4-Amino-3-methylbenzonitrile
Uses- Product Name
- 4-Amino-3-methylbenzonitrile
- CAS No.
- 78881-21-7
- Chemical Name
- 4-Amino-3-methylbenzonitrile
- Synonyms
- 4-cyano-o-toluidine;4-amino-m-tolunitrile;2-Amino-5-cyanotoluene;4-cyano-2-methylaniline;2-Methyl-4-Cyanoaniline;3-Methyl-4-Aminobenzonitrile;4-AMINO-3-METHYLBENZONITRILE;Benzonitrile, 4-amino-3-methyl-;4-Amino-3-methylbenzonitrile >4-AMINO-3-METHYLBENZONITRILE, 98+%
- CBNumber
- CB1327685
- Molecular Formula
- C8H8N2
- Formula Weight
- 132.16
- MOL File
- 78881-21-7.mol
4-Amino-3-methylbenzonitrile Property
- Melting point:
- 93-94°C
- Boiling point:
- 304.5±30.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 1.58±0.10(Predicted)
- color
- White to Gray to Brown
- BRN
- 3235728
- InChIKey
- MBZDCUMFFPWLTJ-UHFFFAOYSA-N
- CAS DataBase Reference
- 78881-21-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-43-20/21-36/37/38
- Safety Statements
- 22-36/37/39-36/37-26-9
- RIDADR
- 3276
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CDS001194
- Product name
- 4-Amino-3-methylbenzonitrile
- Purity
- AldrichCPR
- Packaging
- 5MG
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- A2107
- Product name
- 4-Amino-3-methylbenzonitrile
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $46
- Updated
- 2025/07/31
- Product number
- A2107
- Product name
- 4-Amino-3-methylbenzonitrile
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $138
- Updated
- 2025/07/31
- Product number
- OR2931
- Product name
- 4-Amino-3-methylbenzonitrile
- Packaging
- 5g
- Price
- $101
- Updated
- 2021/12/16
- Product number
- 3737-1-Y3
- Product name
- 4-Amino-3-methylbenzonitrile
- Packaging
- 5G
- Price
- $111
- Updated
- 2021/12/16
4-Amino-3-methylbenzonitrile Chemical Properties,Usage,Production
Uses
4-Amino-3-methylbenzonitrile is a useful research chemical used in organic synthesis and other chemical processes.
Chemical Properties
Light yellow powder
Synthesis
96784-54-2
78881-21-7
General procedure for the synthesis of 4-amino-3-methylbenzonitrile from 3-methyl-4-nitrobenzonitrile: 9.89 g (61 mmol, 1 equiv.) of 3-methyl-4-nitrobenzonitrile was added to a stirred 100 mL tetrahydrofuran (THF) solution at room temperature. Subsequently, 1 g of 10% palladium carbon catalyst was added. Next, 25 mL of methanol was added. The reaction system was placed in a hydrogenation unit and the reaction was carried out at a hydrogen pressure of 50 psi. When hydrogen consumption was no longer observed, the reaction was stopped and filtered through diatomaceous earth to remove the catalyst. The product was purified by column chromatography using a 1:1 mixture of hexane and dichloromethane as the mobile phase. 7.5 g of 4-amino-3-methylbenzonitrile in beige powder form was finally obtained in 93% yield. The 1H-NMR (DMSO-d6) data of the product were as follows: δ 2.27 (3H, s), 6.06 (2H, s), 6.41 (1H, d), 6.46 (1H, s), 7.30 (1H, d).
References
[1] Journal of Medicinal Chemistry, 1999, vol. 42, # 18, p. 3572 - 3587
[2] Patent: US2017/44373, 2017, A1. Location in patent: Paragraph 0227; 0228
[3] Patent: US6353006, 2002, B1. Location in patent: Page column 23
[4] Patent: US2005/54655, 2005, A1. Location in patent: Page/Page column 15
[5] Patent: US2004/44203, 2004, A1. Location in patent: Page 27
4-Amino-3-methylbenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
4-Amino-3-methylbenzonitrile Suppliers
- Tel
- --
- Fax
- --
- sales@tcieurope.be
- Country
- Belgium
- ProdList
- 2200
- Advantage
- 66
View Lastest Price from 4-Amino-3-methylbenzonitrile manufacturers
- Product
- 4-Amino-3-methylbenzonitrile 78881-21-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-04
- Product
- 4-Amino-3-methylbenzonitrile 78881-21-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 4-Amino-3-methylbenzonitrile 78881-21-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12