSI-527
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $505
- Updated
- 2024/03/01
- Product number
- 6192CJ
- Product name
- 2-[4-[[(2S)-2-[[4-(Aminomethyl)cyclohexanecarbonyl]amino]-3-phenylpropanoyl]amino]phenyl]aceticacid;hydrochloride
- Packaging
- 5mg
- Price
- $233
- Updated
- 2021/12/16
- Product number
- INB0000084
- Product name
- PKSI-527
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.38
- Updated
- 2021/12/16
PKSI 527 Chemical Properties,Usage,Production
Description
PKSI-527 (128837-71-8) is a selective plasma kallikrein inhibitor (Ki = 0.81 μM)1 that can be used for affinity purification of kallikrein2.? Synergizes with NO donors to produce antithrombic effects ex-vivo.3? Suppresses collagen-induced arthritis in mouse models.4
Uses
PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system[1].
References
[1] K WANAKA. Synthesis of trans-4-aminomethylcyclohexanecarbonyl-L- and -D-phenylalanine-4-carboxymethylanilide and examination of their inhibitory activity against plasma kallikrein.[J]. Chemical & pharmaceutical bulletin, 1992, 40 7: 1814-1817. DOI:10.1248/cpb.40.1814
[2] M. TADA. Isolation of plasma kallikrein by high efficiency affinity chromatography and its characterization.[J]. Biological & pharmaceutical bulletin, 2001, 22 1: 520-524. DOI:10.1248/bpb.24.520
[3] HIDEO IKARUGI . Synergistic antithrombotic effect of a combination of NO donor and plasma kallikrein inhibitor[J]. Thrombosis research, 2005, 116 5: Pages 403-408. DOI:10.1016/j.thromres.2005.02.002
[4] 洋一藤森. Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice[C]. 1900: 0. DOI:10.11501/3093809
PKSI 527 Preparation Products And Raw materials
Raw materials
Preparation Products
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