MYCOPHENOLATE SODIUM

ChemicalBook > CAS DataBase List > MYCOPHENOLATE SODIUM

MYCOPHENOLATE SODIUM

Product Name: MYCOPHENOLATE SODIUM
CAS No.: 37415-62-6
Chemical Name: MYCOPHENOLATE SODIUM
Synonyms: Mycophenolate sodium CRS;Mycophenol sodium;sodiummycophenolate;MYCOPHENOLATE SODIUM;Mycophenolic acid sodium;mycophenolicmonosodiumsalt;Mycophenolate Sodium (1448989);mycophenolicacidmonosodiumsalt;Mycophenolate Mofetil EP Impurity F Na salt;Sodium (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate
CBNumber: CB6144485
Molecular Formula: C17H21NaO6
Formula Weight: 344.34
MOL File: 37415-62-6.mol

Less

Safety

HS Code: 2932202000
Toxicity: LD50 in mice (mg/kg): 1176±151 orally; 568±53 i.p. (Williams)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

H400Very toxic to aquatic life

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: M831505
Product name: MycophenolicAcidMonosodiumSalt
Packaging: 2.5mg
Price: $95
Updated: 2021/12/16

TRC

Product number: M831505
Product name: MycophenolicAcidMonosodiumSalt
Packaging: 10mg
Price: $355
Updated: 2021/12/16

AK Scientific

Product number: V1800
Product name: Mycophenolatesodium
Packaging: 25mg
Price: $49
Updated: 2021/12/16

AvaChem

Product number: 1812S
Product name: Mycophenolate Sodium
Packaging: 100mg
Price: $49
Updated: 2021/12/16

AvaChem

Product number: 1812S
Product name: Mycophenolate Sodium
Packaging: 1g
Price: $149
Updated: 2021/12/16

Less

MYCOPHENOLATE SODIUM Chemical Properties,Usage,Production

Description

Mycophenolate sodium, an immunosuppressive agent, was launched in Switzerland as an oral treatment in combination with Neoral^? and corticosteroids for the prevention of acute transplant rejection in adult patients receiving allogeneic renal transplantation. In contrast to the previously marketed product mycophenolate mofetil (MMF, CellCept^?), which is a prodrug and must be converted to mycophenolic acid (MPA) in vivo, Myfortic^? contains MPA itself as the active ingredient. Myfortic^? was designed to enhance the therapeutic efficacy of MPA through increased tolerability relative to systemic exposure. Unlike MMF, which is absorbed in the stomach, the enteric-coated formulation of MPA sodium is mainly absorbed in the small intestine, thus protecting the upper GI tract from the side effects of MPA. MPA is an inhibitor of inosine monophosphate dehydrogenase (IMDPH), a vital enzyme in the de novo pathway of purine biosynthesis. Proliferating lymphocytes rely principally on this pathway for purine production,thus rendering them succeptible to depletion of purine bases by MPA. Inhibition of IMPDH by MPA results in the inhibition of both T- and B-lymphocyte proliferation upon antigen challenge and facilitates the prevention of acute graft rejection. Following oral administration of MPA sodium, the t_max of MPA is 1.5–2 h, with a mean absolute bioavailability of 71% and a mean half-life of 11.7 h. MPA is primarily metabolized in the liver by glucuronidation and excreted mainly in the urine as the metabolite. The recommended dosage regimen of MPA sodium is 720 mg twice daily, which provides equimolar amounts of MPA compared with MMF 1000 mg twice daily. In two major clinical trials in 748 patients, Myfortic^? was demonstrated to be a highly potent and well-tolerated immunosuppressant for new renal transplant patients. A trend was seen towards fewer dose reductions due to GI intolerability and less serious infections relative to other MPA drugs. The most common adverse events associated with MPA treatment are diarrhea and leukopenia.

