2-Amino-5-Methyl-Benzonitrile
- Product Name
- 2-Amino-5-Methyl-Benzonitrile
- CAS No.
- 5925-93-9
- Chemical Name
- 2-Amino-5-Methyl-Benzonitrile
- Synonyms
- 6-Amino-m-tolunitrile;4-Amino-3-cyanotoluene;2-Cyano-4-methylaniline;2-amino-5-methylbenzenitrile;2-Amino-5-methylbenzonitrile;Benzonitrile, 2-amino-5-methyl-;2-Amino-5-methylbenzonitrile 97%;2-azanyl-5-methyl-benzenecarbonitrile;(5Z)-5-[(4-methoxyphenyl)methylidene]-2-phenyl-6-thiazolo[3,2-b][1,2,4]triazolone
- CBNumber
- CB9949812
- Molecular Formula
- C8H8N2
- Formula Weight
- 132.16
- MOL File
- 5925-93-9.mol
2-Amino-5-Methyl-Benzonitrile Property
- Melting point:
- 59-63 °C
- Boiling point:
- 152°C/15mmHg(lit.)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- soluble in Methanol
- form
- Solid
- pka
- 2.25±0.10(Predicted)
- color
- White to Brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 696331
- Product name
- 2-Amino-5-methylbenzonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $45.6
- Updated
- 2023/01/07
- Product number
- A2843
- Product name
- 2-Amino-5-methylbenzonitrile
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $90
- Updated
- 2025/07/31
- Product number
- A614698
- Product name
- 2-Amino-5-methylbenzonitrile
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A614698
- Product name
- 2-Amino-5-methylbenzonitrile
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FA33035
- Product name
- 2-Amino-5-methylbenzonitrile
- Packaging
- 5G
- Price
- $87.5
- Updated
- 2021/12/16
2-Amino-5-Methyl-Benzonitrile Chemical Properties,Usage,Production
Uses
2-Amino-5-methylbenzonitrile can be used in combination therapy to treat Mucopolysaccharidosis I.
Synthesis
64113-86-6
5925-93-9
5-Methyl-2-nitrobenzonitrile (1.92 g, 11.84 mmol) was added in batches to a mixed solution of concentrated hydrochloric acid (12 mL) and ethanol (EtOH, 12 mL) with SnCl2 (11.22 g, 59.2 mmol) in stirring. The temperature was controlled at 20-30 °C using an ice bath during the reaction. The reaction mixture was continued to be stirred at room temperature for 1 h. The reaction mixture was then poured into pre-cooled aqueous 6N NaOH solution (ca. 30 mL) and neutralized to pH 7. The product was extracted with ethyl acetate (EtOAc), followed by washing of the organic layer with brine, drying with anhydrous magnesium sulfate (MgSO4), and concentration to give the target product, 2-amino-5-methylbenzonitrile (1.56 g, 99% yield) as a yellowish brown solid. The structure of the product was analyzed by 1H NMR (400 MHz, DMSO-d6) δ 2.21 (s, 3H), 5.79 (bs, 2H), 6.68-6.71 (d, 1H), 7.10-7.13 (dd, 1H), 7.15 (s, 1H); 13C NMR (DMSO-d6) δ 20.13,93.99,116.12, 118.94,125.38,132.32,135.76,150.21; mass spectrum (MS) m/z 133 (MH+) confirmed.
References
[1] Patent: US2008/306053, 2008, A1. Location in patent: Page/Page column 60
[2] Tetrahedron, 1994, vol. 50, # 18, p. 5515 - 5525
[3] Patent: US2004/92739, 2004, A1. Location in patent: Page 4
[4] Journal of Heterocyclic Chemistry, 1987, vol. 24, # 2, p. 345 - 349
[5] Chemische Berichte, 1905, vol. 38, p. 3555
2-Amino-5-Methyl-Benzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-5-Methyl-Benzonitrile manufacturers
- Product
- 2-Amino-5-Methyl-Benzonitrile 5925-93-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12