2-Amino-5-cyanobenzotrifluoride

Product Name: 2-Amino-5-cyanobenzotrifluoride
CAS No.: 327-74-2
Chemical Name: 2-Amino-5-cyanobenzotrifluoride
Synonyms: 4-Amino-3-(trifL;BUTTPARK 87\01-75;3-TRILFUOROMETHYL-4-AMI;Bicalutamide Impurity 4;2-Amino-5-cyanobenzotr...;2-AMINO-5-CYANOBENZOTRIFLUORIDE;3-TrifMethyl-4-aMinobenzonitrile;4-Cyano-2-(trifluoromethyl)aniline;2-Amino-5-cyanobenzotrifluoride99%;2-Amino-5-cyanobenzotrifluoride 99%
CBNumber: CB5713507
Molecular Formula: C8H5F3N2
Formula Weight: 186.13
MOL File: 327-74-2.mol

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2-Amino-5-cyanobenzotrifluoride Property

Melting point:: 60-63°C
Boiling point:: 100°C 0,1mm
Density: 1.37±0.1 g/cm3(Predicted)
Flash point:: 100°C/0.1mm
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: -1.41±0.10(Predicted)
color: White to Light Beige
BRN: 2970379
InChI: InChI=1S/C8H5F3N2/c9-8(10,11)6-3-5(4-12)1-2-7(6)13/h1-3H,13H2
InChIKey: MWLZJOBGDXBMBP-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=C(N)C(C(F)(F)F)=C1
CAS DataBase Reference: 327-74-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 23/24/25-36/38
Safety Statements: 26-36/37/39-45
RIDADR: 3439
Hazard Note: Toxic/Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2644
Product name: 4-Amino-3-(trifluoromethyl)benzonitrile
Purity: >98.0%(GC)
Packaging: 1g
Price: $98
Updated: 2025/07/31

TCI Chemical

Product number: A2644
Product name: 4-Amino-3-(trifluoromethyl)benzonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $326
Updated: 2025/07/31

TRC

Product number: A603815
Product name: 2-Amino-5-cyanobenzotrifluoride
Packaging: 5g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: F611
Product name: 4-Amino-3-trifluoromethylbenzonitrile
Packaging: 25g
Price: $94
Updated: 2021/12/16

Matrix Scientific

Product number: 011083
Product name: 2-Amino-5-cyanobenzotrifluoride
Purity: 98%
Packaging: 5g
Price: $14
Updated: 2021/12/16

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2-Amino-5-cyanobenzotrifluoride Chemical Properties,Usage,Production

Uses

2-Amino-5-cyanobenzotrifluoride is used in the design and synthesis of 4-phenylpyrrole derivatives as androgen receptor antagonists which show efficacy against prostate cancer cells.

Synthesis

887144-94-7

873-74-5

327-74-2

The general steps for synthesizing 2-trifluoromethyl-4-cyanobenzenamine from 1-(trifluoromethyl)-1,2-phenyliodono-3(1H)-one and p-aminobenzonitrile are as follows: in this embodiment of the method of preparing trifluoromethyl aromatic amine, p-cyanobenzenamine was selected as the aromatic amine, and the reaction time was 12 hours, and the rest of the reaction conditions and the post-processing steps were kept the same as in Example 28. The specific reaction process parameters were as follows: 1-(trifluoromethyl)-1,2-phenyliodono-3(1H)-one (0.5 mmol, 1.0 eq.), p-aminobenzonitrile (1.5 mmol, 3.0 eq.), nickel hydroxide (10 mol%), and potassium carbonate (1.5 mmol, 3.0 eq.) were dissolved in DMSO (2 mL), and the reaction was carried out for 2 hr at 35 °C. The subsequent reaction and post-treatment procedures were carried out with reference to Example 1.

References

[1] Organic Letters, 2018, vol. 20, # 13, p. 3732 - 3735
[2] Patent: CN108503552, 2018, A. Location in patent: Paragraph 0126-0130
[3] Organic Letters, 2014, vol. 16, # 6, p. 1768 - 1771

2-Amino-5-cyanobenzotrifluoride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-cyanobenzotrifluoride Suppliers

Americas 1 Canada 1 China 178 Europe 4 Germany 6 India 11 Italy 1 Japan 1 Ukraine 2 United Kingdom 11 United States 36 Global 252

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View Lastest Price from 2-Amino-5-cyanobenzotrifluoride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Amino-5-cyanobenzotrifluoride 327-74-2
Price: US $0.00-0.00/KG
Min. Order: 50mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-08

Career Henan Chemical Co

Product: 2-Amino-5-cyanobenzotrifluoride 327-74-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-06-27

327-74-2, 2-Amino-5-cyanobenzotrifluorideRelated Search:

2-Aminobenzotrifluoride Benzonitrile 4-Aminobenzonitrile 4-Amino-2-(trifluoromethyl)benzonitrile 2-Amino-5-trifluoromethylbenzonitrile 2-Bromo-4-cyano-6-(trifluoromethyl)aniline 2-Amino-5-cyanobenzotrifluoride 4-Cyano-2-(trifluoromethyl)phenylhydrazine 4-Cyano-2-(trifluoromethyl)phenylisothiocyanate 3,5-BIS(TRIFLUOROMETHYL)-4-AMINOBENZONITRILE 4-NITRO-3-(TRIFLUOROMETHYL)BENZONITRILE 4-CYANO-2-(TRIFLUOROMETHYL)ACETANILIDE 2-Bromo-4-cyano-6-(trifluoromethyl)-phenylisothiocyanate 2-AMINO-3-CHLORO-5-CYANOBENZOTRIFLUORIDE

BUTTPARK 87\01-75

2-AMINO-5-CYANOBENZOTRIFLUORIDE

3-TRIFLUOROMETHYL-4-AMINOBENZONITRILE

4-AMINO-3-TRIFLUOROMETHYLBENZONITRILE

4-Cyano-2-(trifluoromethyl)aniline

2-Amino-5-cyanobenzotrifluoride 99%

2-Amino-5-cyanobenzotrifluoride99%

3-TRILFUOROMETHYL-4-AMINOBENZONITRILE

3-TRILFUOROMETHYL-4-AMI

3-TrifMethyl-4-aMinobenzonitrile

4-Amino-3-(trifluoromethyl)benzonitrile 99%

4-Cyano-2-(trifluoromethyl)aniline, 2-Amino-5-cyanobenzotrifluoride

4- aMino-3-(threetrifluoroMethyl)benzonitrile

2-amino-5-cyano-trifluoromethylbenzene

4-Amino-3-(trifluoromethyl)benzonitrile &gt

4-Amino-3-(trifL

Bicalutamide Impurity 4

Benzonitrile, 4-amino-3-(trifluoromethyl)-

2-Amino-5-cyanobenzotr...

327-74-2

17528-23-6

C8H5F3N2

C8H5N2F3

Fluorine series

Nitrile

Benzotrifluoride Series

Trifluoromethylbenzene serise