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BRITANIN

Product Name
BRITANIN
CAS No.
33627-28-0
Chemical Name
BRITANIN
Synonyms
Britannin;ritannin;Inulicin A;UbcH5c inhibitor DHPO;Britannin, 10 mM in DMSO;6-O-Acetyl-4-O-deacetylinuchinenolide C;Inhibitor,inhibit,Autophagy,Britannin,Apoptosis;2α,6α-diacetoxy-4β-hydroxy-11(13)-pseudoguaien-12,8α-olide;(3aR,4S,4aS,5S,7S,7aS,8R,9aS)-5-Hydroxy-4a,8-dimethyl-3-methylene-2-oxododecahydroazuleno[6,5-b]furan-4,7-diyl diacetate;Azuleno[6,5-b]furan-2(3H)-one,4,7-bis(acetyloxy)decahydro-5-hydroxy-4a,8-dimethyl-3-methylene-,(3aR,4S,4aR,5S,7S,7aS,8R,9aS)-
CBNumber
CB61484540
Molecular Formula
C19H26O7
Formula Weight
366.41
MOL File
33627-28-0.mol
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BRITANIN Property

Melting point:
189-191 °C
Boiling point:
491.8±45.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
Soluble in DMSO
form 
Solid
pka
14.08±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FB153338
Product name
Britannin
Packaging
1mg
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB153338
Product name
Britannin
Packaging
2mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0022906
Product name
Britannin
Packaging
5mg
Price
$336
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB153338
Product name
Britannin
Packaging
5mg
Price
$450
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PXT0005146
Product name
BRITANIN
Purity
95.00%
Packaging
5MG
Price
$501.75
Updated
2021/12/16
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BRITANIN Chemical Properties,Usage,Production

Chemical Properties

White crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Inulin.

Uses

Britannin has effects in anti-inflammatory, antibacterial, antitussive and expectorant.

Biological Activity

Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone. It induces apoptosis and autophagy in liver cancer cells by activating AMPK regulated by ROS, and has anti-proliferative and anti-inflammatory activities.

in vivo

Britannin (20 mg/kg, i.p., once daily for 3 consecutive days) ameliorates lung injury and systemic infection in Lipopolysaccharides (LPS) (HY-D1056) -induced acute lung injury mouse model in an NLRP3-dependent manner[4]. Britannin (20 mg/kg, i.p., once every other day, for a total of 3 injections) relieves gouty arthritis in Monosodium urate (HY-B2130A) -induced gouty arthritis mouse model by inhibiting NLRP3 activation[4].

Animal Model:Monosodium urate (HY-B2130A) -induced gouty arthritis mouse model, Lipopolysaccharides (LPS) (HY-D1056) -induced acute lung injury mouse model[4]
Dosage:20 mg/kg
Administration:Intraperitoneal injection (i.p.), inject for three consecutive days (acute lung injury mouse model) or once every other day, for a total of 3 injections (Monosodium urate (HY-B2130A) -induced gouty arthritis mouse model)
Result:Significantly suppressed the changes in footpad joint size, alleviated the migration of inflammatory cells in Monosodium urate (HY-B2130A) -induced gouty arthritis mouse model and nhibited the secretion of IL-1β and the activation of Caspase-1, demonstrating that Britannin prevented gouty arthritis through anti-inflammatory effects.
Suppressed pulmonary edema, breakdown of the pneumatic blood barrier, and cell infiltration in lung tissues and pathological injury and inflammatory cell infiltration in lung tissues, were ameliorated by Britannin treatment.

IC 50

NLRP3: 3.630 μM (IC50)

BRITANIN Preparation Products And Raw materials

Raw materials

Preparation Products

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BRITANIN Suppliers

China 80 United Kingdom 2 United States 5 Global 87
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Shanghai Winherb Medical Technology Co., Ltd.
Tel
021-38218169 13341702378
Fax
QQ：190129269
Email
winherb@126.com
Country
China
ProdList
1245
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3988
Advantage
66
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
6905
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
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View Lastest Price from BRITANIN manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
BRITANIN 33627-28-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-14
Career Henan Chemical Co
Product
2α,6α-diacetoxy-4β-hydroxy-11(13)-pseudoguaien-12,8α-olide 33627-28-0
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

33627-28-0, BRITANINRelated Search:

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  • Britannin
  • 6-O-Acetyl-4-O-deacetylinuchinenolide C
  • 2α,6α-diacetoxy-4β-hydroxy-11(13)-pseudoguaien-12,8α-olide
  • Azuleno[6,5-b]furan-2(3H)-one,4,7-bis(acetyloxy)decahydro-5-hydroxy-4a,8-dimethyl-3-methylene-,(3aR,4S,4aR,5S,7S,7aS,8R,9aS)-
  • Azuleno[6,5-b]furan-2(3H)-one, 4,7-bis(acetyloxy)decahydro-5-hydroxy-4a,8-dimethyl-3-methylene-, (3aR,4S,4aS,5S,7S,7aS,8R,9aS)-
  • ritannin
  • Inhibitor,inhibit,Autophagy,Britannin,Apoptosis
  • Inulicin A
  • UbcH5c inhibitor DHPO
  • (3aR,4S,4aS,5S,7S,7aS,8R,9aS)-5-Hydroxy-4a,8-dimethyl-3-methylene-2-oxododecahydroazuleno[6,5-b]furan-4,7-diyl diacetate
  • Britannin, 10 mM in DMSO
  • 33627-28-0
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