MYCOPHENOLATE SODIUM

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MYCOPHENOLATE SODIUM

Product Name: MYCOPHENOLATE SODIUM
CAS No.: 37415-62-6
Chemical Name: MYCOPHENOLATE SODIUM
Synonyms: Mycophenolate sodium CRS;Mycophenol sodium;sodiummycophenolate;MYCOPHENOLATE SODIUM;Mycophenolic acid sodium;mycophenolicmonosodiumsalt;Mycophenolate Sodium (1448989);mycophenolicacidmonosodiumsalt;Mycophenolate Mofetil EP Impurity F Na salt;4-Hexenoic acid,6-(1,3-dihydro-4-hydroxy-6-Methoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-,sodiuM salt
CBNumber: CB6144485
Molecular Formula: C17H21NaO6
Formula Weight: 344.34
MOL File: 37415-62-6.mol

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Safety

HS Code: 2932202000
Toxicity: LD50 in mice (mg/kg): 1176±151 orally; 568±53 i.p. (Williams)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

H400Very toxic to aquatic life

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M831505
Product name: MycophenolicAcidMonosodiumSalt
Packaging: 2.5mg
Price: $95
Updated: 2021/12/16

TRC

Product number: M831505
Product name: MycophenolicAcidMonosodiumSalt
Packaging: 10mg
Price: $355
Updated: 2021/12/16

AK Scientific

Product number: V1800
Product name: Mycophenolatesodium
Packaging: 25mg
Price: $49
Updated: 2021/12/16

AvaChem

Product number: 1812S
Product name: Mycophenolate Sodium
Packaging: 100mg
Price: $49
Updated: 2021/12/16

AvaChem

Product number: 1812S
Product name: Mycophenolate Sodium
Packaging: 1g
Price: $149
Updated: 2021/12/16

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MYCOPHENOLATE SODIUM Chemical Properties,Usage,Production

Description

Mycophenolate sodium, an immunosuppressive agent, was launched in Switzerland as an oral treatment in combination with Neoral^? and corticosteroids for the prevention of acute transplant rejection in adult patients receiving allogeneic renal transplantation. In contrast to the previously marketed product mycophenolate mofetil (MMF, CellCept^?), which is a prodrug and must be converted to mycophenolic acid (MPA) in vivo, Myfortic^? contains MPA itself as the active ingredient. Myfortic^? was designed to enhance the therapeutic efficacy of MPA through increased tolerability relative to systemic exposure. Unlike MMF, which is absorbed in the stomach, the enteric-coated formulation of MPA sodium is mainly absorbed in the small intestine, thus protecting the upper GI tract from the side effects of MPA. MPA is an inhibitor of inosine monophosphate dehydrogenase (IMDPH), a vital enzyme in the de novo pathway of purine biosynthesis. Proliferating lymphocytes rely principally on this pathway for purine production,thus rendering them succeptible to depletion of purine bases by MPA. Inhibition of IMPDH by MPA results in the inhibition of both T- and B-lymphocyte proliferation upon antigen challenge and facilitates the prevention of acute graft rejection. Following oral administration of MPA sodium, the t_max of MPA is 1.5–2 h, with a mean absolute bioavailability of 71% and a mean half-life of 11.7 h. MPA is primarily metabolized in the liver by glucuronidation and excreted mainly in the urine as the metabolite. The recommended dosage regimen of MPA sodium is 720 mg twice daily, which provides equimolar amounts of MPA compared with MMF 1000 mg twice daily. In two major clinical trials in 748 patients, Myfortic^? was demonstrated to be a highly potent and well-tolerated immunosuppressant for new renal transplant patients. A trend was seen towards fewer dose reductions due to GI intolerability and less serious infections relative to other MPA drugs. The most common adverse events associated with MPA treatment are diarrhea and leukopenia.

Originator

Novartis (Switzerland)

Uses

Mycophenolic Acid Monosodium Salt in its enteric-coated form is used as an immunosuppressive agent in organ transplantation and autoimmune diseases.Environmental contaminants; Food contaminants

Uses

Immunosuppressant

Definition

ChEBI: An organic sodium salt that is the sodium salt of mycophenolic acid. An immunosuppressant, it is widely used to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.

brand name

Myfortic

Synthesis

Mycophenolic acid (137) was originally synthesized by Birch and Wright and has been the subject of several total and formal syntheses. The large production in industry is done via fermentation. A concise synthesis of mycophenolic acid published recently is depicted in Scheme 17. Reaction of dimethyl 1,3-acetonedicarboxylate (128) with commercially available geranyl chloride (129) in the presence of NaH gave ketoester 130 in 82% yield. Treatment of ketoester 130 with 4-(pivolyloxy)-2-butynal (131) in the presence of NaH provided resorcinol 132 in a single step with all substituents in place in 33% yield along with two more compounds represented by 133 (62%). Resorcinol 132 was transformed into 134 via a four step sequences: methylation with NaH and MeI in dry DMF, reduction of the formyl group with NaBH4, mesylation of the resulting alcohol and subsequent reduction of the mesylate. The preparation of phthalide 135 was affected in quantitative yield on treatment of 134 with K2CO3 in dry MeOH. Selective ozonolysis of compound 135, followed by Jones oxidation and esterification afforded ester 136. Demethylation with BCl3 in DCM followed by hydrolysis of the ester function gave the mycophenolic acid (137). The mycophenolic acid was then converted to its sodium salt XVII (no conditions and yield available￡?.

MYCOPHENOLATE SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MYCOPHENOLATE SODIUM manufacturers

Sinoway Industrial co., ltd.

Product: Mycophenolate Sodium 37415-62-6
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: USP
Supply Ability: 20 tons
Release date: 2021-08-09

Shanghai Affida new material science and technology center

Product: Mycophenolate Sodium 37415-62-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 20 tons
Release date: 2024-03-14

shandong perfect biotechnology co.ltd

Product: mycophenolate sodium 37415-62-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 500kg
Release date: 2023-11-16

37415-62-6, MYCOPHENOLATE SODIUMRelated Search:

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MYCOPHENOLATE SODIUM

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Mycophenolate sodium CRS

Mycophenolate sodiumQ: What is Mycophenolate sodium Q: What is the CAS Number of Mycophenolate sodium Q: What is the storage condition of Mycophenolate sodium Q: What are the applications of Mycophenolate sodium

Mycophenolate Sodium (1448989)

Mycophenolic acid sodium

Mycophenolate Mofetil EP Impurity F Na salt

Mycophenol sodium

37415-62-6

C17H19NaO6

C17H19O6Na