ChemicalBook > CAS DataBase List > 2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE

2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE

Product Name: 2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
CAS No.: 299442-43-6
Chemical Name: 2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
Synonyms: NKY80;AKOS B003518;VITAS-BB TBB000019;NKY80, 10 mM in DMSO;SALOR-INT L203769-1EA;NKY 80, adenylyl cyclase 5 inhibitor;Adenylyl Cyclase Type V Inhibitor, NKY80;2-amino-7-(2-furyl)-7,8-dihydroquinazolin-5(6H)-one;2-AMINO-7-(FURANYL)-7,8-DIHYDRO-5(6H)-QUINAZOLINONE;2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
CBNumber: CB6144364
Molecular Formula: C12H11N3O2
Formula Weight: 229.23
MOL File: Mol file

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2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Property

Boiling point:: 464.9±47.0 °C(Predicted)
Density: 1.360±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO or methanol
form: powder
pka: 1.85±0.40(Predicted)
color: off-white to light brown
Sensitive: Light Sensitive
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

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Safety

Hazard Codes: Xi,T
Risk Statements: 25
Safety Statements: 45
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 116850
Product name: Adenylyl Cyclase Type V Inhibitor, NKY80
Packaging: 5mg
Price: $102
Updated: 2025/07/31

Sigma-Aldrich

Product number: 116850
Product name: Adenylyl Cyclase Type V Inhibitor, NKY80
Packaging: 25mg
Price: $391
Updated: 2023/06/20

Cayman Chemical

Product number: 17777
Product name: NKY80
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 17777
Product name: NKY80
Purity: ≥98%
Packaging: 5mg
Price: $71
Updated: 2023/06/20

Sigma-Aldrich

Product number: N2165
Product name: NKY80
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $129
Updated: 2022/05/15

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2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Chemical Properties,Usage,Production

Description

NKY-80 (299442-43-6) is a potent and selective adenylyl cyclase inhibitor. Selective for AC5 and over AC3 and AC2 (IC50 = 8.3 μM, 132 μM and 1.7 mM respectively).1,2 More recently shown to indiscriminately inhibit AC6.3 NKY-80 is an extremely useful tool for probing the involvement of adenylyl cyclases in cellular signaling.4

Uses

NKY 80 is an inhibitor of adenylyl cyclase (AC) and displays a greater affinity for AC5 over AC3 and AC2. Adenyl cyclase inhibitors can be easily modified by tumor targeting structures.

General Description

A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC₅₀ = 8.3 μM, 132 μM and 1.7 mM for type V, III and II, respectively) in the presence of G_sα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at +4°C

References

[1] Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms
[2] SANDRA PIERRE. Capturing adenylyl cyclases as potential drug targets[J]. Nature Reviews. Drug Discovery, 2009, 8 4: 321-335. DOI:10.1038/nrd2827
[3] CAMERON S BRAND. Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds.[J]. Journal of Pharmacology and Experimental Therapeutics, 2013, 347 2: 265-275. DOI:10.1124/jpet.113.208157
[4] M CECILIA ORTIZ-CAPISANO. Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells.[J]. Hypertension, 2007, 49 3: 618-624. DOI:10.1161/01.hyp.0000255172.84842.d2

2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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299442-43-6, 2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONERelated Search:

Mycophenolate mofetil ODQ ST034307

2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone

Adenylyl Cyclase Type V Inhibitor, NKY80

2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE

2-AMINO-7-(FURANYL)-7,8-DIHYDRO-5(6H)-QUINAZOLINONE

AKOS B003518

SALOR-INT L203769-1EA

NKY80

VITAS-BB TBB000019

2-amino-7-(2-furyl)-7,8-dihydroquinazolin-5(6H)-one

Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem

5(6H)-Quinazolinone, 2-amino-7-(2-furanyl)-7,8-dihydro-

2-Amino-7-(furan-2-yl)-7,8-dihydroquinazolin-5(6H)-one

NKY 80, adenylyl cyclase 5 inhibitor

NKY80, 10 mM in DMSO

299442-43-6