ChemicalBook > CAS DataBase List > 4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID

4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID

Product Name
4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID
CAS No.
19156-54-8
Chemical Name
4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID
Synonyms
4,5,6,7-Tetrahy;4,5,6,7-Tetrahydrobenzothiophene-3-carboxylic acid;4,5,6,7-Tetrahydro-ben[B]thiophene-3-carboxylic acid;Benzo[b]thiophene-3-carboxylic acid, 4,5,6,7-tetrahydro-;4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid 97%;2-broMo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid;4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid(SALTDATA: FREE);4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID ISO 9001：2015 REACH
CBNumber
CB61492125
Molecular Formula
C9H10O2S
Formula Weight
182.24
MOL File
19156-54-8.mol
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4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID Property

Melting point:
179-184°C
Boiling point:
350.5±42.0 °C(Predicted)
Density 
1.317±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
4.35±0.20(Predicted)
form 
solid
Appearance
White to off-white Solid
InChI
InChI=1S/C9H10O2S/c10-9(11)7-5-12-8-4-2-1-3-6(7)8/h5H,1-4H2,(H,10,11)
InChIKey
TUZZQEHPGHKGRJ-UHFFFAOYSA-N
SMILES
C12CCCCC=1C(C(O)=O)=CS2
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Safety

WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
760188
Product name
4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid
Purity
97%
Packaging
1g
Price
$153
Updated
2023/06/20
TRC
Product number
T292943
Product name
4,5,6,7-Tetrahydro-1-benzothiophene-3-carboxylicAcid
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
V4044
Product name
4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylicacid
Packaging
1g
Price
$74
Updated
2021/12/16
Apolloscientific
Product number
OR960181
Product name
4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylicacid
Purity
97%
Packaging
1g
Price
$95
Updated
2021/12/16
ChemScene
Product number
CS-0060794
Product name
4,5,6,7-Tetrahydro-1-benzothiophene-3-carboxylicacid
Purity
≥97.0%
Packaging
1g
Price
$50
Updated
2021/12/16
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4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

14559-12-7

19156-54-8

The general procedure for the synthesis of 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid from ethyl 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate was as follows: general method: potassium hydroxide (KOH, 1.7 g, 30 mmol) was added to ethyl 4,5,6,7-tetrahydrobenzo[B]thiophene-3-carboxylate (30 mmol) in aqueous (H2O. 20 mL) emulsion. The mixture was heated under vigorous stirring until a clarified solution was obtained (about 1 h), then stirring was continued for 30 min. The reaction solution was cooled to room temperature and washed with toluene (PhMe); the aqueous layer was separated and acidified with hydrochloric acid (HCl) to pH 4. The precipitate was collected by filtration and recrystallized with a solvent mixture of ethanol (EtOH)-N,N-dimethylformamide (DMF).

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 12, p. 2446 - 2455
[2] Chemistry of Heterocyclic Compounds, 2015, vol. 50, # 12, p. 1748 - 1755
[3] Khim. Geterotsikl. Soedin., 2014, vol. 50, # 12, p. 1900 - 1907,8

4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID Suppliers

China 38 India 2 Ukraine 2 United States 5 Global 47
A.J Chemicals
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
CHEMSWORTH
Tel
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Email
info@chemsworth.com
Country
India
ProdList
6700
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30
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View Lastest Price from 4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co
Product
4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID 19156-54-8
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/T
Release date
2019-12-24

19156-54-8, 4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACIDRelated Search:

2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER ETHYL 2-ACETAMIDO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE ETHYL 2-[(2-CHLOROACETYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXYLATE AKOS 89941 BUTTPARK 123\48-20 ETHYL 2-((3-(2-CHLOROPHENYL)-5-METHYLISOXAZOL-4-YL)CARBONYLAMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE ETHYL 2-(((4-CHLOROPHENYL)AMINO)CARBONYLAMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE ETHYL 2-((THIOXO((4-(TRIFLUOROMETHOXY)PHENYL)AMINO)METHYL)AMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE AURORA 3766 ETHYL 2-(((4-(TRIFLUOROMETHOXY)PHENYL)AMINO)CARBONYLAMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE ETHYL 2-[2-(2,4-DICHLOROPHENOXY)ACETAMIDO]-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE AKOS 93369 ETHYL 2-(((1,3-DIOXOINDAN-2-YLIDENE)METHYL)AMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE BUTTPARK 128\48-16 AKOS AUF1322 AKOS 92930 ETHYL 2-(2,2,3,3,4,4,4-HEPTAFLUOROBUTANOYLAMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE ETHYL 2-((2,2-DICYANOVINYL)AMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE

  • 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid(SALTDATA: FREE)
  • 4,5,6,7-Tetrahydro-ben[B]thiophene-3-carboxylic acid
  • 2-broMo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
  • 4,5,6,7-Tetrahydrobenzothiophene-3-carboxylic acid
  • 4,5,6,7-Tetrahy
  • Benzo[b]thiophene-3-carboxylic acid, 4,5,6,7-tetrahydro-
  • 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid 97%
  • 4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID ISO 9001：2015 REACH
  • 19156-54-8
  • C9H9O2S