2,2-Dimethylthiopropionamide

Product Name: 2,2-Dimethylthiopropionamide
CAS No.: 630-22-8
Chemical Name: 2,2-Dimethylthiopropionamide
Synonyms: NSC 381432;Thiopivalamide;Neopentanethioamide;2,2-DIMETHYLTHIOPROPIOMIDE;2,2-Trimethylthioacetamide;2,2-DIMETHYLTHIOPROPIONAMIDE;2,2,2-Trimethylthioacetamide,;2,2,2-Dimethylthiopropionamide;Propanethioamide, 2,2-dimethyl-
CBNumber: CB61449866
Molecular Formula: C5H11NS
Formula Weight: 117.21
MOL File: 630-22-8.mol

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2,2-Dimethylthiopropionamide Property

Melting point:: 117-119℃ (ethyl acetate hexane )
Boiling point:: 162.1±23.0℃ (760 Torr)
Density: 0.978±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 51.9±22.6℃
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Ethyl Acetate
form: Solid
pka: 13.33±0.29(Predicted)
color: White
Water Solubility: Soluble in water (10 g/L) (25°C).
InChI: InChI=1S/C5H11NS/c1-5(2,3)4(6)7/h1-3H3,(H2,6,7)
InChIKey: FJZJUSOFGBXHCV-UHFFFAOYSA-N
SMILES: C(N)(=S)C(C)(C)C

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Safety

HS Code: 2930909899

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: H32092
Product name: 2,2,2-Trimethylthioacetamide, 97%
Packaging: 1g
Price: $53.65
Updated: 2024/03/01

Alfa Aesar

Product number: H32092
Product name: 2,2,2-Trimethylthioacetamide, 97%
Packaging: 10g
Price: $315.65
Updated: 2024/03/01

TRC

Product number: T796135
Product name: 2,2-Dimethylthiopropionamide
Packaging: 1g
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: 9562AB
Product name: 2,2,2-Trimethylthioacetamide
Packaging: 1g
Price: $38
Updated: 2021/12/16

AK Scientific

Product number: J99033
Product name: 2,2,2-Trimethylthioacetamide
Packaging: 5g
Price: $88
Updated: 2021/12/16

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2,2-Dimethylthiopropionamide Chemical Properties,Usage,Production

Uses

2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).

Synthesis

To a round bottom flask (250 mL) was added trimethyl amine (5.0 g, 0.049 mol) and Lawesson's reagent (8.0g, 0.020 mol), dissolved in THF (100 mL), nitrogen, 80° C oil. The reaction bath for 4 hours. TLC monitors the reaction progress. After completion of the reaction, the solvent was removed by rotary evaporation; the residue was purified by silica gel column chromatography (petroleum ether: 1: ethyl acetate = 10) to give a white solid 2,2-Dimethylthiopropionamide (3.7 g, 65percent yield).

2,2-Dimethylthiopropionamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2-Dimethylthiopropionamide Suppliers

China 137 India 4 United Kingdom 3 United States 5 Global 149

Beihua Chemical (Shandong) Co., LTD

Tel: 0531-68653689 13127106931
Email: 1720760574@qq.com
Country: China
ProdList: 53
Advantage: 58

Shanghai Lingfu Pharmaceutical Research Co. LTD

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Shandong Winner Biotechnology Co., Ltd.

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Enki Biopharmaceuticals(Shanghai) Limited

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Country: China
ProdList: 44
Advantage: 55

Shanghai Hope Chem Co., Ltd.，

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Lianyungang Xuanyuan Chemical Co., Ltd

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Shanghai Aladdin Biochemical Technology Co.,Ltd.

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JINAN RUIFENG PHARMACEUTICAL TECHNOLOGY CO.,LTD

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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
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View Lastest Price from 2,2-Dimethylthiopropionamide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2,2-Dimethylthiopropionamide 630-22-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%min
Supply Ability: 10mt
Release date: 2024-07-29

Enki Biopharmaceuticals (Shanghai) Limited

Product: 2,2-Dimethylpropanethioamide 630-22-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 20000
Release date: 2023-12-18

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: 2,2-Dimethylthiopropionamide 630-22-8
Price: US $0.00/kg
Min. Order: 0.1kg
Purity: 99.9%
Supply Ability: 40-80kgs
Release date: 2024-05-24

630-22-8, 2,2-DimethylthiopropionamideRelated Search:

2,2-Dimethylthiopropionamide 2,2-DIMETHYLPROPANETHIOHYDRAZIDE 1-(aminocarbonothioyl)cyclopentanecarboxylic acid AKOS BBS-00006261

2,2,2-Dimethylthiopropionamide

2,2-DIMETHYLTHIOPROPIONAMIDE

2,2,2-Trimethylthioacetamide,

Neopentanethioamide

NSC 381432

Thiopivalamide

2,2-DIMETHYLTHIOPROPIOMIDE

Propanethioamide, 2,2-dimethyl-

2,2-Trimethylthioacetamide

630-22-8