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2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE

Product Name
2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE
CAS No.
934266-82-7
Chemical Name
2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE
Synonyms
2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE;Thiazolo[5,4-b]pyridin-2-amine, 5-bromo-;5-BroMo-thiazolo[5,4-b]pyridin-2-ylaMine;5-broMo-[1,3]thiazolo[5,4-b]pyridin-2-aMine;5-Bromo [1,3]thiazolo[5,4-b]pyridine-2-amine
CBNumber
CB61486630
Molecular Formula
C6H4BrN3S
Formula Weight
230.09
MOL File
934266-82-7.mol
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2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE Property

Boiling point:
382.6±45.0 °C(Predicted)
Density 
1.950±0.06 g/cm3(Predicted)
storage temp. 
2-8°C, protect from light, stored under nitrogen
pka
0.74±0.40(Predicted)
Appearance
Light green to green Solid
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
B704458
Product name
5-Bromothiazolo[5,4-b]pyridin-2-amine
Packaging
500mg
Price
$265
Updated
2021/12/16
SynQuest Laboratories
Product number
7H70-9-54
Product name
5-Bromo-[1,3]thiazolo[5,4-b]pyridin-2-amine
Packaging
1g
Price
$314
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0044860
Product name
5-BROMOTHIAZOLO[5,4-B]PYRIDIN-2-AMINE
Purity
95.00%
Packaging
5MG
Price
$500.16
Updated
2021/12/16
Matrix Scientific
Product number
087227
Product name
5-Bromo-[1,3]thiazolo[5,4-b]pyridin-2-amine
Purity
97%
Packaging
500mg
Price
$647
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144225
Product name
5-Bromothiazolo[5,4-b]pyridin-2-amine
Packaging
50mg
Price
$65
Updated
2021/12/16
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2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE Chemical Properties,Usage,Production

Synthesis

13534-97-9

333-20-0

934266-82-7

Step A: 6-Bromopyridin-3-amine (1A, 20 g, 1.0 eq.) was added batchwise to a solution of potassium thiocyanate (5.0 eq.) in acetic acid (0.4 M) at -5 °C. The reaction mixture was cooled to -15 °C and a solution of bromine (Br2, 1.3 eq.) in acetic acid (9.4 M) was slowly added dropwise through a constant pressure dropping funnel. After the dropwise addition, the reaction system was slowly warmed to room temperature and stirred continuously for 12 hours. Upon completion of the reaction, the precipitate was collected by filtration. To the filtrate, 100 mL of ethyl acetate (EtOAc) and 200 mL of water (H2O) were added, followed by concentration under reduced pressure to remove 200 mL of solvent by rotary evaporator. The residue was placed in an ice bath with stirring for 10 min, precipitated as a solid, filtered, and washed twice with a cold 10% methanol (MeOH) solution in ether (Et2O). The filtrates were combined and concentrated, and the product was crystallized in an ice bath and washed again twice with cold 10% ether solution of methanol to give a second batch of product. After vacuum drying, the brown solid product 1B was obtained in 77% yield. The product could be used for subsequent reactions without further purification. The product was characterized as follows: 1H NMR (400 MHz, DMSO-d6) δ ppm 4.94 (br.s, 1H), 7.44 (d, J = 8.34 Hz, 1H), 7.57 (d, J = 8.34 Hz, 1H), 8.04 (br.s., 1H); ESI-MS: m/z 230.0 (M + H)+.

References

[1] Patent: US2009/318425, 2009, A1. Location in patent: Page/Page column 39-40
[2] Patent: US2017/291910, 2017, A1. Location in patent: Paragraph 0253; 0254
[3] Patent: WO2010/8847, 2010, A2. Location in patent: Page/Page column 123
[4] Yakugaku Zasshi, 1951, vol. 71, p. 662,665
[5] Chem.Abstr., 1952, p. 8109

2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE Suppliers

China 64 India 2 United Kingdom 2 United States 3 Global 71
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE manufacturers

Career Henan Chemical Co
Product
2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE 934266-82-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-12-18

934266-82-7, 2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINERelated Search:


  • 2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE
  • 5-broMo-[1,3]thiazolo[5,4-b]pyridin-2-aMine
  • 5-BroMo-thiazolo[5,4-b]pyridin-2-ylaMine
  • Thiazolo[5,4-b]pyridin-2-amine, 5-bromo-
  • 5-Bromo [1,3]thiazolo[5,4-b]pyridine-2-amine
  • 934266-82-7