2-methoxy-4-methyl-benzaldehyde
- Product Name
- 2-methoxy-4-methyl-benzaldehyde
- CAS No.
- 57415-35-7
- Chemical Name
- 2-methoxy-4-methyl-benzaldehyde
- Synonyms
- 4-Methyl-6-methoxybenzaldehyde;2-methoxy-4-methyl-benzaldehyde;Benzaldehyde, 2-methoxy-4-methyl-;2-methoxy-4-methylbenzaldehyde(SALTDATA: FREE)
- CBNumber
- CB61458781
- Molecular Formula
- C9H10O2
- Formula Weight
- 150.17
- MOL File
- 57415-35-7.mol
2-methoxy-4-methyl-benzaldehyde Property
- Melting point:
- 40-43 ºC
- Boiling point:
- 258 ºC
- Density
- 1.062
- Flash point:
- 114 ºC
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to brown Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M263445
- Product name
- 2-Methoxy-4-methylbenzaldehyde
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 033831
- Product name
- 2-Methoxy-4-methyl-benzaldehyde
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- Z0701
- Product name
- 2-Methoxy-4-methylbenzaldehyde
- Packaging
- 5g
- Price
- $224
- Updated
- 2021/12/16
- Product number
- 2715-1-37
- Product name
- 2-Methoxy-4-methylbenzaldehyde
- Packaging
- 1g
- Price
- $311
- Updated
- 2021/12/16
- Product number
- Z0701
- Product name
- 2-Methoxy-4-methylbenzaldehyde
- Packaging
- 25g
- Price
- $691
- Updated
- 2021/12/16
2-methoxy-4-methyl-benzaldehyde Chemical Properties,Usage,Production
Uses
2-Methoxy-4-methylbenzaldehyde acts as a reagent in the synthesis of [3,2-d]pyrimidine derivatives as week as in the synthesis of tachykinin NK2 receptor antagonists which may be used in the treatment of IBS.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 35, p. 734, 1992 DOI: 10.1021/jm00082a014
Synthesis
698-27-1
74-88-4
57415-35-7
GENERAL METHODS: Potassium carbonate (K2CO3, 35 mg, 0.25 mmol) was added to a solution of anhydrous N,N-dimethylformamide (DMF, 6.0 mL) of 2-hydroxy-4-methylbenzaldehyde (34 mg, 0.25 mmol) and the mixture was stirred at room temperature for 30 min. Subsequently, iodomethane (CH3I, 30 μL, 68 mg, 0.5 mmol) was added and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, distilled water was added to terminate the reaction and the aqueous phase was extracted three times with ethyl acetate (EtOAc). The organic phases were combined and dried over anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography.
References
[1] Beilstein Journal of Organic Chemistry, 2018, vol. 14, p. 734 - 746
[2] Synthesis (Germany), 2017, vol. 49, # 1,
2-methoxy-4-methyl-benzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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