IEM 1460 Property

storage temp. 

Desiccate at RT

solubility 

Soluble to 100 mM in water and to 100 mM in DMSO

form 

solid

color 

white

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

IEM 1460 Chemical Properties,Usage,Production

Description

IEM 1460 is an adamantine derivative that blocks both AMPA- and NMDA-type glutamate receptor (GluR) channels (IC₅₀ = 10 μM-0.1 mM). It is selective for Ca²⁺-permeable GluR channels, which lack the GluR2 R subunit, and has been used to identify Ca²⁺-permeable glutamate receptors in the brain.

Uses

IEM 1460 is an Adamantane derivative and open-channel blocker of AMPA currents.

Biological Activity

Voltage-dependent open-channel blocker of AMPA receptors. Displays selectivity between subtypes, blocking GluR2 subunit-lacking (Ca 2+ -permeable) receptors more potently than GluR2-containing receptors (IC 50 values are 2.6 and 1102 μ M respectively). Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo .

storage

Room temperature (desiccate)