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2-Amino-5-Methyl-Benzonitrile

Product Name
2-Amino-5-Methyl-Benzonitrile
CAS No.
5925-93-9
Chemical Name
2-Amino-5-Methyl-Benzonitrile
Synonyms
6-Amino-m-tolunitrile;4-Amino-3-cyanotoluene;2-Cyano-4-methylaniline;2-amino-5-methylbenzenitrile;2-Amino-5-methylbenzonitrile;Benzonitrile, 2-amino-5-methyl-;2-Amino-5-methylbenzonitrile 97%;2-azanyl-5-methyl-benzenecarbonitrile;(5Z)-5-[(4-methoxyphenyl)methylidene]-2-phenyl-6-thiazolo[3,2-b][1,2,4]triazolone
CBNumber
CB9949812
Molecular Formula
C8H8N2
Formula Weight
132.16
MOL File
5925-93-9.mol
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2-Amino-5-Methyl-Benzonitrile Property

Melting point:
59-63 °C
Boiling point:
152°C/15mmHg(lit.)
Density 
1.10±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
Solid
pka
2.25±0.10(Predicted)
color 
White to Brown
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
RIDADR 
UN 3335
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
696331
Product name
2-Amino-5-methylbenzonitrile
Purity
97%
Packaging
1g
Price
$45.6
Updated
2023/01/07
TCI Chemical
Product number
A2843
Product name
2-Amino-5-methylbenzonitrile
Purity
>97.0%(GC)
Packaging
1g
Price
$90
Updated
2025/07/31
TRC
Product number
A614698
Product name
2-Amino-5-methylbenzonitrile
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
A614698
Product name
2-Amino-5-methylbenzonitrile
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA33035
Product name
2-Amino-5-methylbenzonitrile
Packaging
5G
Price
$87.5
Updated
2021/12/16
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2-Amino-5-Methyl-Benzonitrile Chemical Properties,Usage,Production

Uses

2-Amino-5-methylbenzonitrile can be used in combination therapy to treat Mucopolysaccharidosis I.

Synthesis

64113-86-6

5925-93-9

5-Methyl-2-nitrobenzonitrile (1.92 g, 11.84 mmol) was added in batches to a mixed solution of concentrated hydrochloric acid (12 mL) and ethanol (EtOH, 12 mL) with SnCl2 (11.22 g, 59.2 mmol) in stirring. The temperature was controlled at 20-30 °C using an ice bath during the reaction. The reaction mixture was continued to be stirred at room temperature for 1 h. The reaction mixture was then poured into pre-cooled aqueous 6N NaOH solution (ca. 30 mL) and neutralized to pH 7. The product was extracted with ethyl acetate (EtOAc), followed by washing of the organic layer with brine, drying with anhydrous magnesium sulfate (MgSO4), and concentration to give the target product, 2-amino-5-methylbenzonitrile (1.56 g, 99% yield) as a yellowish brown solid. The structure of the product was analyzed by 1H NMR (400 MHz, DMSO-d6) δ 2.21 (s, 3H), 5.79 (bs, 2H), 6.68-6.71 (d, 1H), 7.10-7.13 (dd, 1H), 7.15 (s, 1H); 13C NMR (DMSO-d6) δ 20.13,93.99,116.12, 118.94,125.38,132.32,135.76,150.21; mass spectrum (MS) m/z 133 (MH+) confirmed.

References

[1] Patent: US2008/306053, 2008, A1. Location in patent: Page/Page column 60
[2] Tetrahedron, 1994, vol. 50, # 18, p. 5515 - 5525
[3] Patent: US2004/92739, 2004, A1. Location in patent: Page 4
[4] Journal of Heterocyclic Chemistry, 1987, vol. 24, # 2, p. 345 - 349
[5] Chemische Berichte, 1905, vol. 38, p. 3555

2-Amino-5-Methyl-Benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-Methyl-Benzonitrile Suppliers

Americas 1 China 110 Europe 1 India 15 Japan 1 Switzerland 3 United Kingdom 3 United States 13 Global 147
SIGMA-RBI
Tel
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Switzerland
ProdList
6896
Advantage
91
Matrix Fine Chemicals GmbH
Tel
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Fax
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Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
58
Achemica
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Email
contact@achemica.com
Country
Switzerland
ProdList
6155
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View Lastest Price from 2-Amino-5-Methyl-Benzonitrile manufacturers

Career Henan Chemical Co
Product
2-Amino-5-Methyl-Benzonitrile 5925-93-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-12

5925-93-9, 2-Amino-5-Methyl-BenzonitrileRelated Search:

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  • 4-Amino-3-cyanotoluene
  • 2-Amino-5-methylbenzonitrile
  • 2-azanyl-5-methyl-benzenecarbonitrile
  • Benzonitrile, 2-amino-5-methyl-
  • 2-Amino-5-methylbenzonitrile 97%
  • (5Z)-5-[(4-methoxyphenyl)methylidene]-2-phenyl-6-thiazolo[3,2-b][1,2,4]triazolone
  • 2-Cyano-4-methylaniline
  • 6-Amino-m-tolunitrile
  • 2-amino-5-methylbenzenitrile
  • 5925-93-9
  • Building Blocks
  • C8 to C9
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
  • C8 to C9
  • Cyanides/Nitriles
  • Nitrogen Compounds
  • Aromatic