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2-Hydroxy-5-phenylpyridine

Product Name
2-Hydroxy-5-phenylpyridine
CAS No.
76053-45-7
Chemical Name
2-Hydroxy-5-phenylpyridine
Synonyms
5-phenylpyridin-2-ol;5-phenylpyridin-2(1H)-one;5-Phenyl-1H-pyridin-2-one;2-Hydroxy-5-phenylpyridine;2(1H)-Pyridinone, 5-phenyl-
CBNumber
CB61471142
Molecular Formula
C11H9NO
Formula Weight
171.2
MOL File
76053-45-7.mol
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2-Hydroxy-5-phenylpyridine Property

Melting point:
128 °C
Boiling point:
394.7±35.0 °C(Predicted)
Density 
1.158±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
11.60±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0060511
Product name
5-Phenyl-1H-pyridin-2-one
Packaging
100mg
Price
$161
Updated
2021/12/16
ChemScene
Product number
CS-0060511
Product name
5-Phenyl-1H-pyridin-2-one
Packaging
250mg
Price
$268
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0385851
Product name
2-HYDROXY-5-PHENYLPYRIDINE
Purity
95.00%
Packaging
5MG
Price
$501.96
Updated
2021/12/16
ChemScene
Product number
CS-0060511
Product name
5-Phenyl-1H-pyridin-2-one
Packaging
1g
Price
$536
Updated
2021/12/16
AK Scientific
Product number
V7648
Product name
2-Hydroxy-5-phenylpyridine
Packaging
1g
Price
$566
Updated
2021/12/16
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2-Hydroxy-5-phenylpyridine Chemical Properties,Usage,Production

Synthesis

53698-47-8

76053-45-7

GENERAL METHOD: 2-methoxy-5-phenylpyridine (9.19 mmol) was combined with pyridine hydrochloride (10.55 g, 91.9 mmol) in a 100 mL round bottom flask and heated with continuous stirring for 20 minutes at 160°C in an oil bath. After completion of the reaction, the mixture was cooled to room temperature. Subsequently, saturated sodium chloride solution (40 mL) and deionized water (20 mL) were added for dilution. The precipitated white solid was collected by filtration and dissolved in ethyl acetate. The resulting solution was filtered through a short silica gel column and washed well with ethyl acetate until thin layer chromatography (TLC) detection showed complete conversion of the raw material to the product.

References

[1] Tetrahedron, 2014, vol. 70, # 45, p. 8624 - 8635
[2] Patent: US2009/318455, 2009, A1. Location in patent: Page/Page column 67; 83
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10584 - 10600

2-Hydroxy-5-phenylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxy-5-phenylpyridine Suppliers

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028-85114309 18982182443
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China
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Nanjing ShengSai Chemical Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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