4-Amino-3-methylbenzonitrile

Uses

Product Name: 4-Amino-3-methylbenzonitrile
CAS No.: 78881-21-7
Chemical Name: 4-Amino-3-methylbenzonitrile
Synonyms: 4-cyano-o-toluidine;4-amino-m-tolunitrile;2-Amino-5-cyanotoluene;4-cyano-2-methylaniline;2-Methyl-4-Cyanoaniline;3-Methyl-4-Aminobenzonitrile;4-AMINO-3-METHYLBENZONITRILE;Benzonitrile, 4-amino-3-methyl-;4-Amino-3-methylbenzonitrile >4-AMINO-3-METHYLBENZONITRILE, 98+%
CBNumber: CB1327685
Molecular Formula: C8H8N2
Formula Weight: 132.16
MOL File: 78881-21-7.mol

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4-Amino-3-methylbenzonitrile Property

Melting point:: 93-94°C
Boiling point:: 304.5±30.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 1.58±0.10(Predicted)
color: White to Gray to Brown
BRN: 3235728
InChIKey: MBZDCUMFFPWLTJ-UHFFFAOYSA-N
CAS DataBase Reference: 78881-21-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-43-20/21-36/37/38
Safety Statements: 22-36/37/39-36/37-26-9
RIDADR: 3276
HazardClass: 6.1
PackingGroup: III
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS001194
Product name: 4-Amino-3-methylbenzonitrile
Purity: AldrichCPR
Packaging: 5MG
Price: $73.1
Updated: 2025/07/31

TCI Chemical

Product number: A2107
Product name: 4-Amino-3-methylbenzonitrile
Purity: >97.0%(GC)
Packaging: 1g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: A2107
Product name: 4-Amino-3-methylbenzonitrile
Purity: >97.0%(GC)
Packaging: 5g
Price: $138
Updated: 2025/07/31

Apolloscientific

Product number: OR2931
Product name: 4-Amino-3-methylbenzonitrile
Packaging: 5g
Price: $101
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3737-1-Y3
Product name: 4-Amino-3-methylbenzonitrile
Packaging: 5G
Price: $111
Updated: 2021/12/16

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4-Amino-3-methylbenzonitrile Chemical Properties,Usage,Production

Uses

4-Amino-3-methylbenzonitrile is a useful research chemical used in organic synthesis and other chemical processes.

Chemical Properties

Light yellow powder

Synthesis

96784-54-2

78881-21-7

General procedure for the synthesis of 4-amino-3-methylbenzonitrile from 3-methyl-4-nitrobenzonitrile: 9.89 g (61 mmol, 1 equiv.) of 3-methyl-4-nitrobenzonitrile was added to a stirred 100 mL tetrahydrofuran (THF) solution at room temperature. Subsequently, 1 g of 10% palladium carbon catalyst was added. Next, 25 mL of methanol was added. The reaction system was placed in a hydrogenation unit and the reaction was carried out at a hydrogen pressure of 50 psi. When hydrogen consumption was no longer observed, the reaction was stopped and filtered through diatomaceous earth to remove the catalyst. The product was purified by column chromatography using a 1:1 mixture of hexane and dichloromethane as the mobile phase. 7.5 g of 4-amino-3-methylbenzonitrile in beige powder form was finally obtained in 93% yield. The 1H-NMR (DMSO-d6) data of the product were as follows: δ 2.27 (3H, s), 6.06 (2H, s), 6.41 (1H, d), 6.46 (1H, s), 7.30 (1H, d).

References

[1] Journal of Medicinal Chemistry, 1999, vol. 42, # 18, p. 3572 - 3587
[2] Patent: US2017/44373, 2017, A1. Location in patent: Paragraph 0227; 0228
[3] Patent: US6353006, 2002, B1. Location in patent: Page column 23
[4] Patent: US2005/54655, 2005, A1. Location in patent: Page/Page column 15
[5] Patent: US2004/44203, 2004, A1. Location in patent: Page 27

4-Amino-3-methylbenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-3-methylbenzonitrile Suppliers

Americas 1 Belgium 1 Canada 1 China 136 Europe 2 France 1 Germany 6 India 13 Japan 1 Switzerland 1 United Kingdom 15 United States 32 Global 210

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View Lastest Price from 4-Amino-3-methylbenzonitrile manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Amino-3-methylbenzonitrile 78881-21-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-04

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Amino-3-methylbenzonitrile 78881-21-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 4-Amino-3-methylbenzonitrile 78881-21-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-12

78881-21-7, 4-Amino-3-methylbenzonitrileRelated Search:

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4-AMINO-3-METHYLBENZONITRILE

4-Amino-m-tolunitrile~4-Cyano-o-toluidine

3-Methyl-4-Aminobenzonitrile

2-Methyl-4-Cyanoaniline

Benzonitrile, 4-amino-3-methyl- (9CI)

4-amino-m-tolunitrile

4-cyano-o-toluidine

4-cyano-2-methylaniline

4-AMINO-3-METHYLBENZONITRILE, 98+%

2-Amino-5-cyanotoluene

4-Cyano-o-toluidine 4-Cyano-2-methylaniline 2-Amino-5-cyanotoluene

Benzonitrile, 4-amino-3-methyl-

4-Amino-3-methylbenzonitrile &gt

78881-21-7

pharmacetical

NITRILE

Aromatic Nitriles