2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
- Product Name
- 2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
- CAS No.
- 299442-43-6
- Chemical Name
- 2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
- Synonyms
- NKY80;AKOS B003518;VITAS-BB TBB000019;SALOR-INT L203769-1EA;Adenylyl Cyclase Type V Inhibitor, NKY80;2-amino-7-(2-furyl)-7,8-dihydroquinazolin-5(6H)-one;2-AMINO-7-(FURANYL)-7,8-DIHYDRO-5(6H)-QUINAZOLINONE;2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE;2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone;5(6H)-Quinazolinone, 2-amino-7-(2-furanyl)-7,8-dihydro-
- CBNumber
- CB6144364
- Molecular Formula
- C12H11N3O2
- Formula Weight
- 229.23
- MOL File
- Mol file
2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Property
- Boiling point:
- 464.9±47.0 °C(Predicted)
- Density
- 1.360±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO or methanol
- form
- powder
- pka
- 1.85±0.40(Predicted)
- color
- off-white to light brown
- Sensitive
- Light Sensitive
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
N-Bromosuccinimide Price
- Product number
- 116850
- Product name
- Adenylyl Cyclase Type V Inhibitor, NKY80
- Packaging
- 5mg
- Price
- $99.4
- Updated
- 2024/03/01
- Product number
- 116850
- Product name
- Adenylyl Cyclase Type V Inhibitor, NKY80
- Packaging
- 25mg
- Price
- $391
- Updated
- 2023/06/20
- Product number
- J64042
- Product name
- Adenylyl Cyclase Type V Inhibitor, NKY80
- Packaging
- 5mg
- Price
- $112
- Updated
- 2023/06/20
- Product number
- 17777
- Product name
- NKY80
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- 17777
- Product name
- NKY80
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $71
- Updated
- 2023/06/20
2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Chemical Properties,Usage,Production
Description
NKY-80 (299442-43-6) is a potent and selective adenylyl cyclase inhibitor. Selective for AC5 and over AC3 and AC2 (IC50 = 8.3 μM, 132 μM and 1.7 mM respectively).1,2 More recently shown to indiscriminately inhibit AC6.3 NKY-80 is an extremely useful tool for probing the involvement of adenylyl cyclases in cellular signaling.4
Uses
NKY 80 is an inhibitor of adenylyl cyclase (AC) and displays a greater affinity for AC5 over AC3 and AC2. Adenyl cyclase inhibitors can be easily modified by tumor targeting structures.
General Description
A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC50 = 8.3 μM, 132 μM and 1.7 mM for type V, III and II, respectively) in the presence of Gsα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
Biochem/physiol Actions
Cell permeable: yes
storage
Store at +4°C
References
1) Onda?et al. (2001),?Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms; J. Biol. Chem.,?276?47785 2) Pierre?et al. (2009),?Capturing adenylyl cyclases as potential drug targets; Nat. Rev. Drug Discov.,?8?321 3) Brand?et al. (2013),?Isoform selectivity of adenylyl cyclase inhibitor: characterization of known and novel compounds; J. Pharmacol. Exp. Therap.,?347?265 4) Oritz-Capisano?et al. (2007),?Adenylyl cyclase isoform V mediates renin release from juxtaglomerular cells; Hypertension,?49?618