N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride
- Product Name
- N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride
- CAS No.
- 149409-57-4
- Chemical Name
- N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride
- Synonyms
- NE-100;NE100 HCl;NE100;NE 100;NE 100 hydrochloride;4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanaMine;4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanaminehydrochloride;N,N-Di-n-propyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl] ethylamine hydrochloride;N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride;NE100 hydrochloride?,NE100,inhibit,Inhibitor,NE 100 hydrochloride?,Sigma Receptor,NE 100,NE-100
- CBNumber
- CB61400997
- Molecular Formula
- C23H33NO2.HCl
- Formula Weight
- 0
- MOL File
- 149409-57-4.mol
N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride Property
- Melting point:
- 94-96°C
- storage temp.
- 2-8°C
- solubility
- H2O: soluble15mg/mL, clear
- form
- powder
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 19642
- Product name
- NE 100
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19642
- Product name
- NE 100
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 19642
- Product name
- NE 100
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 19642
- Product name
- NE 100
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- 3133
- Product name
- NE100hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $173
- Updated
- 2021/12/16
N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride Chemical Properties,Usage,Production
Description
NE-100 (149409-57-4) is potent inhibitor of the sigma receptor (σ) with selectivity for sigma-1 (IC50?= 1.5 nM) over sigma-2 (IC50?= 85 nM).1,2?NE-100 suppressed ischemia-induced neuronal cell death in mice?via?upregulation of GRP78 through the ATF6 pathway resulting in suppression of ER stress-induced cell death in a sigma-1-independent manner.3
Uses
NE-100 is a potent and selective σ1 receptor antagonist.
Biological Activity
Potent and selective σ 1 receptor antagonist (K i = 0.86 nM) that displays > 55-fold selectivity over σ 2 receptors and > 6000-fold selectivity over D 1 , D 2 , 5-HT 1A , 5-HT 2 and PCP receptors. Exhibits reversible binding (K d = 1.2 nM) and displays antipsychotic activity in vivo . Orally active.
Biochem/physiol Actions
NE-100 is a potent and selective σ1 receptor antagonist with an IC50 value of 1.54 +/- 0.26 nM for σ1 receptors, > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors.
storage
Store at -20°C
References
1) Okuyama?et al.?(1994),?NE-100, a novel sigma receptor ligand: in vivo tests; Life Sci.?53?PL285 2) Chaki?et al.?(1994),?NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain; Eur. J. Pharmacol.?251?R1 3) Ono?et al.?(2013),?A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells; Biochem. Biophys. Res. Commun.?434?904