1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE

Product Name: 1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE
CAS No.: 18048-64-1
Chemical Name: 1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE
Synonyms: 2-(3,4-dimethylphenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one;Eltrombopag int2;Eltrombopag Impurity 66;2-Pyrazolin-5-one, 3-Methyl-1-(3,4-xylyl)-;2-(3,4-dimethylphenyl)-5-methyl-4H-pyrazol-3-one;3-Methyl-1-(3,4-dimethylphenyl)-2-pyrazolin-5-one;1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE;1-(3,4-diMethylphenyl)-3-Methyl-3-pyrazolin-5-tone;1-(3,4-diMethylphenyl)-3-Methyl-1H-pyrazol-5(4H)-one;3-Methyl-1-(3,4-dimethylphenyl)-1H-pyrazol-5(4H)-one
CBNumber: CB61502369
Molecular Formula: C12H14N2O
Formula Weight: 202.25
MOL File: 18048-64-1.mol

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1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE Property

Melting point:: 116-119℃
Boiling point:: 390.1±31.0 °C(Predicted)
Density: 1.13
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly)
pka: 2.77±0.50(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C12H14N2O/c1-8-4-5-11(6-9(8)2)14-12(15)7-10(3)13-14/h4-6H,7H2,1-3H3
InChIKey: GJBBAPXESBCGRU-UHFFFAOYSA-N
SMILES: N1=C(C)CC(=O)N1C1=CC=C(C)C(C)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D948598
Product name: 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one
Packaging: 5mg
Price: $135
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1016086
Product name: 1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE
Purity: 95.00%
Packaging: 5MG
Price: $498.3
Updated: 2021/12/16

AK Scientific

Product number: X3181
Product name: 1-(3,4-Dimethylphenyl)-3-methyl-3-pyrazolin-5-one
Packaging: 25g
Price: $860
Updated: 2021/12/16

Chemenu

Product number: CM188235
Product name: 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one
Purity: 95+%
Packaging: 25g
Price: $1169
Updated: 2021/12/16

Chemenu

Product number: CM188235
Product name: 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one
Purity: 95+%
Packaging: 10g
Price: $506
Updated: 2021/12/16

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1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE Chemical Properties,Usage,Production

Uses

1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one is a reagent used in the enantioselective aminoalkylation of pyrazol-3-ones.

Synthesis

141-97-9

60481-51-8

18048-64-1

3,4-Dimethylphenylhydrazine hydrochloride (8.7 g, 50 mmol) was dissolved in 100 mL of glacial acetic acid and ethyl acetoacetate (6.5 g, 50 mmol) and sodium acetate (4.1 g, 50 mmol) were added. The reaction mixture was heated to 120°C and refluxed for 7 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC) until the feedstock was fully reacted. After completion of the reaction, ethyl acetate was removed by evaporation under reduced pressure. 100 mL of water was added to the residue and extracted four times with 100 mL of ethyl acetate. The ethyl acetate layers were combined and concentrated directly under reduced pressure without drying with anhydrous sodium sulfate to afford 1-(3,4-dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one (8.3 g, 82% yield).

References

[1] Patent: CN103360317, 2016, B. Location in patent: Paragraph 0095; 0105; 0106; 0108

1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE Suppliers

China 134 India 8 United Kingdom 1 United States 3 Global 146

Anhui Sun-wise Pharmaceutical Co., Ltd.

Tel: 18856027890 18856027890
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Nanjing Vcare PharmaTech Co., Ltd

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Energy Chemical

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SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

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Acesys Pharmatech

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Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
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View Lastest Price from 1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE manufacturers

Guangzhou Tosun Pharmaceutical Ltd

Product: Eltrombopag Impurity 66
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 95%+
Supply Ability: 1000mg
Release date: 2025-02-13

Henan Aochuang Chemical Co.,Ltd.

Product: 1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE 18048-64-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE 18048-64-1
Price: US $95.00-950.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-06

18048-64-1, 1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONERelated Search:

3-Methyl-3-pyrazolin-5-one TOSLAB 135139 TOSLAB 135183 TOSLAB 135111 TOSLAB 135122 Eltrombopag 1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE TOSLAB 135097 TOSLAB 135087

1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE

3-Methyl-1-(3,4-dimethylphenyl)-2-pyrazolin-5-one

3H-Pyrazol-3-one,2-(3,4-diMethylphenyl)-2,4-dihydro-5-Methyl-

1-(3,4-diMethylphenyl)-3-Methyl-1H-pyrazol-5(4H)-one

2-(3,4-dimethylphenyl)-5-methyl-4H-pyrazol-3-one

2-(3,4-Dimethylphenyl)-2,4-dihydro-5-methyl-3H-pyrazol-3-one

1-(3,4-diMethylphenyl)-3-Methyl-3-pyrazolin-5-tone

2-Pyrazolin-5-one, 3-Methyl-1-(3,4-xylyl)-

2-(3,4-dimethylphenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one

1-(3,4-dimethylphenyl)-3-methyl-4,5-dihydro-1H-pyrazol-5-one

Eltrombopag int2

1-(3,4-DIMETHYLPHENYL)-3-METHYL-3-PYRAZOLIN-5-ONE ISO 9001：2015 REACH

1- (3,4-dimethylphenyl) - 3-methyl-1h-pyrazole-5 (4h) one

Eltrombopag Impurity 66

2-(3,4-Dimethylphenyl)-5-methyl-2,4-dihydropyrazol-3-one

1-(3,4-dimethylphenyl)-3-methyl-1H-pyrazolin-5(4H)-one

3-Methyl-1-(3,4-dimethylphenyl)-1H-pyrazol-5(4H)-one

3-methyl-1-(3,4-dimethylphenyl)-2-pyridineazoleline-5-one

18048-64-1