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MYCOPHENOLATE SODIUM

Product Name
MYCOPHENOLATE SODIUM
CAS No.
37415-62-6
Chemical Name
MYCOPHENOLATE SODIUM
Synonyms
Mycophenolate sodium CRS;Mycophenol sodium;sodiummycophenolate;MYCOPHENOLATE SODIUM;Mycophenolic acid sodium;mycophenolicmonosodiumsalt;Mycophenolate Sodium (1448989);mycophenolicacidmonosodiumsalt;Mycophenolate Mofetil EP Impurity F Na salt;Sodium (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate
CBNumber
CB6144485
Molecular Formula
C17H21NaO6
Formula Weight
344.34
MOL File
37415-62-6.mol
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Safety

HS Code 
2932202000
Toxicity
LD50 in mice (mg/kg): 1176±151 orally; 568±53 i.p. (Williams)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

H400Very toxic to aquatic life

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M831505
Product name
MycophenolicAcidMonosodiumSalt
Packaging
2.5mg
Price
$95
Updated
2021/12/16
TRC
Product number
M831505
Product name
MycophenolicAcidMonosodiumSalt
Packaging
10mg
Price
$355
Updated
2021/12/16
AK Scientific
Product number
V1800
Product name
Mycophenolatesodium
Packaging
25mg
Price
$49
Updated
2021/12/16
AvaChem
Product number
1812S
Product name
Mycophenolate Sodium
Packaging
100mg
Price
$49
Updated
2021/12/16
AvaChem
Product number
1812S
Product name
Mycophenolate Sodium
Packaging
1g
Price
$149
Updated
2021/12/16
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MYCOPHENOLATE SODIUM Chemical Properties,Usage,Production

Description

Mycophenolate sodium, an immunosuppressive agent, was launched in Switzerland as an oral treatment in combination with Neoral? and corticosteroids for the prevention of acute transplant rejection in adult patients receiving allogeneic renal transplantation. In contrast to the previously marketed product mycophenolate mofetil (MMF, CellCept?), which is a prodrug and must be converted to mycophenolic acid (MPA) in vivo, Myfortic? contains MPA itself as the active ingredient. Myfortic? was designed to enhance the therapeutic efficacy of MPA through increased tolerability relative to systemic exposure. Unlike MMF, which is absorbed in the stomach, the enteric-coated formulation of MPA sodium is mainly absorbed in the small intestine, thus protecting the upper GI tract from the side effects of MPA. MPA is an inhibitor of inosine monophosphate dehydrogenase (IMDPH), a vital enzyme in the de novo pathway of purine biosynthesis. Proliferating lymphocytes rely principally on this pathway for purine production,thus rendering them succeptible to depletion of purine bases by MPA. Inhibition of IMPDH by MPA results in the inhibition of both T- and B-lymphocyte proliferation upon antigen challenge and facilitates the prevention of acute graft rejection. Following oral administration of MPA sodium, the tmax of MPA is 1.5–2 h, with a mean absolute bioavailability of 71% and a mean half-life of 11.7 h. MPA is primarily metabolized in the liver by glucuronidation and excreted mainly in the urine as the metabolite. The recommended dosage regimen of MPA sodium is 720 mg twice daily, which provides equimolar amounts of MPA compared with MMF 1000 mg twice daily. In two major clinical trials in 748 patients, Myfortic? was demonstrated to be a highly potent and well-tolerated immunosuppressant for new renal transplant patients. A trend was seen towards fewer dose reductions due to GI intolerability and less serious infections relative to other MPA drugs. The most common adverse events associated with MPA treatment are diarrhea and leukopenia.

Originator

Novartis (Switzerland)

Uses

Mycophenolic Acid Monosodium Salt in its enteric-coated form is used as an immunosuppressive agent in organ transplantation and autoimmune diseases.Environmental contaminants; Food contaminants

Uses

Immunosuppressant

Definition

ChEBI: An organic sodium salt that is the sodium salt of mycophenolic acid. An immunosuppressant, it is widely used to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.

brand name

Myfortic

Synthesis

Mycophenolic acid (137) was originally synthesized by Birch and Wright and has been the subject of several total and formal syntheses. The large production in industry is done via fermentation. A concise synthesis of mycophenolic acid published recently is depicted in Scheme 17. Reaction of dimethyl 1,3-acetonedicarboxylate (128) with commercially available geranyl chloride (129) in the presence of NaH gave ketoester 130 in 82% yield. Treatment of ketoester 130 with 4-(pivolyloxy)-2-butynal (131) in the presence of NaH provided resorcinol 132 in a single step with all substituents in place in 33% yield along with two more compounds represented by 133 (62%). Resorcinol 132 was transformed into 134 via a four step sequences: methylation with NaH and MeI in dry DMF, reduction of the formyl group with NaBH4, mesylation of the resulting alcohol and subsequent reduction of the mesylate. The preparation of phthalide 135 was affected in quantitative yield on treatment of 134 with K2CO3 in dry MeOH. Selective ozonolysis of compound 135, followed by Jones oxidation and esterification afforded ester 136. Demethylation with BCl3 in DCM followed by hydrolysis of the ester function gave the mycophenolic acid (137). The mycophenolic acid was then converted to its sodium salt XVII (no conditions and yield available£?.

MYCOPHENOLATE SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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MYCOPHENOLATE SODIUM Suppliers

Chembest Research Laboratories Limited
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Beijing Ouhe Technology Co., Ltd
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LGM Pharma
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United States
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Zhemical Co., Ltd.
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0760-89935616
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+86 (760) 8533-0775
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BOC Sciences
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United States
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Nanjing Sunlida Biological Technology Co., Ltd.
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Suzhou Pharmaceutical Technology co.,ltd
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Shanghai QianJin Chemical Technology Co., Ltd
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Chizhou Kailong Import and Export Trade Co., Ltd.
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View Lastest Price from MYCOPHENOLATE SODIUM manufacturers

Sinoway Industrial co., ltd.
Product
Mycophenolate Sodium 37415-62-6
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
USP
Supply Ability
20 tons
Release date
2021-08-09
shandong perfect biotechnology co.ltd
Product
mycophenolate sodium 37415-62-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
500kg
Release date
2023-11-16
Career Henan Chemical Co
Product
MYCOPHENOLATE SODIUM 37415-62-6
Price
US $1000.00/KG
Min. Order
25KG
Purity
99%
Supply Ability
10tons
Release date
2018-07-26

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