2,4-Dichloro-7-fluoroquinazoline

Product Name: 2,4-Dichloro-7-fluoroquinazoline
CAS No.: 174566-15-5
Chemical Name: 2,4-Dichloro-7-fluoroquinazoline
Synonyms: 2,4-Dichloro-7-fluoroqui;2,4-Dichloro-7-fluoroquizoline;4-dichloro-7-fluoroquinazoline;2,4-Dichloro-7-fluoroquinazolin;7-Fluoro-2,4-dichloroquinazoline;2,4-DICHLORO-7-FLUOROQUINAZOLINE;Quinazoline, 2,4-dichloro-7-fluoro-
CBNumber: CB61502167
Molecular Formula: C8H3Cl2FN2
Formula Weight: 217.03
MOL File: 174566-15-5.mol

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2,4-Dichloro-7-fluoroquinazoline Property

Boiling point:: 277 °C
Density: 1.571
Flash point:: 121 °C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.91±0.30(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C8H3Cl2FN2/c9-7-5-2-1-4(11)3-6(5)12-8(10)13-7/h1-3H
InChIKey: HHGKYNUUYMRIAV-UHFFFAOYSA-N
SMILES: N1=C2C(C=CC(F)=C2)=C(Cl)N=C1Cl

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Safety

HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D580248
Product name: 2,4-dichloro-7-fluoroquinazoline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: PC502107
Product name: 2,4-dichloro-7-fluoroquinazoline
Purity: 95%
Packaging: 1g
Price: $92
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: Z15469
Product name: 2,4-Dichloro-7-fluoroquinazoline
Packaging: 1g
Price: $110
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-7-8K
Product name: 2,4-Dichloro-7-fluoroquinazoline
Purity: 95%
Packaging: 1g
Price: $148
Updated: 2021/12/16

Matrix Scientific

Product number: 057328
Product name: 2,4-Dichloro-7-fluoroquinazoline
Purity: 99%
Packaging: 1g
Price: $334
Updated: 2021/12/16

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2,4-Dichloro-7-fluoroquinazoline Chemical Properties,Usage,Production

Uses

2,4-Dichloro-7-fluoroquinazoline is used in preparation of piperazine derivatives as MAGL inhibitors.

Synthesis

76088-98-7

174566-15-5

General procedure for the synthesis of 2,4-dichloro-7-fluoroquinazoline from 7-fluoroquinazoline-2,4(1H,3H)-dione: 7-fluoroquinazoline-2,4(1H,3H)-dione (5.26 g, 29.2 mmol) was mixed with phosphorus trichloride (85 mL) and stirred for 3 days under reflux conditions. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water. The resulting solid product was collected by filtration and dried under vacuum to afford the title compound 2,4-dichloro-7-fluoroquinazoline (3.82 g) as a yellow solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.32 (m, 1H), 7.63 (d, 1H), 7.49 (t, 1H).

References

[1] Patent: WO2005/49033, 2005, A1. Location in patent: Page/Page column 113
[2] Patent: US5688803, 1997, A
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 17, p. 6028 - 6039
[4] Patent: US2016/90374, 2016, A1. Location in patent: Paragraph 0188; 0189
[5] Chemical and Pharmaceutical Bulletin, 2014, vol. 62, # 8, p. 824 - 829

2,4-Dichloro-7-fluoroquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloro-7-fluoroquinazoline Suppliers

China 122 Germany 2 India 1 United States 12 Global 137

SiChuang NanBu Honesty Technology Co., Ltd.

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View Lastest Price from 2,4-Dichloro-7-fluoroquinazoline manufacturers

Career Henan Chemical Co

Product: 2,4-Dichloro-7-fluoroquinazoline 174566-15-5
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-25

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7-Fluoro-2,4-dichloroquinazoline

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4-dichloro-7-fluoroquinazoline

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2,4-Dichloro-7-fluoroqui

174566-15-5

C8H3Cl2FN2