4-chloro-7-fluoro-quinazoline

Product Name: 4-chloro-7-fluoro-quinazoline
CAS No.: 16499-62-0
Chemical Name: 4-chloro-7-fluoro-quinazoline
Synonyms: 4-CHLORO-7-FLUORO-QUINAZOLINE;Quinazoline, 4-chloro-7-fluoro-
CBNumber: CB8465166
Molecular Formula: C8H4ClFN2
Formula Weight: 182.58
MOL File: 16499-62-0.mol

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4-chloro-7-fluoro-quinazoline Property

Boiling point:: 284.9±20.0 °C(Predicted)
Density: 1.447
refractive index: 1.635
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.35±0.30(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C8H4ClFN2/c9-8-6-2-1-5(10)3-7(6)11-4-12-8/h1-4H
InChIKey: JHBYQJRHJVEKPK-UHFFFAOYSA-N
SMILES: N1=C2C(C=CC(F)=C2)=C(Cl)N=C1

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Safety

HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C368168
Product name: 4-Chloro-7-fluoroquinazoline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 057322
Product name: 4-Chloro-7-fluoroquinazoline
Purity: 95%
Packaging: 250mg
Price: $20
Updated: 2021/12/16

Matrix Scientific

Product number: 057322
Product name: 4-Chloro-7-fluoroquinazoline
Purity: 95%
Packaging: 1g
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC905039
Product name: 4-Chloro-7-fluoroquinazoline
Purity: 95%
Packaging: 5g
Price: $245
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-7-A3
Product name: 4-Chloro-7-fluoroquinazoline
Purity: 95%
Packaging: 5G
Price: $392
Updated: 2021/12/16

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4-chloro-7-fluoro-quinazoline Chemical Properties,Usage,Production

Description

4-chloro-7-fluoro-quinazoline is a white crystalline solid. It can be dissolved in organic solvents such as ethanol and dimethylformamide.

Synthesis

16499-57-3

16499-62-0

General procedure for the synthesis of 4-chloro-7-fluoroquinazoline from 7-fluoro-4-quinazolinone: 7-fluoro-3H-quinazolin-4-one (8.2 g, 50 mmol) was mixed with thionyl chloride (80 mL) and the reaction was heated to reflux. After completion of the reaction, the excess thionyl chloride was removed by concentration under reduced pressure to give the target product 4-chloro-7-fluoroquinazoline (9.1 g, quantitative yield).

References

[1] Patent: US2008/70935, 2008, A1. Location in patent: Page/Page column 54
[2] Synthetic Communications, 2011, vol. 41, # 24, p. 3644 - 3653
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 267 - 276
[4] Organic Letters, 2010, vol. 12, # 3, p. 552 - 555
[5] MedChemComm, 2014, vol. 5, # 9, p. 1290 - 1296

4-chloro-7-fluoro-quinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-chloro-7-fluoro-quinazoline Suppliers

China 119 Germany 1 India 2 Ukraine 2 United Kingdom 3 United States 15 Global 142

Nanjing Pope Bio-tech R&D Co., Ltd

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View Lastest Price from 4-chloro-7-fluoro-quinazoline manufacturers

Career Henan Chemical Co

Product: 4-CHLORO-7-FLUORO-QUINAZOLINE 16499-62-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500KG
Release date: 2018-08-19

16499-62-0, 4-chloro-7-fluoro-quinazolineRelated Search:

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4-CHLORO-7-FLUORO-QUINAZOLINE

Quinazoline, 4-chloro-7-fluoro-

16499-62-0

pharmacetical

Halides

CHIRAL CHEMICALS

Fused Ring Systems