ChemicalBook > CAS DataBase List > 2,2-Dimethylthiopropionamide

2,2-Dimethylthiopropionamide

Product Name
2,2-Dimethylthiopropionamide
CAS No.
630-22-8
Chemical Name
2,2-Dimethylthiopropionamide
Synonyms
NSC 381432;Thiopivalamide;Neopentanethioamide;2,2-DIMETHYLTHIOPROPIOMIDE;2,2-Trimethylthioacetamide;2,2-DIMETHYLTHIOPROPIONAMIDE;2,2,2-Trimethylthioacetamide,;2,2,2-Dimethylthiopropionamide;Propanethioamide, 2,2-dimethyl-
CBNumber
CB61449866
Molecular Formula
C5H11NS
Formula Weight
117.21
MOL File
630-22-8.mol
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2,2-Dimethylthiopropionamide Property

Melting point:
117-119℃ (ethyl acetate hexane )
Boiling point:
162.1±23.0℃ (760 Torr)
Density 
0.978±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:
51.9±22.6℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform, Ethyl Acetate
form 
Solid
pka
13.33±0.29(Predicted)
color 
White
Water Solubility 
Soluble in water (10 g/L) (25°C).
InChI
InChI=1S/C5H11NS/c1-5(2,3)4(6)7/h1-3H3,(H2,6,7)
InChIKey
FJZJUSOFGBXHCV-UHFFFAOYSA-N
SMILES
C(N)(=S)C(C)(C)C
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Safety

HS Code 
2930909899
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H32092
Product name
2,2,2-Trimethylthioacetamide, 97%
Packaging
1g
Price
$53.65
Updated
2024/03/01
Alfa Aesar
Product number
H32092
Product name
2,2,2-Trimethylthioacetamide, 97%
Packaging
10g
Price
$315.65
Updated
2024/03/01
TRC
Product number
T796135
Product name
2,2-Dimethylthiopropionamide
Packaging
1g
Price
$50
Updated
2021/12/16
AK Scientific
Product number
9562AB
Product name
2,2,2-Trimethylthioacetamide
Packaging
1g
Price
$38
Updated
2021/12/16
AK Scientific
Product number
J99033
Product name
2,2,2-Trimethylthioacetamide
Packaging
5g
Price
$88
Updated
2021/12/16
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2,2-Dimethylthiopropionamide Chemical Properties,Usage,Production

Uses

2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).

Synthesis

To a round bottom flask (250 mL) was added trimethyl amine (5.0 g, 0.049 mol) and Lawesson's reagent (8.0g, 0.020 mol), dissolved in THF (100 mL), nitrogen, 80° C oil. The reaction bath for 4 hours. TLC monitors the reaction progress. After completion of the reaction, the solvent was removed by rotary evaporation; the residue was purified by silica gel column chromatography (petroleum ether: 1: ethyl acetate = 10) to give a white solid 2,2-Dimethylthiopropionamide (3.7 g, 65percent yield).

2,2-Dimethylthiopropionamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2-Dimethylthiopropionamide Suppliers

China 137 India 4 United Kingdom 3 United States 5 Global 149
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View Lastest Price from 2,2-Dimethylthiopropionamide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2,2-Dimethylthiopropionamide 630-22-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%min
Supply Ability
10mt
Release date
2024-07-29
Enki Biopharmaceuticals (Shanghai) Limited
Product
2,2-Dimethylpropanethioamide 630-22-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.0%
Supply Ability
20000
Release date
2023-12-18
Zison Pharmaceutical (Shandong) Co., Ltd.
Product
2,2-Dimethylthiopropionamide 630-22-8
Price
US $0.00/kg
Min. Order
0.1kg
Purity
99.9%
Supply Ability
40-80kgs
Release date
2024-05-24

630-22-8, 2,2-DimethylthiopropionamideRelated Search:

2,2-Dimethylthiopropionamide 2,2-DIMETHYLPROPANETHIOHYDRAZIDE 1-(aminocarbonothioyl)cyclopentanecarboxylic acid AKOS BBS-00006261

  • 2,2,2-Dimethylthiopropionamide
  • 2,2-DIMETHYLTHIOPROPIONAMIDE
  • 2,2,2-Trimethylthioacetamide,
  • Neopentanethioamide
  • NSC 381432
  • Thiopivalamide
  • 2,2-DIMETHYLTHIOPROPIOMIDE
  • Propanethioamide, 2,2-dimethyl-
  • 2,2-Trimethylthioacetamide
  • 630-22-8