Originator

Novartis (Switzerland)

Uses

Mycophenolic Acid Monosodium Salt in its enteric-coated form is used as an immunosuppressive agent in organ transplantation and autoimmune diseases.Environmental contaminants; Food contaminants

Uses

Immunosuppressant

Definition

ChEBI: An organic sodium salt that is the sodium salt of mycophenolic acid. An immunosuppressant, it is widely used to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.

brand name

Myfortic

Synthesis

Mycophenolic acid (137) was originally synthesized by Birch and Wright and has been the subject of several total and formal syntheses. The large production in industry is done via fermentation. A concise synthesis of mycophenolic acid published recently is depicted in Scheme 17. Reaction of dimethyl 1,3-acetonedicarboxylate (128) with commercially available geranyl chloride (129) in the presence of NaH gave ketoester 130 in 82% yield. Treatment of ketoester 130 with 4-(pivolyloxy)-2-butynal (131) in the presence of NaH provided resorcinol 132 in a single step with all substituents in place in 33% yield along with two more compounds represented by 133 (62%). Resorcinol 132 was transformed into 134 via a four step sequences: methylation with NaH and MeI in dry DMF, reduction of the formyl group with NaBH4, mesylation of the resulting alcohol and subsequent reduction of the mesylate. The preparation of phthalide 135 was affected in quantitative yield on treatment of 134 with K2CO3 in dry MeOH. Selective ozonolysis of compound 135, followed by Jones oxidation and esterification afforded ester 136. Demethylation with BCl3 in DCM followed by hydrolysis of the ester function gave the mycophenolic acid (137). The mycophenolic acid was then converted to its sodium salt XVII (no conditions and yield available￡?.

MYCOPHENOLATE SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

Less

MYCOPHENOLATE SODIUM Suppliers

Canada 1 China 100 India 20 Israel 1 Italy 1 United States 10 Global 133

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

Zhemical Co., Ltd.

Tel: 0760-89935616
Fax: +86 (760) 8533-0775
Email: zc@zhemical.com
Country: China
ProdList: 172
Advantage: 57

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Suzhou Pharmaceutical Technology co.,ltd

Tel: 0510-88771160 18051901298
Fax: 0510-8877116
Email: 2013446823@qq.com
Country: China
ProdList: 53
Advantage: 61

Shanghai QianJin Chemical Technology Co., Ltd

Tel: 021-20900665 17321230821
Fax: 021-20900665
Email: 2986274987@qq.com
Country: China
ProdList: 891
Advantage: 55

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-66023220 0086-15250997978
Fax: 025-58362220
Email: 1511893459@qq.com
Country: China
ProdList: 7850
Advantage: 55

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5010
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: lucy@atkchemical.com
Country: China
ProdList: 9204
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973186 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 18338
Advantage: 68

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 4015
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28810
Advantage: 58

Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15951
Advantage: 58

Conier Chem & Pharma Limited

Tel: 13368167990
Email: sales@conier.com
Country: China
ProdList: 2830
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83778895 18602735115
Fax: 027-51119224
Email: 18602735115@163.com
Country: China
ProdList: 1993
Advantage: 64

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4877
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7774
Advantage: 58

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Tel: +8617731987558
Email: xingjiu@xingjiubiotech.com
Country: China
ProdList: 989
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15354
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Guangdong Wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886766 13927870850
Fax: 0751-2886756
Email: 3001267247@qq.com
Country: China
ProdList: 9974
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22963
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39894
Advantage: 58

Wuhan Dingtong Pharmaceutical Co., Ltd

Tel: 027-59207795 18327179646
Fax: 027-59207795
Email: 18327179646@163.com
Country: China
ProdList: 1991
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49374
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Shenzhen Jianyi Biotechnology Co., Ltd

Tel: 0755-84826604
Email: 3001783715@qq.com
Country: CHINA
ProdList: 2896
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81145920 13259709322
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10009
Advantage: 58

Shanghai Botuo Biotechnology Co., LTD

Tel: 16621358918
Fax: QQ:402135374
Email: botuopharma888@163.com
Country: China
ProdList: 9208
Advantage: 58

Wuhan Dingxintong Pharmaceutical Co. , Ltd.

