2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE
- Product Name
- 2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE
- CAS No.
- 934266-82-7
- Chemical Name
- 2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE
- Synonyms
- 2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE;Thiazolo[5,4-b]pyridin-2-amine, 5-bromo-;5-BroMo-thiazolo[5,4-b]pyridin-2-ylaMine;5-broMo-[1,3]thiazolo[5,4-b]pyridin-2-aMine;5-Bromo [1,3]thiazolo[5,4-b]pyridine-2-amine
- CBNumber
- CB61486630
- Molecular Formula
- C6H4BrN3S
- Formula Weight
- 230.09
- MOL File
- 934266-82-7.mol
2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE Property
- Boiling point:
- 382.6±45.0 °C(Predicted)
- Density
- 1.950±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light, stored under nitrogen
- pka
- 0.74±0.40(Predicted)
- Appearance
- Light green to green Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- B704458
- Product name
- 5-Bromothiazolo[5,4-b]pyridin-2-amine
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 7H70-9-54
- Product name
- 5-Bromo-[1,3]thiazolo[5,4-b]pyridin-2-amine
- Packaging
- 1g
- Price
- $314
- Updated
- 2021/12/16
- Product number
- HCH0044860
- Product name
- 5-BROMOTHIAZOLO[5,4-B]PYRIDIN-2-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.16
- Updated
- 2021/12/16
- Product number
- 087227
- Product name
- 5-Bromo-[1,3]thiazolo[5,4-b]pyridin-2-amine
- Purity
- 97%
- Packaging
- 500mg
- Price
- $647
- Updated
- 2021/12/16
- Product number
- FB144225
- Product name
- 5-Bromothiazolo[5,4-b]pyridin-2-amine
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE Chemical Properties,Usage,Production
Synthesis
13534-97-9
333-20-0
934266-82-7
Step A: 6-Bromopyridin-3-amine (1A, 20 g, 1.0 eq.) was added batchwise to a solution of potassium thiocyanate (5.0 eq.) in acetic acid (0.4 M) at -5 °C. The reaction mixture was cooled to -15 °C and a solution of bromine (Br2, 1.3 eq.) in acetic acid (9.4 M) was slowly added dropwise through a constant pressure dropping funnel. After the dropwise addition, the reaction system was slowly warmed to room temperature and stirred continuously for 12 hours. Upon completion of the reaction, the precipitate was collected by filtration. To the filtrate, 100 mL of ethyl acetate (EtOAc) and 200 mL of water (H2O) were added, followed by concentration under reduced pressure to remove 200 mL of solvent by rotary evaporator. The residue was placed in an ice bath with stirring for 10 min, precipitated as a solid, filtered, and washed twice with a cold 10% methanol (MeOH) solution in ether (Et2O). The filtrates were combined and concentrated, and the product was crystallized in an ice bath and washed again twice with cold 10% ether solution of methanol to give a second batch of product. After vacuum drying, the brown solid product 1B was obtained in 77% yield. The product could be used for subsequent reactions without further purification. The product was characterized as follows: 1H NMR (400 MHz, DMSO-d6) δ ppm 4.94 (br.s, 1H), 7.44 (d, J = 8.34 Hz, 1H), 7.57 (d, J = 8.34 Hz, 1H), 8.04 (br.s., 1H); ESI-MS: m/z 230.0 (M + H)+.
References
[1] Patent: US2009/318425, 2009, A1. Location in patent: Page/Page column 39-40
[2] Patent: US2017/291910, 2017, A1. Location in patent: Paragraph 0253; 0254
[3] Patent: WO2010/8847, 2010, A2. Location in patent: Page/Page column 123
[4] Yakugaku Zasshi, 1951, vol. 71, p. 662,665
[5] Chem.Abstr., 1952, p. 8109
2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE manufacturers
- Product
- 2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE 934266-82-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-18