ChemicalBook > CAS DataBase List >  4-chloro-7-fluoro-quinazoline

4-chloro-7-fluoro-quinazoline

Product Name
4-chloro-7-fluoro-quinazoline
CAS No.
16499-62-0
Chemical Name
4-chloro-7-fluoro-quinazoline
Synonyms
4-CHLORO-7-FLUORO-QUINAZOLINE;Quinazoline, 4-chloro-7-fluoro-
CBNumber
CB8465166
Molecular Formula
C8H4ClFN2
Formula Weight
182.58
MOL File
16499-62-0.mol
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4-chloro-7-fluoro-quinazoline Property

Boiling point:
284.9±20.0 °C(Predicted)
Density 
1.447
refractive index 
1.635
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
0.35±0.30(Predicted)
Appearance
White to yellow Solid
InChI
InChI=1S/C8H4ClFN2/c9-8-6-2-1-5(10)3-7(6)11-4-12-8/h1-4H
InChIKey
JHBYQJRHJVEKPK-UHFFFAOYSA-N
SMILES
N1=C2C(C=CC(F)=C2)=C(Cl)N=C1
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Safety

HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C368168
Product name
4-Chloro-7-fluoroquinazoline
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
057322
Product name
4-Chloro-7-fluoroquinazoline
Purity
95%
Packaging
250mg
Price
$20
Updated
2021/12/16
Matrix Scientific
Product number
057322
Product name
4-Chloro-7-fluoroquinazoline
Purity
95%
Packaging
1g
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC905039
Product name
4-Chloro-7-fluoroquinazoline
Purity
95%
Packaging
5g
Price
$245
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-7-A3
Product name
4-Chloro-7-fluoroquinazoline
Purity
95%
Packaging
5G
Price
$392
Updated
2021/12/16
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4-chloro-7-fluoro-quinazoline Chemical Properties,Usage,Production

Description

4-chloro-7-fluoro-quinazoline is a white crystalline solid. It can be dissolved in organic solvents such as ethanol and dimethylformamide.

Synthesis

16499-57-3

16499-62-0

General procedure for the synthesis of 4-chloro-7-fluoroquinazoline from 7-fluoro-4-quinazolinone: 7-fluoro-3H-quinazolin-4-one (8.2 g, 50 mmol) was mixed with thionyl chloride (80 mL) and the reaction was heated to reflux. After completion of the reaction, the excess thionyl chloride was removed by concentration under reduced pressure to give the target product 4-chloro-7-fluoroquinazoline (9.1 g, quantitative yield).

References

[1] Patent: US2008/70935, 2008, A1. Location in patent: Page/Page column 54
[2] Synthetic Communications, 2011, vol. 41, # 24, p. 3644 - 3653
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 267 - 276
[4] Organic Letters, 2010, vol. 12, # 3, p. 552 - 555
[5] MedChemComm, 2014, vol. 5, # 9, p. 1290 - 1296

4-chloro-7-fluoro-quinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-chloro-7-fluoro-quinazoline manufacturers

Career Henan Chemical Co
Product
4-CHLORO-7-FLUORO-QUINAZOLINE 16499-62-0
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500KG
Release date
2018-08-19

16499-62-0, 4-chloro-7-fluoro-quinazolineRelated Search:

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  • 4-CHLORO-7-FLUORO-QUINAZOLINE
  • Quinazoline, 4-chloro-7-fluoro-
  • 16499-62-0
  • pharmacetical
  • Halides
  • CHIRAL CHEMICALS
  • Fused Ring Systems