Tel: 027-83984790 17720532645
Fax: 027-83984790
Email: t17720532645@163.com
Country: China
ProdList: 983
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4495
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 10784
Advantage: 58

DONBOO AMINO ACID COMPANY

Tel: +8613063595538
Email: donboo@donboo.com
Country: China
ProdList: 9363
Advantage: 58

NORANA GROUP

Tel: 027-027-59209883 17386169806
Fax: 027-59209883
Email: service@nornachem.com
Country: China
ProdList: 4577
Advantage: 58

Hubei yongkuo Technology Co., Ltd

Tel: 027-59223108 15972152991
Fax: 027-59223108
Email: 1248580099@qq.com
Country: China
ProdList: 9988
Advantage: 58

Hubei Xinkang Pharmaceutical Chemical Co., Ltd

Tel: 027-59308705 18871579363
Fax: 027-59308705
Email: 1248180077@qq.com
Country: China
ProdList: 9949
Advantage: 58

Hubei Shishun Biotechnology Co. Ltd

Tel: 027-59223025 15107168801
Fax: 027-59223025
Email: 1718480011@qq.com
Country: China
ProdList: 9867
Advantage: 58

Hubei Baidu Chemical Co., Ltd

Tel: 027-59106051 13627137652
Fax: 027-59223020
Email: 1438180055@qq.com
Country: China
ProdList: 9965
Advantage: 58

Hubei Guangao Biotechnology Co., Ltd

Tel: 027-027-59223056 18162699093
Fax: 027-59223056
Email: 1208480011@qq.com
Country: China
ProdList: 9924
Advantage: 58

Hubei Wande Chemical Co., Ltd

Tel: 027-59210159 15377098680
Fax: 027-59210159
Email: 1148280011@qq.com
Country: China
ProdList: 9961
Advantage: 58

Tianmen Hengchang Chemical Co., Ltd

Tel: 027-59322316 15172518801
Fax: 027-59322316
Email: 1208480077@qq.com
Country: China
ProdList: 9882
Advantage: 58

Hubei Qifei Pharmaceutical Chemical Co., Ltd

Tel: 027-027-59322506 18071128681
Fax: 027-59322506
Email: 1438082200@qq.com
Country: China
ProdList: 9976
Advantage: 58

Less

View Lastest Price from MYCOPHENOLATE SODIUM manufacturers

Sinoway Industrial co., ltd.

Product: Mycophenolate Sodium 37415-62-6
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: USP
Supply Ability: 20 tons
Release date: 2021-08-09

shandong perfect biotechnology co.ltd

Product: mycophenolate sodium 37415-62-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 500kg
Release date: 2023-11-16

Career Henan Chemical Co

Product: MYCOPHENOLATE SODIUM 37415-62-6
Price: US $1000.00/KG
Min. Order: 25KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-07-26

37415-62-6, MYCOPHENOLATE SODIUMRelated Search:

Mycophenolic Acid O-Desmethyl Ether 6-(4,6-DIHYDROXY-7-METHYL-3-OXO-1,3-DIHYDRO-ISOBENZOFURAN-5-YL)-4-METHYL-HEX-4-ENOIC ACID METHYL ESTER Mycophenolic Lactone Ether Kanamycin sulfate Orlistat laundry soap Mycophenolic Acid Sorbitol Ester Mycophenolic Hydroxy Lactone 3,5-Dimethyl-4-methoxybenzoic acid 4-Methoxysalicylic acid 2,5-DIMETHYL-P-ANISALDEHYDE 2,4-DIHYDROXY-3,6-DIMETHYLBENZOIC ACID 2,3-DIMETHYLANISALDEHYDE METHYL 2,4-DIHYDROXY-3-METHYLBENZOATE Mycophenolic acid MYCOPHENOLATE SODIUM 5-HYDROXYPHTHALIDE 4-Methyl-5,7-dihydroxyisobenzofuran-1(3H)-one

mycophenolicacidmonosodiumsalt

mycophenolicmonosodiumsalt

sodiummycophenolate

MYCOPHENOLATE SODIUM

4-Hexenoic acid,6-(1,3-dihydro-4-hydroxy-6-Methoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-,sodiuM salt

4-Hexenoic acid,6-(1,3-dihydro-4-hydroxy-6-Methoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-,sodiuM salt (1:1), (4E)-

(4E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid sodium salt

Mycophenolate sodium CRS

Mycophenolate sodiumQ: What is Mycophenolate sodium Q: What is the CAS Number of Mycophenolate sodium Q: What is the storage condition of Mycophenolate sodium Q: What are the applications of Mycophenolate sodium

Mycophenolate Sodium (1448989)

Mycophenolic acid sodium

Mycophenolate Mofetil EP Impurity F Na salt

Mycophenol sodium

Sodium (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate

37415-62-6

C17H19NaO6

C17H19O6Na