5-METHYL-2-NITROBENZONITRILE
- Product Name
- 5-METHYL-2-NITROBENZONITRILE
- CAS No.
- 64113-86-6
- Chemical Name
- 5-METHYL-2-NITROBENZONITRILE
- Synonyms
- 6-nitro-m-tolunitrile;Benzonitrile,5-Methyl-2-nitro-;5-METHYL-2-NITROBENZONITRILE ISO 9001：2015 REACH;Cyclohepta[c]pyrazole-3-carboxylicacid,2,4,5,6,7,11-hexahydro-,ethylester
- CBNumber
- CB61484878
- Molecular Formula
- C8H6N2O2
- Formula Weight
- 162.15
- MOL File
- 64113-86-6.mol
5-METHYL-2-NITROBENZONITRILE Property
- Melting point:
- 92 °C
- Boiling point:
- 338.9±30.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to yellow Solid
Safety
- HS Code
- 2926907090
N-Bromosuccinimide Price
- Product number
- M341270
- Product name
- 5-Methyl-2-nitrobenzonitrile
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CHM0101468
- Product name
- 5-METHYL-2-NITROBENZONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $187.95
- Updated
- 2021/12/16
- Product number
- 4754-1-0D
- Product name
- 5-Methyl-2-nitrobenzonitrile
- Purity
- 95.0%
- Packaging
- 5G
- Price
- $109
- Updated
- 2021/12/16
- Product number
- 074354
- Product name
- 5-Methyl-2-nitrobenzonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $347
- Updated
- 2021/12/16
- Product number
- W7590
- Product name
- 5-Methyl-2-nitrobenzonitrile
- Packaging
- 25g
- Price
- $391
- Updated
- 2021/12/16
5-METHYL-2-NITROBENZONITRILE Chemical Properties,Usage,Production
Synthesis
4315-12-2
64113-86-6
Phosphorus trichloride (16.96 mL, 1.1 eq.) was slowly added to a solution of N,N-dimethylformamide (329.6 mL) of 5-methyl-2-nitrobenzamide (29.8 g, 0.165 mol) via syringe over a period of 20 minutes. The reaction mixture was stirred at 25 °C for 40 min, followed by heating to 100 °C and continued stirring for 15 min. Upon completion of the reaction, the mixture was slowly poured into ice (750 g) and the pH of the aqueous solution was adjusted to 9-10 with ammonia (75 mL).The aqueous layer was extracted with ethyl acetate (1000 mL, followed by 2 x 600 mL). The organic layers were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 2-nitro-5-methylbenzonitrile (25.7 g, 96% yield) as a yellow solid, which could be used in subsequent reactions without further purification. The purity of the product was confirmed by 1H NMR: 1H NMR (CDCl3) δ 2.54 (s, 3H, CH3), 7.59 (d, J = 8.4 Hz, 1H, Ar-H), 7.71 (s, 1H, Ar-H), 8.24 (d, J = 8.4 Hz, 1H, Ar-H).
References
[1] Patent: US2004/92739, 2004, A1. Location in patent: Page 4
[2] Patent: US2009/253719, 2009, A1. Location in patent: Page/Page column 19-20
[3] Tetrahedron, 1994, vol. 50, # 18, p. 5515 - 5525
[4] Medicinal Chemistry Research, 1999, vol. 9, # 3, p. 176 - 185
[5] Patent: US2010/260825, 2010, A1. Location in patent: Page/Page column 4
5-METHYL-2-NITROBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHYL-2-NITROBENZONITRILE manufacturers
- Product
- 6-nitro-m-tolunitrile 64113-86-6
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-13