2,2-Dimethylthiopropionamide
- Product Name
- 2,2-Dimethylthiopropionamide
- CAS No.
- 630-22-8
- Chemical Name
- 2,2-Dimethylthiopropionamide
- Synonyms
- NSC 381432;Thiopivalamide;Neopentanethioamide;Dalafenil Impurity 4;2,2-DIMETHYLTHIOPROPIOMIDE;2,2-Trimethylthioacetamide;2,2-DIMETHYLTHIOPROPIONAMIDE;2,2,2-Trimethylthioacetamide,;2,2,2-Dimethylthiopropionamide;Propanethioamide, 2,2-dimethyl-
- CBNumber
- CB61449866
- Molecular Formula
- C5H11NS
- Formula Weight
- 117.21
- MOL File
- 630-22-8.mol
2,2-Dimethylthiopropionamide Property
- Melting point:
- 117-119℃ (ethyl acetate hexane )
- Boiling point:
- 162.1±23.0℃ (760 Torr)
- Density
- 0.978±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 51.9±22.6℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Ethyl Acetate
- form
- Solid
- pka
- 13.33±0.29(Predicted)
- color
- White
- Water Solubility
- Soluble in water (10 g/L) (25°C).
- InChI
- InChI=1S/C5H11NS/c1-5(2,3)4(6)7/h1-3H3,(H2,6,7)
- InChIKey
- FJZJUSOFGBXHCV-UHFFFAOYSA-N
- SMILES
- C(N)(=S)C(C)(C)C
Safety
- HS Code
- 2930909899
N-Bromosuccinimide Price
- Product number
- T796135
- Product name
- 2,2-Dimethylthiopropionamide
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 9562AB
- Product name
- 2,2,2-Trimethylthioacetamide
- Packaging
- 1g
- Price
- $38
- Updated
- 2021/12/16
- Product number
- J99033
- Product name
- 2,2,2-Trimethylthioacetamide
- Packaging
- 5g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- FD36176
- Product name
- 2,2-Dimethylthiopropionamide
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- 7169-1-00
- Product name
- 2,2-Dimethylpropanethioamide
- Purity
- 95%
- Packaging
- 1g
- Price
- $112
- Updated
- 2021/12/16
2,2-Dimethylthiopropionamide Chemical Properties,Usage,Production
Uses
2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).
Synthesis
To a round bottom flask (250 mL) was added trimethyl amine (5.0 g, 0.049 mol) and Lawesson's reagent (8.0g, 0.020 mol), dissolved in THF (100 mL), nitrogen, 80° C oil. The reaction bath for 4 hours. TLC monitors the reaction progress. After completion of the reaction, the solvent was removed by rotary evaporation; the residue was purified by silica gel column chromatography (petroleum ether: 1: ethyl acetate = 10) to give a white solid 2,2-Dimethylthiopropionamide (3.7 g, 65percent yield).
References
[1] Chemistry - A European Journal, 2013, vol. 19, # 29, p. 9655 - 9662
[2] Phosphorus and Sulfur and the Related Elements, 1986, vol. 26, p. 169 - 184
[3] Patent: CN103936728, 2016, B. Location in patent: Paragraph 0211; 0213; 0214; 0215
[4] Canadian Journal of Chemistry, 1977, vol. 55, p. 2331 - 2335
[5] Journal of the Chemical Society [Section] C: Organic, 1966, p. 686 - 691
2,2-Dimethylthiopropionamide Preparation Products And Raw materials
Raw materials
Preparation Products
2,2-Dimethylthiopropionamide Suppliers
- Tel
- 0531-68653689 13127106931
- 1720760574@qq.com
- Country
- China
- ProdList
- 111
- Advantage
- 58
- Tel
- 15315319889
- wannaswsw@163.com
- Country
- China
- ProdList
- 299
- Advantage
- 58
- Tel
- +86-21 5768 0965 +86-13916707528
- Fax
- (21) 5768 0922
- yusu@enkibiopharma.com
- Country
- China
- ProdList
- 45
- Advantage
- 55
- Tel
- 15861782979
- 32860091@qq.com
- Country
- China
- ProdList
- 297
- Advantage
- 58
- Tel
- 0518-85415818; 18000194506
- 2818153737@qq.com
- Country
- China
- ProdList
- 48
- Advantage
- 58
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 48457
- Advantage
- 58
- Tel
- 18668921571 18668921571;
- liujnlz@126.com
- Country
- China
- ProdList
- 22
- Advantage
- 58
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 18515581800 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 9400
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
View Lastest Price from 2,2-Dimethylthiopropionamide manufacturers
- Product
- 2,2,2-Dimethylthiopropionamide 630-22-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99% HPLC
- Supply Ability
- 1KG 100KG 1MT
- Release date
- 2025-05-07
- Product
- 2,2-Dimethylthiopropionamide 630-22-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%min
- Supply Ability
- 10mt
- Release date
- 2024-07-29
- Product
- 2,2-DIMETHYLTHIOPROPIONAMIDE 630-22-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-10